Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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H104302-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $21.90 | |
H104302-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $75.90 | |
H104302-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $264.90 | |
H104302-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $739.90 |
Nuclear stain
Synonyms | Hematoxylin, for microscopy (Hist.), indicator (pH 5.0-6.0) | NSC 270085 | NCGC00160144-01 | Q1146112 | NCI-C55889 | HSDB 4174 | Natural Black 1 | CHEBI:38384 | Hydroxybrasilin | LMPK12100063 | DTXSID8020678 | WZUVPPKBWHMQCE-XJKSGUPXSA-N | (Z)-2-dodecened |
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Specifications & Purity | high-purity, ≥99%(HPLC) |
Biochemical and Physiological Mechanisms | Nuclear stain. Oxidizes to haematein and form strongly colored complexes with metal ions ( Fe(III) and Al(III)). |
Shipped In | Normal |
Grade | high-purity |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Hematoxylin is a basophilic dye extracted from the tree Heamatoxylum campechianum. It specifically binds to acidic compounds and thus is useful for staining cell nuclei which contain acidic substances: DNA and RNA. Hematoxylin, when oxidized forms hematein, which has thick pale blue purple colour. Hematoxylin is often used along with eosin, in histological study under light microscope. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (6aS,11bR)-7,11b-dihydro-6H-indeno[2,1-c]chromene-3,4,6a,9,10-pentol |
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INCHI | InChI=1S/C16H14O6/c17-10-2-1-8-13-9-4-12(19)11(18)3-7(9)5-16(13,21)6-22-15(8)14(10)20/h1-4,13,17-21H,5-6H2/t13-,16+/m0/s1 |
InChi Key | WZUVPPKBWHMQCE-XJKSGUPXSA-N |
Canonical SMILES | C1C2=CC(=C(C=C2C3C1(COC4=C3C=CC(=C4O)O)O)O)O |
Isomeric SMILES | C1C2=CC(=C(C=C2[C@H]3[C@@]1(COC4=C3C=CC(=C4O)O)O)O)O |
WGK Germany | 3 |
RTECS | MH7875000 |
PubChem CID | 442514 |
Molecular Weight | 302.28(as Anhydrous) |
Beilstein | 17(2)273 |
Reaxy-Rn | 7383764 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
K2009077 | Certificate of Analysis | Aug 16, 2024 | H104302 |
C2416151 | Certificate of Analysis | Mar 08, 2024 | H104302 |
C2416154 | Certificate of Analysis | Mar 08, 2024 | H104302 |
K2314529 | Certificate of Analysis | Nov 02, 2023 | H104302 |
K2314533 | Certificate of Analysis | Nov 02, 2023 | H104302 |
F23281218 | Certificate of Analysis | May 16, 2023 | H104302 |
F2328926 | Certificate of Analysis | May 16, 2023 | H104302 |
F2328956 | Certificate of Analysis | May 16, 2023 | H104302 |
E1920097 | Certificate of Analysis | Mar 08, 2023 | H104302 |
E23061282 | Certificate of Analysis | Dec 07, 2022 | H104302 |
E23061290 | Certificate of Analysis | Dec 07, 2022 | H104302 |
E23061303 | Certificate of Analysis | Dec 07, 2022 | H104302 |
I2212009 | Certificate of Analysis | Jul 18, 2022 | H104302 |
I2212010 | Certificate of Analysis | Jul 18, 2022 | H104302 |
K2223253 | Certificate of Analysis | Nov 11, 2021 | H104302 |
Sensitivity | Light Sensitive |
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Melt Point(°C) | 200°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | MH7875000 |
Reaxy-Rn | 7383764 |
Merck Index | 4637 |
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1. Wei Chen, Haotian Yu, Chengbiao Sun, Mingxin Dong, Na Zhao, Yan Wang, Kaikai Yu, Jianxu Zhang, Na Xu, Wensen Liu. (2023) γ-Bungarotoxin impairs the vascular endothelial barrier function by inhibiting integrin α5. TOXICOLOGY LETTERS, 383 (177). [PMID:37392970] [10.1016/j.toxlet.2023.06.009] |
2. Zhaowei Wen, Huiying Sun, Zhihua Zhang, Yannan Zheng, Siting Zheng, Jianping Bin, Yulin Liao, Min Shi, Rui Zhou, Wangjun Liao. (2023) High baseline tumor burden-associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2-STAT3-PD-L1 pathway. Cancer Communications, 43 (5): (562-581). [PMID:37031362] [10.1002/cac2.12420] |
3. Yifei Jiang, Qinghe Wu, Mengfei Hou, Wangxi Hai, Min Zhang, Biao Li, Chunfu Zhang. (2023) pH-sensitive gold nanoclusters labeling with radiometallic nuclides for diagnosis and treatment of tumor. Materials Today Bio, 19 (100578). [PMID:36880082] [10.1016/j.mtbio.2023.100578] |
4. Yi Li, Wenyan She, Tangxi Guo, Tianhe Huang, Yixin liu, Pan Liu, Xiaoran Xu, Xinyu Wang, Miao Wang, Chaochao Yu, Yi Liu, Yongchang Wei. (2023) The organic arsenical-derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS-dependent ER stress. BIOCHEMICAL PHARMACOLOGY, 208 (115404). [PMID:36592709] [10.1016/j.bcp.2022.115404] |
5. Kaihao Wang, Min Zhou, Youhong Zhang, Yipeng Du, Peixin Li, Chang Guan, Zheng Huang. (2023) IRX2 activated by jumonji domain-containing protein 2A is crucial for cardiac hypertrophy and dysfunction in response to the hypertrophic stimuli. INTERNATIONAL JOURNAL OF CARDIOLOGY, 371 (332). [PMID:36181956] [10.1016/j.ijcard.2022.09.070] |
6. Weifang Wang, Yunfeng Li, Guojing Han, Aimin Li, Xiaomei Kong. (2022) Lactobacillus fermentum CECT5716 Alleviates the Inflammatory Response in Asthma by Regulating TLR2/TLR4 Expression. Frontiers in Nutrition, 9 (931427). [PMID:35911120] [10.3389/fnut.2022.931427] |
7. Zining Hao, Yuchu He, Jing Wang, Xuwu Zhang, Fei Ye, Ze Guan, Xiaokang Liu, Zhenhe Ma, Yi Yuan, Hongming Lou, Dawei Gao. (2022) Photocatalysis/enzymolysis-based biomimetic Schottky junction reduces tumor interstitial solid and fluid phases for deep-penetrating tumor therapy. CHEMICAL ENGINEERING JOURNAL, 446 (137196). [PMID:] [10.1016/j.cej.2022.137196] |
8. Chen Pan, Wu Hao, Yao Hongliang, Zhang Jiashuo, Fan Weiyang, Chen Zhen, Su Weiwei, Wang Yonggang, Li Peibo. (2022) Multi-Omics Analysis Reveals the Systematic Relationship Between Oral Homeostasis and Chronic Sleep Deprivation in Rats. Frontiers in Immunology, 13 [PMID:35432311] [10.3389/fimmu.2022.847132] |
9. Zhengrong Yin, Xiangli Zhang, Yan Bai, Yanwei Yang, Bin Liu, Zengjie Fan. (2022) Dissolvable and layered microneedles composed of hyaluronate/rbFGF/CPC effectively improve the treatment effect on recurrent aphthous ulcers. NEW JOURNAL OF CHEMISTRY, 46 (15): (7279-7289). [PMID:] [10.1039/D2NJ00054G] |
10. Xiaoping Wu, Qiujie Pang, Fuxiang Zhi, Xiaohong Mao, Yingbin Hu. (2022) Overexpression of long non-coding RNA ACTA2-AS1 inhibits the viability, proliferation, migration and invasion of colorectal cancer cells. TISSUE & CELL, 76 (101769). [PMID:35325674] [10.1016/j.tice.2022.101769] |
11. Hao Cheng, Zijun Jiang, Chenkai Sun, Zhen Wang, Guochen Han, Xin Chen, Tianyi Li, Zhechen Fan, Feng Zhang, Xiaoyu Yang, Lingyu Lv, Huaqing Zhang, Jianping Zhou, Yang Ding. (2022) Protein stabilized polymeric nanoparticles inspired relay drug delivery for tackling post-chemotherapeutic metastasis. CHEMICAL ENGINEERING JOURNAL, 427 (131672). [PMID:] [10.1016/j.cej.2021.131672] |
12. Ke Wang, Huina Hu, Wenbo Cui, Xuelian Zhang, Qi Tang, Nuan Liu, Xianyong Lan, Chuanying Pan. (2021) Palliative effects of metformin on testicular damage induced by triptolide in male rats. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 222 (112536). [PMID:34303043] [10.1016/j.ecoenv.2021.112536] |
13. Rong Shen, Yichang Yu, Rong Lan, Ran Yu, Ze Yuan, Zhining Xia. (2019) The cardiovascular toxicity induced by high doses of gatifloxacin and ciprofloxacin in zebrafish. ENVIRONMENTAL POLLUTION, 254 (112861). [PMID:31454568] [10.1016/j.envpol.2019.07.029] |
14. Pan Chen, Hongliang Yao, Weiwei Su, Yudong He, Keling Cheng, Yonggang Wang, Wei Peng, Peibo Li. (2019) Sleep deprivation worsened oral ulcers and delayed healing process in an experimental rat model. LIFE SCIENCES, 232 (116594). [PMID:31233761] [10.1016/j.lfs.2019.116594] |
15. Liang Huiyi, Peng Bo, Dong Cong, Liu Lixin, Mao Jiaji, Wei Song, Wang Xinlu, Xu Hanshi, Shen Jun, Mao Hai-Quan, Gao Xiaohu, Leong Kam W., Chen Yongming. (2018) Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation. Nature Communications, 9 (1): (1-14). [PMID:30327464] [10.1038/s41467-018-06603-5] |
16. Chang Liu, Peng Wang, Xueke Liu, Xiaotong Yi, Zhiqiang Zhou, Donghui Liu. (2018) Supramolecular fluorescent sensor array for simultaneous qualitative and quantitative analysis of quaternary ammonium herbicides. NEW JOURNAL OF CHEMISTRY, 42 (21): (17317-17322). [PMID:] [10.1039/C8NJ02954G] |
17. Shijie Li, Zhuoyue Song, Tingting Liu, Jian Liang, Jun Yuan, Zhanchi Xu, Zhanghua Sun, Xiaoping Lai, Qingping Xiong, Danyan Zhang. (2018) Polysaccharide from Ostrea rivularis attenuates reproductive oxidative stress damage via activating Keap1-Nrf2/ARE pathway. CARBOHYDRATE POLYMERS, 186 (321). [PMID:29455993] [10.1016/j.carbpol.2018.01.075] |
18. Tongliang Xia, Bin Huang, Shilei Ni, Lei Gao, Jiangang Wang, Jian Wang, Anjing Chen, Shaowei Zhu, Benlin Wang, Gang Li, Shugan Zhu, Xingang Li. (2017) The combination of db-cAMP and ChABC with poly(propylene carbonate) microfibers promote axonal regenerative sprouting and functional recovery after spinal cord hemisection injury. BIOMEDICINE & PHARMACOTHERAPY, 86 (354). [PMID:28011383] [10.1016/j.biopha.2016.12.045] |
19. Yuan-Peng Rui, Bo Liang, Fenglin Hu, Jie Xu, Yi-Feng Peng, Pei-Hao Yin, Yourong Duan, Chunfu Zhang, Hongchen Gu. (2016) Ultra-large-scale production of ultrasmall superparamagnetic iron oxide nanoparticles for T1-weighted MRI. RSC Advances, 6 (27): (22575-22585). [PMID:] [10.1039/C6RA00347H] |
20. Xue YL et al.. (2019) Silencing of STAT4 Protects Against Autoimmune Myocarditis by Regulating Th1/Th2 Immune Response via Inactivation of the NF-?B Pathway in Rats.. Inflammation, [PMID:30848408] |
21. Yaqin Liu,Tao Li,Hongshi Ma,Dong Zhai,Cuijun Deng,Jinwu Wang,Shangjun Zhuo,Jiang Chang,Chengtie Wu. (2018-04-16) 3D-printed scaffolds with bioactive elements-induced photothermal effect for bone tumor therapy.. Acta biomaterialia, 73 (531-546). [PMID:29656075] |
1. Wei Chen, Haotian Yu, Chengbiao Sun, Mingxin Dong, Na Zhao, Yan Wang, Kaikai Yu, Jianxu Zhang, Na Xu, Wensen Liu. (2023) γ-Bungarotoxin impairs the vascular endothelial barrier function by inhibiting integrin α5. TOXICOLOGY LETTERS, 383 (177). [PMID:37392970] [10.1016/j.toxlet.2023.06.009] |
2. Zhaowei Wen, Huiying Sun, Zhihua Zhang, Yannan Zheng, Siting Zheng, Jianping Bin, Yulin Liao, Min Shi, Rui Zhou, Wangjun Liao. (2023) High baseline tumor burden-associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2-STAT3-PD-L1 pathway. Cancer Communications, 43 (5): (562-581). [PMID:37031362] [10.1002/cac2.12420] |
3. Yifei Jiang, Qinghe Wu, Mengfei Hou, Wangxi Hai, Min Zhang, Biao Li, Chunfu Zhang. (2023) pH-sensitive gold nanoclusters labeling with radiometallic nuclides for diagnosis and treatment of tumor. Materials Today Bio, 19 (100578). [PMID:36880082] [10.1016/j.mtbio.2023.100578] |
4. Yi Li, Wenyan She, Tangxi Guo, Tianhe Huang, Yixin liu, Pan Liu, Xiaoran Xu, Xinyu Wang, Miao Wang, Chaochao Yu, Yi Liu, Yongchang Wei. (2023) The organic arsenical-derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS-dependent ER stress. BIOCHEMICAL PHARMACOLOGY, 208 (115404). [PMID:36592709] [10.1016/j.bcp.2022.115404] |
5. Kaihao Wang, Min Zhou, Youhong Zhang, Yipeng Du, Peixin Li, Chang Guan, Zheng Huang. (2023) IRX2 activated by jumonji domain-containing protein 2A is crucial for cardiac hypertrophy and dysfunction in response to the hypertrophic stimuli. INTERNATIONAL JOURNAL OF CARDIOLOGY, 371 (332). [PMID:36181956] [10.1016/j.ijcard.2022.09.070] |
6. Weifang Wang, Yunfeng Li, Guojing Han, Aimin Li, Xiaomei Kong. (2022) Lactobacillus fermentum CECT5716 Alleviates the Inflammatory Response in Asthma by Regulating TLR2/TLR4 Expression. Frontiers in Nutrition, 9 (931427). [PMID:35911120] [10.3389/fnut.2022.931427] |
7. Zining Hao, Yuchu He, Jing Wang, Xuwu Zhang, Fei Ye, Ze Guan, Xiaokang Liu, Zhenhe Ma, Yi Yuan, Hongming Lou, Dawei Gao. (2022) Photocatalysis/enzymolysis-based biomimetic Schottky junction reduces tumor interstitial solid and fluid phases for deep-penetrating tumor therapy. CHEMICAL ENGINEERING JOURNAL, 446 (137196). [PMID:] [10.1016/j.cej.2022.137196] |
8. Chen Pan, Wu Hao, Yao Hongliang, Zhang Jiashuo, Fan Weiyang, Chen Zhen, Su Weiwei, Wang Yonggang, Li Peibo. (2022) Multi-Omics Analysis Reveals the Systematic Relationship Between Oral Homeostasis and Chronic Sleep Deprivation in Rats. Frontiers in Immunology, 13 [PMID:35432311] [10.3389/fimmu.2022.847132] |
9. Zhengrong Yin, Xiangli Zhang, Yan Bai, Yanwei Yang, Bin Liu, Zengjie Fan. (2022) Dissolvable and layered microneedles composed of hyaluronate/rbFGF/CPC effectively improve the treatment effect on recurrent aphthous ulcers. NEW JOURNAL OF CHEMISTRY, 46 (15): (7279-7289). [PMID:] [10.1039/D2NJ00054G] |
10. Xiaoping Wu, Qiujie Pang, Fuxiang Zhi, Xiaohong Mao, Yingbin Hu. (2022) Overexpression of long non-coding RNA ACTA2-AS1 inhibits the viability, proliferation, migration and invasion of colorectal cancer cells. TISSUE & CELL, 76 (101769). [PMID:35325674] [10.1016/j.tice.2022.101769] |
11. Hao Cheng, Zijun Jiang, Chenkai Sun, Zhen Wang, Guochen Han, Xin Chen, Tianyi Li, Zhechen Fan, Feng Zhang, Xiaoyu Yang, Lingyu Lv, Huaqing Zhang, Jianping Zhou, Yang Ding. (2022) Protein stabilized polymeric nanoparticles inspired relay drug delivery for tackling post-chemotherapeutic metastasis. CHEMICAL ENGINEERING JOURNAL, 427 (131672). [PMID:] [10.1016/j.cej.2021.131672] |
12. Ke Wang, Huina Hu, Wenbo Cui, Xuelian Zhang, Qi Tang, Nuan Liu, Xianyong Lan, Chuanying Pan. (2021) Palliative effects of metformin on testicular damage induced by triptolide in male rats. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 222 (112536). [PMID:34303043] [10.1016/j.ecoenv.2021.112536] |
13. Rong Shen, Yichang Yu, Rong Lan, Ran Yu, Ze Yuan, Zhining Xia. (2019) The cardiovascular toxicity induced by high doses of gatifloxacin and ciprofloxacin in zebrafish. ENVIRONMENTAL POLLUTION, 254 (112861). [PMID:31454568] [10.1016/j.envpol.2019.07.029] |
14. Pan Chen, Hongliang Yao, Weiwei Su, Yudong He, Keling Cheng, Yonggang Wang, Wei Peng, Peibo Li. (2019) Sleep deprivation worsened oral ulcers and delayed healing process in an experimental rat model. LIFE SCIENCES, 232 (116594). [PMID:31233761] [10.1016/j.lfs.2019.116594] |
15. Liang Huiyi, Peng Bo, Dong Cong, Liu Lixin, Mao Jiaji, Wei Song, Wang Xinlu, Xu Hanshi, Shen Jun, Mao Hai-Quan, Gao Xiaohu, Leong Kam W., Chen Yongming. (2018) Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation. Nature Communications, 9 (1): (1-14). [PMID:30327464] [10.1038/s41467-018-06603-5] |
16. Chang Liu, Peng Wang, Xueke Liu, Xiaotong Yi, Zhiqiang Zhou, Donghui Liu. (2018) Supramolecular fluorescent sensor array for simultaneous qualitative and quantitative analysis of quaternary ammonium herbicides. NEW JOURNAL OF CHEMISTRY, 42 (21): (17317-17322). [PMID:] [10.1039/C8NJ02954G] |
17. Shijie Li, Zhuoyue Song, Tingting Liu, Jian Liang, Jun Yuan, Zhanchi Xu, Zhanghua Sun, Xiaoping Lai, Qingping Xiong, Danyan Zhang. (2018) Polysaccharide from Ostrea rivularis attenuates reproductive oxidative stress damage via activating Keap1-Nrf2/ARE pathway. CARBOHYDRATE POLYMERS, 186 (321). [PMID:29455993] [10.1016/j.carbpol.2018.01.075] |
18. Tongliang Xia, Bin Huang, Shilei Ni, Lei Gao, Jiangang Wang, Jian Wang, Anjing Chen, Shaowei Zhu, Benlin Wang, Gang Li, Shugan Zhu, Xingang Li. (2017) The combination of db-cAMP and ChABC with poly(propylene carbonate) microfibers promote axonal regenerative sprouting and functional recovery after spinal cord hemisection injury. BIOMEDICINE & PHARMACOTHERAPY, 86 (354). [PMID:28011383] [10.1016/j.biopha.2016.12.045] |
19. Yuan-Peng Rui, Bo Liang, Fenglin Hu, Jie Xu, Yi-Feng Peng, Pei-Hao Yin, Yourong Duan, Chunfu Zhang, Hongchen Gu. (2016) Ultra-large-scale production of ultrasmall superparamagnetic iron oxide nanoparticles for T1-weighted MRI. RSC Advances, 6 (27): (22575-22585). [PMID:] [10.1039/C6RA00347H] |
20. Xue YL et al.. (2019) Silencing of STAT4 Protects Against Autoimmune Myocarditis by Regulating Th1/Th2 Immune Response via Inactivation of the NF-?B Pathway in Rats.. Inflammation, [PMID:30848408] |
21. Yaqin Liu,Tao Li,Hongshi Ma,Dong Zhai,Cuijun Deng,Jinwu Wang,Shangjun Zhuo,Jiang Chang,Chengtie Wu. (2018-04-16) 3D-printed scaffolds with bioactive elements-induced photothermal effect for bone tumor therapy.. Acta biomaterialia, 73 (531-546). [PMID:29656075] |