JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

྾

Home
Applications
Targets
Other protein targets
Non-catalytic pattern recognition receptors
H 151 - ≥98%(HPLC), high purity , CAS No.941987-60-6, Antagonist of stimulator of interferon response cGAMP interactor 1

Skip to the end of the images gallery

Skip to the beginning of the images gallery

H 151 - ≥98%(HPLC), high purity , CAS No.941987-60-6, Antagonist of stimulator of interferon response cGAMP interactor 1

1 Citations

Moligand™

≥98%(HPLC)

CAS#: 941987-60-6
Formula: C₁₇H₁₇N₃O
Molecular Weight: 279.34
PubChem CID: 7616033

Item Number

H287635

Grouped product items
SKU	Size	Availability	Price
H287635-5mg	5mg	In stock	$44.90
H287635-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$69.90
H287635-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$279.90
H287635-100mg	100mg	In stock	$429.90
H287635-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$799.90

STING antagonist

View related series

stimulator of interferon response cGAMP interactor 1 Antagonist

Basic Description

Synonyms	1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea \| 3-(4-ethylphenyl)-1-(1H-indol-3-yl)urea \| N-(4-ethylphenyl)-N'-1H-indol-3-yl-urea \| H-151
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	H-151 is an irreversible antagonist of the stimulator of interferon genes (STING) protein, a central signalling component of the cytosolic DNA sensing pathway. Although STING is a vital component of the innate immune pathways, it has also been shown to ha
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of stimulator of interferon response cGAMP interactor 1

Associated Targets(Human)

TMEM173 Tchem Stimulator of interferon genes protein (0 Activities)

Discover Target: TMEM173

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HFF (3142 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

MEF (1005 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Sting1 Stimulator of interferon genes protein (255 Activities)

Discover Target: Sting1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
INCHI	InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)
InChi Key	UJZDIKVQFMCLBE-UHFFFAOYSA-N
Canonical SMILES	CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32
Isomeric SMILES	CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32
PubChem CID	7616033
Molecular Weight	279.34

Database links

PubChem CID	7616033
CAS Registry No.	941987-60-6

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot Number	Certificate Type	Date	Item
J2120385	Certificate of Analysis	Aug 14, 2024	H287635
J2120383	Certificate of Analysis	Aug 09, 2024	H287635
D2423369	Certificate of Analysis	Apr 11, 2024	H287635
D2423371	Certificate of Analysis	Apr 11, 2024	H287635
D2423372	Certificate of Analysis	Apr 11, 2024	H287635
D2423373	Certificate of Analysis	Apr 11, 2024	H287635
D2423374	Certificate of Analysis	Apr 11, 2024	H287635
D2423375	Certificate of Analysis	Apr 11, 2024	H287635
D2423376	Certificate of Analysis	Apr 11, 2024	H287635
D2423377	Certificate of Analysis	Apr 11, 2024	H287635
D2315353	Certificate of Analysis	Jun 29, 2021	H287635

Show more⌵

Chemical and Physical Properties

Solubility	Insoluble in water,Dissolved in DMSO, maximum concentration (mg/ml): 125, maximum concentration (mm): 447.48 (ultrasonic treatment required)

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

Alternative Products

Citations of This Product

1. Xiaohua Xie, Xiaofeng Wu, Dongsheng Zhao, Ying Liu, Qiyue Du, Yitian Li, Yaping Xu, Yuhang Li, Yan Qiu, Yungang Yang. (2023) Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway. PHARMACOLOGICAL RESEARCH, 187 (106577). [PMID:36435270]

References

1. Haag SM, Gulen MF, Reymond L, Gibelin A, Abrami L, Decout A, Heymann M, van der Goot FG, Turcatti G, Behrendt R et al.. (2018) Targeting STING with covalent small-molecule inhibitors.. Nature, 559 (7713): (269-273). [PMID:29973723]
2. Di Domizio J, Gulen MF, Saidoune F, Thacker VV, Yatim A, Sharma K, Nass T, Guenova E, Schaller M, Conrad C et al.. (2022) The cGAS-STING pathway drives type I IFN immunopathology in COVID-19.. Nature, 129 (3): (589-97). [PMID:35045565]
3. Xiaohua Xie, Xiaofeng Wu, Dongsheng Zhao, Ying Liu, Qiyue Du, Yitian Li, Yaping Xu, Yuhang Li, Yan Qiu, Yungang Yang. (2023) Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway. PHARMACOLOGICAL RESEARCH, 187 (106577). [PMID:36435270]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.