GW6471 - 98%, high purity , CAS No.880635-03-0, Antagonist of Peroxisome proliferator-activated receptor-α

Item Number

G341982

Grouped product items
SKU	Size	Availability	Price
G341982-5mg	5mg	In stock	$147.90
G341982-10mg	10mg	In stock	$216.90
G341982-25mg	25mg	In stock	$488.90
G341982-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$870.90
G341982-100mg	100mg	In stock	$1,533.90
G341982-500mg	500mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$6,903.90

a complete inhibitor of PPARα that allows interaction with co-repressors

Basic Description

Synonyms	GTPL3440 \| MLS006010816 \| NCGC00165799-01 \| SCHEMBL15153020 \| N-[(2S)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-[[(Z)-4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl]amino]propyl]propanamide \| Propanamide, N-((2S)-2-(((1Z)-1-methyl-3-ox
Specifications & Purity	≥98%
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Action Type	ANTAGONIST
Mechanism of action	Antagonist of Peroxisome proliferator-activated receptor-α
Product Description	GW6471 is a PPARα antagonist, shown to completely inhibit GW409544-induced activation of PPARα. GW6471 induces a PPARα conformation that interacts efficiently with co-repressors.

Names and Identifiers

Pubchem Sid	488189847
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488189847
IUPAC Name	N-[(2S)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-[[(Z)-4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl]amino]propyl]propanamide
INCHI	InChI=1S/C35H36F3N3O4/c1-4-33(43)39-22-29(40-23(2)20-32(42)26-12-14-28(15-13-26)35(36,37)38)21-25-10-16-30(17-11-25)44-19-18-31-24(3)45-34(41-31)27-8-6-5-7-9-27/h5-17,20,29,40H,4,18-19,21-22H2,1-3H3,(H,39,43)/b23-20-/t29-/m0/s1
InChi Key	TYEFSRMOUXWTDN-DYQICHDWSA-N
Canonical SMILES	CCC(=O)NCC(CC1=CC=C(C=C1)OCCC2=C(OC(=N2)C3=CC=CC=C3)C)NC(=CC(=O)C4=CC=C(C=C4)C(F)(F)F)C
Isomeric SMILES	CCC(=O)NC[C@H](CC1=CC=C(C=C1)OCCC2=C(OC(=N2)C3=CC=CC=C3)C)N/C(=C\C(=O)C4=CC=C(C=C4)C(F)(F)F)/C
WGK Germany	3
Alternate CAS	436159-64-7
PubChem CID	446738
Molecular Weight	619.67

Certificates

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

14 results found

Lot Number	Certificate Type	Date	Item
E2326490	Certificate of Analysis	Jun 02, 2023	G341982
E2326560	Certificate of Analysis	Jun 02, 2023	G341982
E2326563	Certificate of Analysis	Jun 02, 2023	G341982
E2326679	Certificate of Analysis	Jun 02, 2023	G341982
E2326493	Certificate of Analysis	Jun 02, 2023	G341982
E2326495	Certificate of Analysis	Jun 02, 2023	G341982
E2326498	Certificate of Analysis	Jun 02, 2023	G341982
E2326501	Certificate of Analysis	Jun 02, 2023	G341982
E2326559	Certificate of Analysis	Jun 02, 2023	G341982
C2219275	Certificate of Analysis	Jan 27, 2022	G341982
C2219277	Certificate of Analysis	Jan 27, 2022	G341982
C2219301	Certificate of Analysis	Jan 27, 2022	G341982
C2219303	Certificate of Analysis	Jan 27, 2022	G341982
C2219307	Certificate of Analysis	Jan 27, 2022	G341982

Show more⌵

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3

Citations of This Product

1. Yuhang Li, Yitian Li, Sennan Xu, Yue Chen, Pan Zhou, Ting Hu, Hua Li, Ying Liu, Yaping Xu, Jie Ren, Yan Qiu, Canzhong Lu. (2022) N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturation. PHARMACOLOGICAL RESEARCH, 185 (106491). [PMID:36244543] [10.1016/j.phrs.2022.106491]

References

1. Yuhang Li, Yitian Li, Sennan Xu, Yue Chen, Pan Zhou, Ting Hu, Hua Li, Ying Liu, Yaping Xu, Jie Ren, Yan Qiu, Canzhong Lu. (2022) N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturation. PHARMACOLOGICAL RESEARCH, 185 (106491). [PMID:36244543] [10.1016/j.phrs.2022.106491]

Solution Calculators

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.