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HDAC3-IN-T247 - 95%, high purity , CAS No.1451042-18-4

≥95%

CAS#: 1451042-18-4
Formula: C₂₁H₁₉N₅OS
Molecular Weight: 389.48
PubChem CID: 71721946

Item Number

N159027

Grouped product items
SKU	Size	Availability	Price
N159027-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$49.90
N159027-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$159.90
N159027-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$499.90
N159027-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,199.90

View related series

Five-Membered Heterocyclic Compounds HDAC thiophenes

Basic Description

Synonyms	1451042-18-4 \| CS-0082357 \| D88539 \| T247 \| HDAC3INT247 \| HDAC3-IN-T247 \| HDAC3 inhibitor T247 \| N-(2-aminophenyl)-4-[1-(2-thiophen-3-ylethyl)triazol-4-yl]benzamide \| T 247 \| MFCD29089340 \| HDAC3 IN T247 \| HDAC3 inhibitor-T247 \| BIC04218 \| SCHEMBL18208054
Specifications & Purity	≥95%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Product Description	HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells.

Associated Targets

HDAC4 Tclin Histone deacetylase 4 0 Activities

Discover Target: HDAC4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC1 Tclin Histone deacetylase 1 0 Activities

Discover Target: HDAC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC2 Tclin Histone deacetylase 2 0 Activities

Discover Target: HDAC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC8 Tclin Histone deacetylase 8 0 Activities

Discover Target: HDAC8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC5 Tclin Histone deacetylase 5 0 Activities

Discover Target: HDAC5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC3 Tclin Histone deacetylase 3 1 Activities

Discover Target: HDAC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-(2-aminophenyl)-4-[1-(2-thiophen-3-ylethyl)triazol-4-yl]benzamide
INCHI	InChI=1S/C21H19N5OS/c22-18-3-1-2-4-19(18)23-21(27)17-7-5-16(6-8-17)20-13-26(25-24-20)11-9-15-10-12-28-14-15/h1-8,10,12-14H,9,11,22H2,(H,23,27)
InChi Key	LBLSLSOENGWIHL-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)C3=CN(N=N3)CCC4=CSC=C4
Isomeric SMILES	C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)C3=CN(N=N3)CCC4=CSC=C4
PubChem CID	71721946
Molecular Weight	389.48

Certificates

Certificate of Analysis(COA)

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8 results found

Lot Number	Certificate Type	Date	Item
G2417440	Certificate of Analysis	Mar 20, 2024	N159027
G2417441	Certificate of Analysis	Mar 20, 2024	N159027
G2417442	Certificate of Analysis	Mar 20, 2024	N159027
G2417446	Certificate of Analysis	Mar 20, 2024	N159027
G2417458	Certificate of Analysis	Mar 20, 2024	N159027
G2417459	Certificate of Analysis	Mar 20, 2024	N159027
G2417475	Certificate of Analysis	Mar 20, 2024	N159027
G2417544	Certificate of Analysis	Mar 20, 2024	N159027

Sensitivity

Air Sensitive,Heat Sensitive

Melt Point(°C)

236 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P264:Wash hands [and …] thoroughly after handling. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help.

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