GW791343 - ≥98%, high purity , CAS No.1019779-04-4, Allosteric modulator of P2X7

Item Number

G275203

Grouped product items
SKU	Size	Availability	Price	Qty
G275203-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$141.90
G275203-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$450.90

P2X 7 allosteric modulator

View related series

Basic Description

Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	P2X 7 allosteric modulator. Activity differs with species: acts as a negative allosteric modulator of human P2X 7 (pIC 50 = 6.9 - 7.2) and a positive allosteric modulator of rat P2X 7 receptors that increases the potency and effect of ATP.
Storage Temp	Room temperature,Desiccated
Shipped In	Normal
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of P2X7
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.

Names and Identifiers

IUPAC Name	2-(3,4-difluoroanilino)-N-[2-methyl-5-(piperazin-1-ylmethyl)phenyl]acetamide;dihydrochloride
INCHI	InChI=1S/C20H24F2N4O.2ClH/c1-14-2-3-15(13-26-8-6-23-7-9-26)10-19(14)25-20(27)12-24-16-4-5-17(21)18(22)11-16;;/h2-5,10-11,23-24H,6-9,12-13H2,1H3,(H,25,27);2*1H
InChi Key	IYJPZTBIYHPSKF-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C=C(C=C1)CN2CCNCC2)NC(=O)CNC3=CC(=C(C=C3)F)F.Cl.Cl
Isomeric SMILES	CC1=C(C=C(C=C1)CN2CCNCC2)NC(=O)CNC3=CC(=C(C=C3)F)F.Cl.Cl
PubChem CID	71576670
Molecular Weight	483.81

References

1. Michel AD, Chambers LJ, Walter DS. (2008) Negative and positive allosteric modulators of the P2X(7) receptor.. Br J Pharmacol, 153 (4): (737-50). [PMID:18071294] [10.1021/op500134e]
2. Michel AD, Clay WC, Ng SW, Roman S, Thompson K, Condreay JP, Hall M, Holbrook J, Livermore D, Senger S. (2008) Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects.. Br J Pharmacol, 155 (5): (738-51). [PMID:18660826] [10.1021/op500134e]

Solution Calculators

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.

Basic Description