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GW788388 - ≥98%, high purity , CAS No.452342-67-5
Potent and selective inhibitor of TGF-βRI
Basic Description Synonyms FT-0700309 | HMS3656N21 | UNII-N14114957J | Q27284368 | N-(oxan-4-yl)-4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}benzamide | A6195 | AC-31390 | BCP04559 | BCP9000754 | Benzamide, 4-(4-(3-(2-pyridinyl)-1H-pyrazol-4-yl)-2-pyridinyl)-N-(tetrahydro-2 Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Potent inhibitor of transforming growth factor-βtype I receptor (ALK5) (IC50values are 18 and 93 nM for ALK5 binding and for TGF-βcellular assay respectively). Inhibits esophageal squamous cell carcinoma (ESCC)-induced neoangiogenesis. Reduces renal fibro Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Note 卖完停产，不再备货 Product Description GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N-(oxan-4-yl)-4-[4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridin-2-yl]benzamide INCHI InChI=1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31) InChi Key SAGZIBJAQGBRQA-UHFFFAOYSA-N Canonical SMILES C1COCCC1NC(=O)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C(NN=C4)C5=CC=CC=N5 Isomeric SMILES C1COCCC1NC(=O)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C(NN=C4)C5=CC=CC=N5 PubChem CID 10202642 Molecular Weight 425.48
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 42.55, Max Conc. mM: 100
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