GW9662 - 97%, high purity , CAS No.22978-25-2, Antagonist of Peroxisome proliferator-activated receptor-γ

Item Number

G283876

• Synonyms: Benzanilide, 2-chloro-5-nitro- (8CI) | SCHEMBL420231 | Benzamide,2-chloro-5-nitro-N-phenyl- | Bio2_000341 | HMS3267P20 | HMS3676F15 | EC-000.2405 | GTPL3442 | HMS3262O18 | HMS3412F15 | METHYL15-METHYLHEPTADECANOATE | NCGC00025193-04 | NCGC00261483-01 | AC
• Specifications & Purity: Moligand™, ≥97%
• Biochemical and Physiological Mechanisms: GW 9662 is a selective, irreversible, and effective peroxisome proliferator activated receptor-γ (PPARγ) antagonist. PPARγ research demonstrates that GW 9662 covalently modifies Cys(285) and does not affect transcription of full-length PPARα and PPARδ. GW
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: ANTAGONIST
• Mechanism of action: Antagonist of Peroxisome proliferator-activated receptor-γ
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM, with at least 100 to 1000-fold functional selectivity in cells with PPARγ versus PPARα and PPARδ.
A selective, irreversible, and effective PPARγ antagonist that also acts as a FXR and PXR agonist.