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GW4064 - ≥98%, high purity , CAS No.278779-30-9, Agonist of Farnesoid X receptor
Selective farnesoid X receptor (FXR) agonist
Basic Description Synonyms 278779-30-9|GW 4064|GW4064|GW-4064|(E)-3-(2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)styryl)benzoic acid|1089660-72-9|GW-4064X|SR225WUZ0H|CHEMBL318457|CHEBI:79997|Benzoic acid, 3-(2-(2-chloro-4-((3-(2,6-dichlorophenyl)-5-(1-methy Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms Selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50= 15 nM). Displays no activity at other nuclear receptors at concentrations up to 1μM. Improves hyperglycaemia and hyperlipidemia in diabetic db/db mice. Shown to suppress autophagy in nutri Storage Temp Store at 2-8°C Shipped In Wet ice Grade Moligand™ Action Type AGONIST Mechanism of action Agonist of Farnesoid X receptor Product Description
GW4064 is an agonist of farnesoid X receptor (FXR) with EC50 of 65 nM in CV1 cell line and displays no activity at other nuclear receptors at concentrations up to 1 μM.
Names and Identifiers Pubchem Sid 488196405 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488196405 IUPAC Name 3-[(E)-2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]methoxy]phenyl]ethenyl]benzoic acid INCHI InChI=1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)15-35-20-12-11-18(24(31)14-20)10-9-17-5-3-6-19(13-17)28(33)34/h3-14,16H,15H2,1-2H3,(H,33,34)/b10-9+ InChi Key BYTNEISLBIENSA-MDZDMXLPSA-N Canonical SMILES CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC(=C(C=C3)C=CC4=CC(=CC=C4)C(=O)O)Cl Isomeric SMILES CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC(=C(C=C3)/C=C/C4=CC(=CC=C4)C(=O)O)Cl WGK Germany 3 Alternate CAS 292047-56-4,1089660-72-9,278779-30-9 PubChem CID 9893571 MeSH Entry Terms GW 4064;GW-4064;GW4064 Molecular Weight 542.84
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 54.3, Max Conc. mM: 100
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H319: Causes serious eye irritation
H413: May cause long lasting harmful effects to aquatic life
H302: Harmful if swallowed
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P337+P317: If eye irritation persists: Get medical help.
WGK Germany 3
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