The store will not work correctly when cookies are disabled.
GW501516 - 10mM in DMSO, high purity , CAS No.317318-70-0
1 Citations
Potent and selective PPARδ agonist
Basic Description
| Synonyms | 317318-70-0 | Endurobol | GW501516 | GW 501516 | GW-501516 | Cardarine | GSK-516 | GW1516 | GW 1516 | UNII-7I2HA1NU22 | GW-1516 | 2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic acid | 2-(2-Methyl-4-(((4-methyl-2-(4-(trifluoromethyl)p |
|---|
| Specifications & Purity | Moligand™, 10mM in DMSO |
|---|
| Biochemical and Physiological Mechanisms | Potent and selective PPARδagonist (EC50= 1.2 nM). Displays <1000-fold selectivity over other PPAR subtypes. Increases ABC A1 transporter expression and induces apolipoprotein A1-mediated cholesterol effluxin vitro. Also increase serum HDL cholesterol and |
|---|
| Storage Temp | Store at -80°C |
|---|
| Shipped In | Ice chest + Ice pads |
|---|
| Grade | Moligand™ |
|---|
| Product Description | {2-Methyl-4-{{4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl}methylthio}phenoxy}acetic acid |
|---|
Associated Targets(Human)
Associated Targets(non-human)
Names and Identifiers
| IUPAC Name | 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid |
|---|
| INCHI | InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27) |
|---|
| InChi Key | YDBLKRPLXZNVNB-UHFFFAOYSA-N |
|---|
| Canonical SMILES | CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC=C(C=C3)C(F)(F)F)C)OCC(=O)O |
|---|
| Isomeric SMILES | CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC=C(C=C3)C(F)(F)F)C)OCC(=O)O |
|---|
| RTECS | AI9105500 |
|---|
| PubChem CID | 9803963 |
|---|
| Molecular Weight | 453.5 |
|---|
| Beilstein | 18515150 |
|---|
Citations of This Product
| 1. Xian Sun, Yanqing Xie, Xiyang Zhang, Jiebing Song, Yuping Wu. (2023) Estimation of Per- and Polyfluorinated Alkyl Substance Induction Equivalency Factors for Humpback Dolphins by Transactivation Potencies of Peroxisome Proliferator-Activated Receptors. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (9): (3713–3721). [PMID:36812292] |
References
| 1. Xian Sun, Yanqing Xie, Xiyang Zhang, Jiebing Song, Yuping Wu. (2023) Estimation of Per- and Polyfluorinated Alkyl Substance Induction Equivalency Factors for Humpback Dolphins by Transactivation Potencies of Peroxisome Proliferator-Activated Receptors. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (9): (3713–3721). [PMID:36812292] |
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
