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Home Metabolism Types of disease Obesity GW 590735 - ≥98%, high purity , Peroxisome proliferator-activated receptor alpha agonist, CAS No.622402-22-6, Peroxisome proliferator-activated receptor alpha agonist
GW 590735 - ≥98%, high purity , Peroxisome proliferator-activated receptor alpha agonist, CAS No.622402-22-6, Peroxisome proliferator-activated receptor alpha agonist
Potent, selective PPARα agonist
Basic Description Synonyms GW 590735 | 622402-22-6 | 343321-96-0 | GW590735 | GW-590735 | 2-methyl-2-(4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)methyl)phenoxy)propanoic acid | QKY617BBX5 | CHEMBL219586 | 2-Methyl-2-(4-{[({4-Methyl-2-[4-(Trifluoromethyl)phenyl]-1,3-Thiazol-5- Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Potent, selective PPARα agonist (EC 50 = 4 nM). Increases HDL cholesterol, decreases LDL and VLDL cholesterol. Reduces triglycerides. Shows antidyslipidemic effects in vivo. Storage Temp Protected from light,Store at -20°C,Desiccated Shipped In Ice chest + Ice pads Action Type AGONIST Mechanism of action Peroxisome proliferator-activated receptor alpha agonist Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 2-methyl-2-[4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbonyl]amino]methyl]phenoxy]propanoic acid INCHI InChI=1S/C23H21F3N2O4S/c1-13-18(33-20(28-13)15-6-8-16(9-7-15)23(24,25)26)19(29)27-12-14-4-10-17(11-5-14)32-22(2,3)21(30)31/h4-11H,12H2,1-3H3,(H,27,29)(H,30,31) InChi Key ILUPZUOBHCUBKB-UHFFFAOYSA-N Canonical SMILES CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NCC3=CC=C(C=C3)OC(C)(C)C(=O)O Isomeric SMILES CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NCC3=CC=C(C=C3)OC(C)(C)C(=O)O Alternate CAS 343321-96-0 PubChem CID 9956726 Molecular Weight 478.48
Chemical and Physical Properties Solubility Soluble in ethanol to 50 mM and in DMSO to 50 mM Sensitivity Light sensitive
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