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HBX 41108 - ≥98%(HPLC), high purity , CAS No.924296-39-9

≥98%(HPLC)

CAS#: 924296-39-9
Formula: C₁₃H₃ClN₄O
Molecular Weight: 266.64
PubChem CID: 16065773

Item Number

H288426

Grouped product items
SKU	Size	Availability	Price
H288426-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$136.90
H288426-10mg	10mg	In stock	$189.90
H288426-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$510.90
H288426-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$919.90

Selective USP7 inhibitor

Basic Description

Synonyms	924296-39-9 \| 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile \| HBX 41108 \| HBX-41108 \| HBX41108 \| C7JH7KSP8Z \| UNII-C7JH7KSP8Z \| 7-Chloro-9-oxo-9H-indeno[1,2-b]-pyrazine-2,3-dicarbonitrile \| CHEMBL2398212 \| 7-Chloro-9-oxo-9H-indeno(1,2-b)pyrazine-2,3-dicarbonit
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50= 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50= 0.8μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

USP7 Tchem Ubiquitin carboxyl-terminal hydrolase 7 (2 Activities)

Discover Target: USP7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

USP8 Tchem Ubiquitin carboxyl-terminal hydrolase 8 (1 Activities)

Discover Target: USP8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

USP7 Tchem Ubiquitin carboxyl-terminal hydrolase 7 (837 Activities)

Discover Target: USP7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP47 Tchem Ubiquitin carboxyl-terminal hydrolase 47 (99 Activities)

Discover Target: USP47

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP8 Tchem Ubiquitin carboxyl-terminal hydrolase 8 (245 Activities)

Discover Target: USP8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	7-chloro-9-oxoindeno[1,2-b]pyrazine-2,3-dicarbonitrile
INCHI	InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H
InChi Key	BIGPXXAUSQLTQR-UHFFFAOYSA-N
Canonical SMILES	C1=CC2=C(C=C1Cl)C(=O)C3=NC(=C(N=C23)C#N)C#N
Isomeric SMILES	C1=CC2=C(C=C1Cl)C(=O)C3=NC(=C(N=C23)C#N)C#N
PubChem CID	16065773
Molecular Weight	266.64

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
K2302081	Certificate of Analysis	Oct 17, 2023	H288426
K2302083	Certificate of Analysis	Oct 17, 2023	H288426
K2302084	Certificate of Analysis	Oct 17, 2023	H288426
K2302085	Certificate of Analysis	Oct 17, 2023	H288426
K2302125	Certificate of Analysis	Oct 17, 2023	H288426

Solubility

Solvent:DMSO, Max Conc. mg/mL: 26.66, Max Conc. mM: 100

Sensitivity

Moisture sensitive

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