GW2580 - ≥99%, high purity , CAS No.870483-87-7, Inhibitor of colony stimulating factor 1 receptor;Inhibitor of neurotrophic receptor tyrosine kinase 1;Inhibitor of neurotrophic receptor tyrosine kinase 2;Inhibitor of neurotrophic receptor tyrosine kinase 3

Item Number

G129822

• Synonyms: GW-2580 | 5-({3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl}methyl)pyrimidine-2,4-diamine | EN300-08618 | SCHEMBL4326587 | MLS000758242 | Q27077940 | 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine | 5-[3-Methoxy-4-(4-methoxybenzyloxy)-
• Specifications & Purity: Moligand™, ≥99%
• Biochemical and Physiological Mechanisms: Selective cFMS (colony stimulating factor 1) RTK inhibitor. Inhibits monocyte growth in vitro (IC 50 = 0.2 μM) and LPS-induced TNF-α production in vivo . Inhibits macrophage infiltration of the CNS. Orally active. Cell-permeable.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of colony stimulating factor 1 receptor;Inhibitor of neurotrophic receptor tyrosine kinase 1;Inhibitor of neurotrophic receptor tyrosine kinase 2;Inhibitor of neurotrophic receptor tyrosine kinase 3
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

GW2580 is an orally bioavailable and selective inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 μM. GW2580 acts as a competitive inhibitor of ATP binding to the cFMS kinase and inhibits colony-stimulating-factor-1 signaling