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GW 627368 - ≥98%(HPLC), high purity , CAS No.439288-66-1, Antagonist of EP 4 receptor

Moligand™
≥98%(HPLC)

CAS#: 439288-66-1
Formula: C₃₀H₂₈N₂O₆S
Molecular Weight: 544.62
PubChem CID: 5312130

Item Number

G288949

Grouped product items
SKU	Size	Availability	Price
G288949-1mg	1mg	In stock	$15.90
G288949-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$64.90
G288949-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$97.90
G288949-25mg	25mg	In stock	$162.90
G288949-50mg	50mg	In stock	$271.90
G288949-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,224.90

Selective EP4receptor competitive antagonist

View related series

EP4 receptor Antagonist

Basic Description

Synonyms	439288-66-1\|GW627368\|GW 627368\|GW 627368X\|GW-627368X\|GW627368X\|2-(4-(4,9-Diethoxy-1-oxo-1H-benzo[f]isoindol-2(3H)-yl)phenyl)-N-(phenylsulfonyl)acetamide\|GW-627368\|N-(benzenesulfonyl)-2-[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)phenyl]acetamide\|A9P1Z
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective prostanoid EP4receptor competitive antagonist with additional affinity at TP receptors (pKivalues are 7.0 and 6.8 in competition radioligand bioassays). Affinity for all other prostanoid receptors is < 5.3. Inhibits U-46619 induced human platel
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of EP 4 receptor

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGER4 Tclin Prostaglandin E2 receptor EP4 subtype 0 Activities

Discover Target: PTGER4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-(benzenesulfonyl)-2-[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)phenyl]acetamide
INCHI	InChI=1S/C30H28N2O6S/c1-3-37-28-23-12-8-9-13-24(23)29(38-4-2)27-25(28)19-32(30(27)34)21-16-14-20(15-17-21)18-26(33)31-39(35,36)22-10-6-5-7-11-22/h5-17H,3-4,18-19H2,1-2H3,(H,31,33)
InChi Key	XREWXJVMYAXCJV-UHFFFAOYSA-N
Canonical SMILES	CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=CC=C(C=C4)CC(=O)NS(=O)(=O)C5=CC=CC=C5
Isomeric SMILES	CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=CC=C(C=C4)CC(=O)NS(=O)(=O)C5=CC=CC=C5
PubChem CID	5312130
Molecular Weight	544.62

PubChem CID

ChEMBL Ligand

CAS Registry No.

GPCRdb Ligand

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6 results found

Lot Number	Certificate Type	Date	Item
J2115201	Certificate of Analysis	Jul 15, 2024	G288949
J2115223	Certificate of Analysis	Jul 15, 2024	G288949
J2115247	Certificate of Analysis	Jul 15, 2024	G288949
J2115314	Certificate of Analysis	Jul 15, 2024	G288949
J2115348	Certificate of Analysis	Jul 15, 2024	G288949
J2115351	Certificate of Analysis	Jul 15, 2024	G288949

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