Selective non-competitive AMPA receptor antagonist (IC 50 values are 10-20, approx. 450 and >50 μM for AMPA- , kainate- and NMDA-induced responses, respectively).
Storage Temp
Room temperature,Desiccated
Shipped In
Normal
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of GluA1;Antagonist of GluA2;Antagonist of GluA3;Antagonist of GluA4
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
1.Sasaki T et al.. (2012) Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation.. Proc Natl Acad Sci U S A, 109 (50):(20720-5). [PMID:23185019]
2.Srivastava R et al.. (2012) Cocaine-taking and cocaine-seeking behaviors in rats remain stable after systemic administration of GYKI 52466: a non-competitive AMPA receptor antagonist.. Neurosci Lett, 508 (2):(106-9). [PMID:22206835]
3.Hartung H et al.. (2011) Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens.. Neuropsychopharmacology, 36 (9):(1811-22). [PMID:21508928]
4.Threlfell S et al.. (2012) Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons.. Neuron, 75 (58-64). [PMID:22794260]
5.Platt NJ et al.. (2012) Striatal dopamine transmission is subtly modified in human A53Ta-synuclein overexpressing mice.. PLoS One, 7 (5):(e36397). [PMID:22570709]
6.Threlfell S et al.. (2010) Striatal muscarinic receptors promote activity dependence of dopamine transmission via distinct receptor subtypes on cholinergic interneurons in ventral versus dorsal striatum.. J Neurosci, 30 (9):(3398-408). [PMID:20203199]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
