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HBX 41108 - ≥98%(HPLC), high purity , CAS No.924296-39-9

  • ≥98%(HPLC)
Item Number
H288426
Grouped product items
SKUSizeAvailabilityPrice Qty
H288426-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$136.90
H288426-10mg
10mg
In stock
$189.90
H288426-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$510.90
H288426-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$919.90
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Selective USP7 inhibitor

Basic Description

Synonyms7-CHLORO-9-OXOINDENO[1,2-B]PYRAZINE-2,3-DICARBONITRILE | HBX 41108 | 9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 7-chloro-9-oxo- | A903088 | HY-101666 | SCHEMBL1512560 | C7JH7KSP8Z | HBX41108; HBX-41108; HBX 41,108; HBX-41,108; HBX41,108 | 7-Chloro-9-oxo
Specifications & Purity≥98%(HPLC)
Biochemical and Physiological MechanismsInhibitor of ubiquitin-specific protease (USP) 7 activity (IC50= 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50= 0.8μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Associated Targets(Human)

USP7 Tchem Ubiquitin carboxyl-terminal hydrolase 7 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
USP8 Tchem Ubiquitin carboxyl-terminal hydrolase 8 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
USP7 Tchem Ubiquitin carboxyl-terminal hydrolase 7 (837 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP47 Tchem Ubiquitin carboxyl-terminal hydrolase 47 (99 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 7-chloro-9-oxoindeno[1,2-b]pyrazine-2,3-dicarbonitrile
INCHI InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H
InChi Key BIGPXXAUSQLTQR-UHFFFAOYSA-N
Canonical SMILES C1=CC2=C(C=C1Cl)C(=O)C3=NC(=C(N=C23)C#N)C#N
Isomeric SMILES C1=CC2=C(C=C1Cl)C(=O)C3=NC(=C(N=C23)C#N)C#N
PubChem CID 16065773
Molecular Weight 266.64

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
K2302081Certificate of AnalysisOct 17, 2023 H288426
K2302083Certificate of AnalysisOct 17, 2023 H288426
K2302084Certificate of AnalysisOct 17, 2023 H288426
K2302085Certificate of AnalysisOct 17, 2023 H288426
K2302125Certificate of AnalysisOct 17, 2023 H288426

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 26.66, Max Conc. mM: 100
SensitivityMoisture sensitive

Related Documents

 SDS

 Specification Sheet

Solution Calculators

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