Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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H274892-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $147.90 |
Potent, irreversible, selective inhibitor of Ca 2+ independent PLA 2
Synonyms | SR-01000075707-1 | 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one | HMS3649C04 | 4-Monochlorodiphenyl oxide | 6-Bromomethylene-3-naphthalen-1-yl-tetrahydro-pyran-2-one | NCGC00015141-02 | Carbamic acid, methyl-, o-(1,3-dioxolan-2-yl)phenyl |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Potent, irreversible, selective inhibitor of Ca 2+ independent PLA 2 (IC 50 = 1 μM). Active in vivo. |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | CHANNEL BLOCKER |
Mechanism of action | Channel blocker of TRPC5 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
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IUPAC Name | (6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one |
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INCHI | InChI=1S/C16H13BrO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+ |
InChi Key | BYUCSFWXCMTYOI-ZRDIBKRKSA-N |
Canonical SMILES | C1CC(=CBr)OC(=O)C1C2=CC=CC3=CC=CC=C32 |
Isomeric SMILES | C1C/C(=C\Br)/OC(=O)C1C2=CC=CC3=CC=CC=C32 |
PubChem CID | 5940264 |
Molecular Weight | 317.2 |
CAS Registry No. | 88070-98-8 |
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PubChem CID | 5940264 |
ChEMBL Ligand | CHEMBL6206 |
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Solubility | Soluble in DMSO to 75 mM |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |