Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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H276135-1mg | 1mg | In stock | $228.90 | |
H276135-5mg | 5mg | In stock | $1,026.90 |
Potent, cell-permeable histone deacetylase (HDAC) inhibitor
Synonyms | HC Toxin | HC-Toxin | 83209-65-8 | 17NL0QLS6P | helminthosporium carbonum toxin i | (3S,6R,9S,12R)-6,9-dimethyl-3-[6-[(2S)-oxiran-2-yl]-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone | UNII-17NL0QLS6P | Helminthosporium carbonum toxin | HC-TOXIN |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Potent, cell-permeable histone deacetylase (HDAC) inhibitor. E. tenella HDAC (IC 50 = 30 nM), Human HDAC 11 (IC 50 = 430 nM). Induces apoptosis. Displays antiprotozoal and antitumorigenic activity. Active in vitro and in vivo . |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
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IUPAC Name | (3S,6R,9S,12R)-6,9-dimethyl-3-[6-[(2S)-oxiran-2-yl]-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone |
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INCHI | InChI=1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)/t12-,13+,14-,15+,17-/m0/s1 |
InChi Key | GNYCTMYOHGBSBI-SVZOTFJBSA-N |
Canonical SMILES | CC1C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C)CCCCCC(=O)C3CO3 |
Isomeric SMILES | C[C@@H]1C(=O)N[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@H](C(=O)N1)C)CCCCCC(=O)[C@@H]3CO3 |
PubChem CID | 13889849 |
Molecular Weight | 436.5 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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L2315066 | Certificate of Analysis | Sep 06, 2024 | H276135 |
H2223394 | Certificate of Analysis | Jun 07, 2023 | H276135 |
H2223292 | Certificate of Analysis | Jun 06, 2023 | H276135 |
Solubility | Soluble in DMSO |
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Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H300:Fatal if swallowed |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |