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GW 583340 dihydrochloride - ≥97%(HPLC), high purity , CAS No.1173023-85-2
Potent dual EGFR/ErbB2 inhibitor; orally active
Basic Description Specifications & Purity Moligand™, ≥97%(HPLC) Biochemical and Physiological Mechanisms Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50values are 0.01 and 0.014μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50values are 0.11μM for inhibition of HN5, N87 and BT474 tumor cell lines vs Storage Temp Store at 2-8°C,Desiccated Shipped In Wet ice Grade Moligand™
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-1,3-thiazol-4-yl]quinazolin-4-amine;dihydrochloride INCHI InChI=1S/C28H25ClFN5O3S2.2ClH/c1-40(36,37)10-9-31-14-27-35-25(16-39-27)19-5-7-24-22(12-19)28(33-17-32-24)34-21-6-8-26(23(29)13-21)38-15-18-3-2-4-20(30)11-18;;/h2-8,11-13,16-17,31H,9-10,14-15H2,1H3,(H,32,33,34);2*1H InChi Key WIMITXDBYLKRKB-UHFFFAOYSA-N Canonical SMILES CS(=O)(=O)CCNCC1=NC(=CS1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.Cl.Cl Isomeric SMILES CS(=O)(=O)CCNCC1=NC(=CS1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.Cl.Cl PubChem CID 16219404 MeSH Entry Terms GW 583340;GW-583340;GW583340 Molecular Weight 671.03
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 67.1, Max Conc. mM: 100 with gentle warming
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