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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Basic Description
| Synonyms | Olean-12-en-28-oic acid, 3.beta.,23-dihydroxy- | AKOS016036289 | BDBM50442880 | CCG-269472 | (3-beta,4-alpha)-3,23-Dihydroxyolean-12-en-28-oic acid | (4AS,6AS,6BR,8AR,9R,10S,12AR,12BR,14BS)-10-HYDROXY-9-(HYDROXYMETHYL)-2,2,6A,6B,9,12A-HEXAMETHYL-1,2,3,4,4 |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Saponin. Anti-inflammatory. |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Hederagenin是三萜皂苷，能够抑制细胞中由于LPS刺激引起的 iNOS, COX-2,和 NF-κB的表达。 |
Associated Targets(Human)
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2 Activities)
F3 Tclin Tissue factor (1 Activities)
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EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
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ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)
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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
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PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
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ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
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NQO1 Tchem Quinone reductase 1 (1746 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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A-375 (9258 Activities)
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AGS (1999 Activities)
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BGC-823 (3035 Activities)
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DLD-1 (17511 Activities)
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HL-60 (67320 Activities)
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HT-29 (80576 Activities)
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M14 (47487 Activities)
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MCF7 (126967 Activities)
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NCI-H1975 (4994 Activities)
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MKN-45 (2102 Activities)
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SW-1736 (356 Activities)
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A549 (127892 Activities)
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FaDu (1726 Activities)
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HepG2 (196354 Activities)
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A2780 (11979 Activities)
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KB (17409 Activities)
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HeLa (62764 Activities)
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MDA-MB-231 (73002 Activities)
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8505C (583 Activities)
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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
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PRKAA2 Tchem AMP-activated protein kinase, AMPK (12273 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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USP7 Tchem Ubiquitin carboxyl-terminal hydrolase 7 (837 Activities)
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NCI-H187 (598 Activities)
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L02 (4864 Activities)
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Associated Targets(non-human)
Coagulation factor III (5 Activities)
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Abcb1b P-glycoprotein 1 (174 Activities)
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Leishmania infantum (5912 Activities)
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Carassius auratus (65 Activities)
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Hepatitis C virus (23859 Activities)
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NIH3T3 (5395 Activities)
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Oreochromis (28 Activities)
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Pomacea canaliculata (20 Activities)
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | (4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-10-hydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid |
|---|---|
| INCHI | InChI=1S/C30H48O4/c1-25(2)13-15-30(24(33)34)16-14-28(5)19(20(30)17-25)7-8-22-26(3)11-10-23(32)27(4,18-31)21(26)9-12-29(22,28)6/h7,20-23,31-32H,8-18H2,1-6H3,(H,33,34)/t20-,21+,22+,23-,26-,27-,28+,29+,30-/m0/s1 |
| InChi Key | PGOYMURMZNDHNS-MYPRUECHSA-N |
| Canonical SMILES | CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)CO)O)C)C)C2C1)C)C(=O)O)C |
| Isomeric SMILES | C[C@]12CC[C@@H]([C@@]([C@@H]1CC[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)C)C)(C)CO)O |
| WGK Germany | 3 |
| PubChem CID | 73299 |
| Molecular Weight | 472.7 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Safety and Hazards(GHS)
| WGK Germany | 3 |
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Related Documents
Citations of This Product
| 1. Li Pengfei, Peng Jun, Li Yuexin, Gong Lili, Lv Yali, Liu He, Zhang Tianhong, Yang Song, Liu Hongchuan, Li Jinglai, Liu Lihong. (2021) Pharmacokinetics, Bioavailability, Excretion and Metabolism Studies of Akebia Saponin D in Rats: Causes of the Ultra-Low Oral Bioavailability and Metabolic Pathway. Frontiers in Pharmacology, 12 [PMID:33935711] [10.3389/fphar.2021.621003] |
| 2. Junyan Wang, Minmin Huang, Haihong Hu, Lushan Yu, Su Zeng. (2014) Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs. FOOD CHEMISTRY, 164 (74). [PMID:24996308] [10.1016/j.foodchem.2014.05.004] |
References
| 1. Li Pengfei, Peng Jun, Li Yuexin, Gong Lili, Lv Yali, Liu He, Zhang Tianhong, Yang Song, Liu Hongchuan, Li Jinglai, Liu Lihong. (2021) Pharmacokinetics, Bioavailability, Excretion and Metabolism Studies of Akebia Saponin D in Rats: Causes of the Ultra-Low Oral Bioavailability and Metabolic Pathway. Frontiers in Pharmacology, 12 [PMID:33935711] [10.3389/fphar.2021.621003] |
| 2. Junyan Wang, Minmin Huang, Haihong Hu, Lushan Yu, Su Zeng. (2014) Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs. FOOD CHEMISTRY, 164 (74). [PMID:24996308] [10.1016/j.foodchem.2014.05.004] |