GW791343 - ≥98%, high purity , CAS No.1019779-04-4, Allosteric modulator of P2X7

Item Number

G275203

Grouped product items
SKU	Size	Availability	Price	Qty
G275203-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$141.90
G275203-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$450.90

P2X 7 allosteric modulator

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Basic Description

Synonyms	2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]acetamidetrihydrochloride
Specifications & Purity	≥98%
Storage Temp	Room temperature,Desiccated
Shipped In	Normal
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of P2X7
Product Description	Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.

Names and Identifiers

IUPAC Name	2-(3,4-difluoroanilino)-N-[2-methyl-5-(piperazin-1-ylmethyl)phenyl]acetamide;dihydrochloride
INCHI	InChI=1S/C20H24F2N4O.2ClH/c1-14-2-3-15(13-26-8-6-23-7-9-26)10-19(14)25-20(27)12-24-16-4-5-17(21)18(22)11-16;;/h2-5,10-11,23-24H,6-9,12-13H2,1H3,(H,25,27);2*1H
InChi Key	IYJPZTBIYHPSKF-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C=C(C=C1)CN2CCNCC2)NC(=O)CNC3=CC(=C(C=C3)F)F.Cl.Cl
Isomeric SMILES	CC1=C(C=C(C=C1)CN2CCNCC2)NC(=O)CNC3=CC(=C(C=C3)F)F.Cl.Cl
PubChem CID	71576670
Molecular Weight	483.81

PubChem CID

ChEMBL Ligand

CAS Registry No.

RCSB PDB Ligand

References

1. Michel AD, Chambers LJ, Walter DS. (2008) Negative and positive allosteric modulators of the P2X(7) receptor.. Br J Pharmacol, 153 (4): (737-50). [PMID:18071294]
2. Michel AD, Clay WC, Ng SW, Roman S, Thompson K, Condreay JP, Hall M, Holbrook J, Livermore D, Senger S. (2008) Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects.. Br J Pharmacol, 155 (5): (738-51). [PMID:18660826]

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Basic Description