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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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H655008-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $145.90 |
Specifications & Purity | 10mM in DMSO |
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Biochemical and Physiological Mechanisms | HDAC8-IN-1 is a HDAC8 inhibitor with an IC 50 of 27.2 nM. |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | HDAC8-IN-1 is a HDAC8 inhibitor with an IC 50 of 27.2 nM. In Vitro HDAC8-IN-1 is a HDAC8 inhibitor with an IC 50 of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:HDAC8 27.2 nM (IC 50 ) |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Canonical SMILES | COC1=CC(=C(C=C1)C=CC(=O)NO)C2=CC=C(C=C2)C3=CC=CC=C3 |
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Molecular Weight | 345.39 |
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