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H-Trp-Glu-OH - ≥98%, high purity , CAS No.36099-95-3

≥98%

CAS#: 36099-95-3
Formula: C₁₆H₁₉N₃O₅
Molecular Weight: 333.34
PubChem CID: 7009663

Item Number

H303545

Grouped product items
SKU	Size	Availability	Price
H303545-10mg	10mg	In stock	$27.90
H303545-50mg	50mg	In stock	$104.90
H303545-250mg	250mg	In stock	$470.90
H303545-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,692.90

Selective, cell-permeable, reversible PPARγ antagonist.

Basic Description

Synonyms	tryptophanyl-glutamic acid \| HY-128487 \| Q27144978 \| WE \| L-tryptophyl-L-glutamic acid \| l-tryptophanyl-l-glutamic acid \| AS-75750 \| H-Trp-Glu-OH \| (2S)-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]pentanedioic acid \| Tryptophyl-Glutamate \| (S)-2-[(S
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Selective, cell-permeable, reversible PPARγ antagonist (K d = 8 μM). Inhibits activity of PPARγ agonist Rosiglitazone . Active in vivo .
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Product Application： A cell-permeable dipeptide that acts as a selective and reversible peroxisome proliferator-activated receptor antagonist

Associated Targets(Human)

PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

Discover Target: PPARG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPARA Tclin Peroxisome proliferator-activated receptor alpha (9197 Activities)

Discover Target: PPARA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2S)-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]pentanedioic acid
INCHI	InChI=1S/C16H19N3O5/c17-11(7-9-8-18-12-4-2-1-3-10(9)12)15(22)19-13(16(23)24)5-6-14(20)21/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/m0/s1
InChi Key	PWIQCLSQVQBOQV-AAEUAGOBSA-N
Canonical SMILES	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)NC(CCC(=O)O)C(=O)O)N
Isomeric SMILES	C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)O)N
PubChem CID	7009663
Molecular Weight	333.34

Certificates

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4 results found

Lot Number	Certificate Type	Date	Item
B2217260	Certificate of Analysis	Dec 05, 2024	H303545
B2217339	Certificate of Analysis	Dec 05, 2024	H303545
B2217340	Certificate of Analysis	Dec 05, 2024	H303545
B2217359	Certificate of Analysis	Dec 05, 2024	H303545

Solubility

insoluble in EtOH; ≥14.35 mg/mL in DMSO; ≥5.76 mg/mL in H2O with ultrasonic

Sensitivity

Light sensitive

References

1. Meng QQ et al.. (2018) Combined Rosiglitazone and Forskolin Have Neuroprotective Effects in SD Rats after Spinal Cord Injury.. PPAR Res, 2018 (3897478). [PMID:30034460]
2. Meng QQ et al.. (2019) PPAR-? Activation Exerts an Anti-inflammatory Effect by Suppressing the NLRP3 Inflammasome in Spinal Cord-Derived Neurons.. Mediators Inflamm, 2019 (6386729). [PMID:31015796]
3. Hu L et al.. (2020) Rosiglitazone ameliorates radiation-induced intestinal inflammation in rats by inhibiting NLRP3 inflammasome and TNF-a production.. J Radiat Res, 61 (6): (842-850). [PMID:32876675]

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H-Trp-Glu-OH - ≥98%, high purity , CAS No.36099-95-3

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action