HC Toxin - ≥98%, high purity , CAS No.83209-65-8

  • ≥98%
Item Number
H276135
Grouped product items
SKUSizeAvailabilityPrice Qty
H276135-1mg
1mg
In stock
$228.90
H276135-5mg
5mg
In stock
$1,026.90

Potent, cell-permeable histone deacetylase (HDAC) inhibitor

Basic Description

SynonymsHC Toxin | HC-Toxin | 83209-65-8 | 17NL0QLS6P | helminthosporium carbonum toxin i | (3S,6R,9S,12R)-6,9-dimethyl-3-[6-[(2S)-oxiran-2-yl]-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone | UNII-17NL0QLS6P | Helminthosporium carbonum toxin | HC-TOXIN
Specifications & Purity≥98%
Biochemical and Physiological MechanismsPotent, cell-permeable histone deacetylase (HDAC) inhibitor. E. tenella HDAC (IC 50 = 30 nM), Human HDAC 11 (IC 50 = 430 nM). Induces apoptosis. Displays antiprotozoal and antitumorigenic activity. Active in vitro and in vivo .
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets(Human)

HDAC8 Tclin Histone deacetylase 8 (4516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HDAC2 Tclin Histone deacetylase 2 (3971 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HDAC3 Tclin Histone deacetylase 3 (3654 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac1 Histone deacetylase 1 (93 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HD1 Histone deacetylase (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
hda106 Histone deacetylase HD2 (351 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (3S,6R,9S,12R)-6,9-dimethyl-3-[6-[(2S)-oxiran-2-yl]-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
INCHI InChI=1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)/t12-,13+,14-,15+,17-/m0/s1
InChi Key GNYCTMYOHGBSBI-SVZOTFJBSA-N
Canonical SMILES CC1C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C)CCCCCC(=O)C3CO3
Isomeric SMILES C[C@@H]1C(=O)N[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@H](C(=O)N1)C)CCCCCC(=O)[C@@H]3CO3
PubChem CID 13889849
Molecular Weight 436.5

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot NumberCertificate TypeDateItem
L2315066Certificate of AnalysisSep 06, 2024 H276135
H2223394Certificate of AnalysisJun 07, 2023 H276135
H2223292Certificate of AnalysisJun 06, 2023 H276135

Chemical and Physical Properties

SolubilitySoluble in DMSO

Safety and Hazards(GHS)

Pictogram(s) GHS06
Signal Danger
Hazard Statements

H300:Fatal if swallowed

Precautionary Statements

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

Related Documents

Solution Calculators