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heme , CAS No.14875-96-8, Agonist of Rev-Erb-α;Agonist of Rev-Erb-β

24 Citations

Moligand™

CAS#: 14875-96-8
Formula: C₃₄H₃₂FeN₄O₄²
Molecular Weight: 616.49
PubChem CID: 26945

Item Number

H610806

Grouped product items
SKU	Size	Availability	Price	Qty
H610806-25μg	25μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
H610806-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,334.90

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Rev-Erb-α Agonist Rev-Erb-β Agonist

Basic Description

Synonyms	heme \| protoheme \| heme b \| 14875-96-8 \| ferroprotoporphyrin \| Ferroheme \| Reduced hematin \| Haem \| protoheme IX \| Iron protoporphyrin ix \| hematin \| Protohaem \| Ferrous protoheme \| Iron protoporphyrin \| Ferrous protoheme IX \| Ferroprotoporphyrin IX \| 42VZT0U6YR \| Iron(II) protoporphyrin
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of Rev-Erb-α;Agonist of Rev-Erb-β

Associated Targets(Human)

NR1D1 Tchem Nuclear receptor subfamily 1 group D member 1 (0 Activities)

Discover Target: NR1D1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR1D2 Tchem Nuclear receptor subfamily 1 group D member 2 (1 Activities)

Discover Target: NR1D2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+)
INCHI	InChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2
InChi Key	KABFMIBPWCXCRK-UHFFFAOYSA-L
Canonical SMILES	CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C)C=C)C)C=C)C)CCC(=O)O)CCC(=O)O.[Fe+2]
Isomeric SMILES	CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C)C=C)C)C=C)C)CCC(=O)O)CCC(=O)O.[Fe+2]
PubChem CID	26945
Molecular Weight	616.49

Database links

CAS Registry No.	14875-96-8
Wikipedia	Heme
ChEBI	CHEBI:30413
PubChem CID	26945

Certificates

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Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yuxiang Zhou, Yanyun Wang, Mengyuan Song, Lanrui Jiang, Chaoran Sun, Shuangshuang Wang, Hewen Yao, Zefei Wang, Xindi Wang, Chunhui Liu, Haibo Luo, Feng Song. (2024) A high-throughput droplet digital PCR system aiming eight DNA methylation targets for age prediction. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 240 (115943). [PMID:38181558] [10.1016/j.jpba.2023.115943]
2. Meng Shi, Demin Kong, Hui Zhang, Deming Rao, Tianlong Zhao, Jing Yang, Zhanzhi Liu, Sheng Chen, Fengshan Zhang, Jing Wu, Lei Wang. (2024) Enhancing the heterologous expression of latex clearing protein from Streptomyces sp. strain K30 in Escherichia coli through fermentation condition optimization and molecular modification. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 254 (127995). [PMID:37949282] [10.1016/j.ijbiomac.2023.127995]
3. Tao Zhan, Xiao-Zhen Feng, Yun-Yun Cheng, Guo-Cheng Han, Zhencheng Chen, Heinz-Bernhard Kraatz. (2023) Electrochemical sensor for ultrasensitive sensing of biotin based on heme conjugated with gold nanoparticles and its electrooxidation mechanism. FOOD CHEMISTRY, 429 (136997). [PMID:37516051] [10.1016/j.foodchem.2023.136997]
4. Guo-Cheng Han, Jiating Hou, Zong-Li Huang, Xiao-Zhen Feng, Zhencheng Chen, Wenxiang Xiao, Shuang Li. (2017) Electrochemical Behaviors of Ferrocene Dicarboxylate and its Application for Heme Detection. International Journal of Electrochemical Science, 12 (6245). [PMID:] [10.20964/2017.07.69]
5. Linlin Gao, Lin Zhang, Huan Liu, Jielun Hu. (2023) In vitro gastrointestinal digestion of whole grain noodles supplemented with soluble dietary fiber and their effects on children fecal microbiota. Food Bioscience, 53 (102600). [PMID:] [10.1016/j.fbio.2023.102600]
6. Qi Yang, Huan Yu, Yiling Qu, Xiaochun Zhang, Ruocheng Xia, Ziwei Wang, Rui Tan, Lei Xiong, Shihan Xi, Jun Wu, Yuzhen Gao, Suhua Zhang, Chengtao Li. (2022) Developmental validation of the novel six-dye GoldeneyeTM DNA ID System 35InDel kit for forensic application. Forensic Sciences Research, [PMID:36817233] [10.1080/20961790.2021.1945723]
7. Xueting Guan, Yujing Feng, Yunyao Jiang, Yeye Hu, Ji Zhang, Zhengpeng Li, Chao Song, Fu Li, Jincai Hou, Ting Shen, Weicheng Hu. (2022) Simulated digestion and in vitro fermentation of a polysaccharide from lotus (Nelumbo nucifera Gaertn.) root residue by the human gut microbiota. FOOD RESEARCH INTERNATIONAL, 155 (111074). [PMID:35400452] [10.1016/j.foodres.2022.111074]
8. Jin-Guang Liu, Jia-Zheng Wan, Qing-Min Lin, Guo-Cheng Han, Xiao-Zhen Feng, Zhencheng Chen. (2021) Convenient Heme Nanorod Modified Electrode for Quercetin Sensing by Two Common Electrochemical Methods. Micromachines, 12 (12): (1519). [PMID:34945369] [10.3390/mi12121519]
9. Huaxu Zhou, Xinyu Ma, Ajabkhan Sailjoi, Yanqi Zou, Xingyu Lin, Fei Yan, Bin Su, Jiyang Liu. (2022) Vertical silica nanochannels supported by nanocarbon composite for simultaneous detection of serotonin and melatonin in biological fluids. SENSORS AND ACTUATORS B-CHEMICAL, 353 (131101). [PMID:] [10.1016/j.snb.2021.131101]
10. Jiang Bowei, Qu Weifeng, Wang Feng, Zhang Liming, Rong Haibo, Li Jienan, Wen Dan, Zeye Moutanou Modeste Judes, He Wei, Wang Chudong, Xing Hao, Zhang Tao, Jin Chuan, Chen Li, Liu Ying, Cai Jifeng, Zha Lagabaiyila. (2021) Development and validation of novel 8-dye short tandem repeat multiplex system for forensic applications. INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 135 (6): (2263-2274). [PMID:34550443] [10.1007/s00414-021-02695-9]
11. Peilin Chen, Suzhen Lei, Mingyao Tong, Qing Chang, Baodong Zheng, Yi Zhang, Hongliang Zeng. (2022) Effect of polysaccharide fractions from Fortunella margarita on the fecal microbiota of mice and SCFA production in vitro. Food Science and Human Wellness, 11 (97). [PMID:] [10.1016/j.fshw.2021.07.011]
12. Yiling Qu, RuiYang Tao, Huan Yu, Qi Yang, Ziwei Wang, Rui Tan, Xiaochun Zhang, Ruocheng Xia, Lei Xiong, Shihan Xi, Jun Wu, Yuzhen Gao, Suhua Zhang, Chengtao Li. (2021) Development and validation of a forensic six-dye multiplex assay with 29 STR loci. ELECTROPHORESIS, 42 (14-15): (1419-1430). [PMID:33864289] [10.1002/elps.202100019]
13. Xinyi Hua, Zhifang Wang, Ziqi Wang, Linlin Chen, Zaichun Zhou, Junlin Ouyang, Keqin Deng, Xiumei Yang, Haowen Huang. (2021) De Novo Development of a Universal Biosensing Platform by Rapid Direct Native Protein Modification. ANALYTICAL CHEMISTRY, 93 (12): (5291–5300). [PMID:33734672] [10.1021/acs.analchem.1c00341]
14. Guo-Cheng Han, Huifang Li, Annaleizle Ferranco, Tao Zhan, Yunyun Cheng, Zhencheng Chen, Mingyue Xue, Xiao-Zhen Feng, Heinz-Bernhard Kraatz. (2020) The construction of a simple sensor for the simultaneous detection of nitrite and thiosulfate by heme catalysis. RSC Advances, 10 (58): (35007-35016). [PMID:35515684] [10.1039/D0RA06942F]
15. Shuangshuang Wang, Feng Song, Mingkun Xie, Ke Zhang, Bowen Xie, Zhanglong Huang, Haibo Luo. (2020) Evaluation of a six-dye multiplex composed of 27 markers for forensic analysis and databasing. Molecular Genetics & Genomic Medicine, 8 (9): (e1419). [PMID:32677357] [10.1002/mgg3.1419]
16. Zhi-yong Yu, Shu-wang Duo. (2020) Facile, ultrafast synthesis of up- and down-conversion fluorescent carbon dots for highly sensitive detection of hematin. OPTICAL MATERIALS, 107 (110029). [PMID:] [10.1016/j.optmat.2020.110029]
17. Wei He, Zhenxiang Huo, Xiangying Sun, Jiangshan Shen. (2020) Facile and green synthesis of N, Cl-dual-doped carbon dots as a label-free fluorescent probe for hematin and temperature sensing. MICROCHEMICAL JOURNAL, 153 (104528). [PMID:] [10.1016/j.microc.2019.104528]
18. Tao Ruiyang, Chen Chong, Sheng Xiang, Xia Ruocheng, Zhang Xiaochun, Zhang Jingyi, Yang Zihao, Zhang Suhua, Li Chengtao. (2019) Validation of the Investigator 24plex QS Kit: A 6-dye Multiplex PCR Assay for Forensic Application in the Chinese Han Population. Forensic Sciences Research, 7 (2): (172-180). [PMID:35784410] [10.1080/20961790.2019.1665160]
19. Xie Mingkun, Song Feng, Li Jienan, Xie Bowen, Wang Shuangshuang, Wang Weizhi, Ma Hong, Luo Haibo. (2020) Validation of the AGCU Expressmarker 16 + 22Y Kit: a new multiplex for forensic application. INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 134 (1): (177-183). [PMID:31713677] [10.1007/s00414-019-02200-3]
20. Shan Chen, Congcong Yin, Tao Jiang, Mang Gao, Yun Chen, De-Yin Wu, Yanzhen Yu, Aiyang Zhang, Yimin Fang.. (2020) Triethylamine as a complexing reagent for highly efficient naked-eyes copper ions sensing – A new catalytic pathway for ultrasensitive detection. SENSORS AND ACTUATORS B-CHEMICAL, 305 (127373). [PMID:] [10.1016/j.snb.2019.127373]
21. Jiaoxing Xu, Chuxin Wu, Qiangmin Yu, Yi Zhao, Xun Li, Lunhui Guan. (2018) Ammonia Defective Etching and Nitrogen-Doping of Porous Carbon toward High Exposure of Heme-Derived Fe–Nx Site for Efficient Oxygen Reduction. ACS Sustainable Chemistry & Engineering, 6 (1): (551–560). [PMID:] [10.1021/acssuschemeng.7b02841]
22. Yuqin Wu, Hongmei Zhang, Yanqing Wang. (2017) Conformational and functional changes of bovine serum albumin induced by TiO2 nanoparticles binding. JOURNAL OF MOLECULAR LIQUIDS, 243 (358). [PMID:] [10.1016/j.molliq.2017.07.116]
23. Jienan Li, Haibo Luo, Feng Song, Lushun Zhang, Chuncao Deng, Zailiang Yu, Tianzhen Gao, Miao Liao, Yiping Hou. (2017) Validation of the Microreader™ 23sp ID system: A new STR 23-plex system for forensic application. Forensic Science International-Genetics, 27 (67). [PMID:27992828] [10.1016/j.fsigen.2016.12.005]
24. Ning Xia, Youjuan Zhang, Pengpeng Guan, Yuanqiang Hao, Lin Liu. (2015) A simple and label-free electrochemical method for detection of beta-site amyloid precursor protein cleaving enzyme and screening of its inhibitor. SENSORS AND ACTUATORS B-CHEMICAL, 213 (111). [PMID:] [10.1016/j.snb.2015.02.081]

References

1. Yuxiang Zhou, Yanyun Wang, Mengyuan Song, Lanrui Jiang, Chaoran Sun, Shuangshuang Wang, Hewen Yao, Zefei Wang, Xindi Wang, Chunhui Liu, Haibo Luo, Feng Song. (2024) A high-throughput droplet digital PCR system aiming eight DNA methylation targets for age prediction. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 240 (115943). [PMID:38181558] [10.1016/j.jpba.2023.115943]
2. Meng Shi, Demin Kong, Hui Zhang, Deming Rao, Tianlong Zhao, Jing Yang, Zhanzhi Liu, Sheng Chen, Fengshan Zhang, Jing Wu, Lei Wang. (2024) Enhancing the heterologous expression of latex clearing protein from Streptomyces sp. strain K30 in Escherichia coli through fermentation condition optimization and molecular modification. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 254 (127995). [PMID:37949282] [10.1016/j.ijbiomac.2023.127995]
3. Tao Zhan, Xiao-Zhen Feng, Yun-Yun Cheng, Guo-Cheng Han, Zhencheng Chen, Heinz-Bernhard Kraatz. (2023) Electrochemical sensor for ultrasensitive sensing of biotin based on heme conjugated with gold nanoparticles and its electrooxidation mechanism. FOOD CHEMISTRY, 429 (136997). [PMID:37516051] [10.1016/j.foodchem.2023.136997]
4. Guo-Cheng Han, Jiating Hou, Zong-Li Huang, Xiao-Zhen Feng, Zhencheng Chen, Wenxiang Xiao, Shuang Li. (2017) Electrochemical Behaviors of Ferrocene Dicarboxylate and its Application for Heme Detection. International Journal of Electrochemical Science, 12 (6245). [PMID:] [10.20964/2017.07.69]
5. Linlin Gao, Lin Zhang, Huan Liu, Jielun Hu. (2023) In vitro gastrointestinal digestion of whole grain noodles supplemented with soluble dietary fiber and their effects on children fecal microbiota. Food Bioscience, 53 (102600). [PMID:] [10.1016/j.fbio.2023.102600]
6. Qi Yang, Huan Yu, Yiling Qu, Xiaochun Zhang, Ruocheng Xia, Ziwei Wang, Rui Tan, Lei Xiong, Shihan Xi, Jun Wu, Yuzhen Gao, Suhua Zhang, Chengtao Li. (2022) Developmental validation of the novel six-dye GoldeneyeTM DNA ID System 35InDel kit for forensic application. Forensic Sciences Research, [PMID:36817233] [10.1080/20961790.2021.1945723]
7. Xueting Guan, Yujing Feng, Yunyao Jiang, Yeye Hu, Ji Zhang, Zhengpeng Li, Chao Song, Fu Li, Jincai Hou, Ting Shen, Weicheng Hu. (2022) Simulated digestion and in vitro fermentation of a polysaccharide from lotus (Nelumbo nucifera Gaertn.) root residue by the human gut microbiota. FOOD RESEARCH INTERNATIONAL, 155 (111074). [PMID:35400452] [10.1016/j.foodres.2022.111074]
8. Jin-Guang Liu, Jia-Zheng Wan, Qing-Min Lin, Guo-Cheng Han, Xiao-Zhen Feng, Zhencheng Chen. (2021) Convenient Heme Nanorod Modified Electrode for Quercetin Sensing by Two Common Electrochemical Methods. Micromachines, 12 (12): (1519). [PMID:34945369] [10.3390/mi12121519]
9. Huaxu Zhou, Xinyu Ma, Ajabkhan Sailjoi, Yanqi Zou, Xingyu Lin, Fei Yan, Bin Su, Jiyang Liu. (2022) Vertical silica nanochannels supported by nanocarbon composite for simultaneous detection of serotonin and melatonin in biological fluids. SENSORS AND ACTUATORS B-CHEMICAL, 353 (131101). [PMID:] [10.1016/j.snb.2021.131101]
10. Jiang Bowei, Qu Weifeng, Wang Feng, Zhang Liming, Rong Haibo, Li Jienan, Wen Dan, Zeye Moutanou Modeste Judes, He Wei, Wang Chudong, Xing Hao, Zhang Tao, Jin Chuan, Chen Li, Liu Ying, Cai Jifeng, Zha Lagabaiyila. (2021) Development and validation of novel 8-dye short tandem repeat multiplex system for forensic applications. INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 135 (6): (2263-2274). [PMID:34550443] [10.1007/s00414-021-02695-9]
11. Peilin Chen, Suzhen Lei, Mingyao Tong, Qing Chang, Baodong Zheng, Yi Zhang, Hongliang Zeng. (2022) Effect of polysaccharide fractions from Fortunella margarita on the fecal microbiota of mice and SCFA production in vitro. Food Science and Human Wellness, 11 (97). [PMID:] [10.1016/j.fshw.2021.07.011]
12. Yiling Qu, RuiYang Tao, Huan Yu, Qi Yang, Ziwei Wang, Rui Tan, Xiaochun Zhang, Ruocheng Xia, Lei Xiong, Shihan Xi, Jun Wu, Yuzhen Gao, Suhua Zhang, Chengtao Li. (2021) Development and validation of a forensic six-dye multiplex assay with 29 STR loci. ELECTROPHORESIS, 42 (14-15): (1419-1430). [PMID:33864289] [10.1002/elps.202100019]
13. Xinyi Hua, Zhifang Wang, Ziqi Wang, Linlin Chen, Zaichun Zhou, Junlin Ouyang, Keqin Deng, Xiumei Yang, Haowen Huang. (2021) De Novo Development of a Universal Biosensing Platform by Rapid Direct Native Protein Modification. ANALYTICAL CHEMISTRY, 93 (12): (5291–5300). [PMID:33734672] [10.1021/acs.analchem.1c00341]
14. Guo-Cheng Han, Huifang Li, Annaleizle Ferranco, Tao Zhan, Yunyun Cheng, Zhencheng Chen, Mingyue Xue, Xiao-Zhen Feng, Heinz-Bernhard Kraatz. (2020) The construction of a simple sensor for the simultaneous detection of nitrite and thiosulfate by heme catalysis. RSC Advances, 10 (58): (35007-35016). [PMID:35515684] [10.1039/D0RA06942F]
15. Shuangshuang Wang, Feng Song, Mingkun Xie, Ke Zhang, Bowen Xie, Zhanglong Huang, Haibo Luo. (2020) Evaluation of a six-dye multiplex composed of 27 markers for forensic analysis and databasing. Molecular Genetics & Genomic Medicine, 8 (9): (e1419). [PMID:32677357] [10.1002/mgg3.1419]
16. Zhi-yong Yu, Shu-wang Duo. (2020) Facile, ultrafast synthesis of up- and down-conversion fluorescent carbon dots for highly sensitive detection of hematin. OPTICAL MATERIALS, 107 (110029). [PMID:] [10.1016/j.optmat.2020.110029]
17. Wei He, Zhenxiang Huo, Xiangying Sun, Jiangshan Shen. (2020) Facile and green synthesis of N, Cl-dual-doped carbon dots as a label-free fluorescent probe for hematin and temperature sensing. MICROCHEMICAL JOURNAL, 153 (104528). [PMID:] [10.1016/j.microc.2019.104528]
18. Tao Ruiyang, Chen Chong, Sheng Xiang, Xia Ruocheng, Zhang Xiaochun, Zhang Jingyi, Yang Zihao, Zhang Suhua, Li Chengtao. (2019) Validation of the Investigator 24plex QS Kit: A 6-dye Multiplex PCR Assay for Forensic Application in the Chinese Han Population. Forensic Sciences Research, 7 (2): (172-180). [PMID:35784410] [10.1080/20961790.2019.1665160]
19. Xie Mingkun, Song Feng, Li Jienan, Xie Bowen, Wang Shuangshuang, Wang Weizhi, Ma Hong, Luo Haibo. (2020) Validation of the AGCU Expressmarker 16 + 22Y Kit: a new multiplex for forensic application. INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 134 (1): (177-183). [PMID:31713677] [10.1007/s00414-019-02200-3]
20. Shan Chen, Congcong Yin, Tao Jiang, Mang Gao, Yun Chen, De-Yin Wu, Yanzhen Yu, Aiyang Zhang, Yimin Fang.. (2020) Triethylamine as a complexing reagent for highly efficient naked-eyes copper ions sensing – A new catalytic pathway for ultrasensitive detection. SENSORS AND ACTUATORS B-CHEMICAL, 305 (127373). [PMID:] [10.1016/j.snb.2019.127373]
21. Jiaoxing Xu, Chuxin Wu, Qiangmin Yu, Yi Zhao, Xun Li, Lunhui Guan. (2018) Ammonia Defective Etching and Nitrogen-Doping of Porous Carbon toward High Exposure of Heme-Derived Fe–Nx Site for Efficient Oxygen Reduction. ACS Sustainable Chemistry & Engineering, 6 (1): (551–560). [PMID:] [10.1021/acssuschemeng.7b02841]
22. Yuqin Wu, Hongmei Zhang, Yanqing Wang. (2017) Conformational and functional changes of bovine serum albumin induced by TiO2 nanoparticles binding. JOURNAL OF MOLECULAR LIQUIDS, 243 (358). [PMID:] [10.1016/j.molliq.2017.07.116]
23. Jienan Li, Haibo Luo, Feng Song, Lushun Zhang, Chuncao Deng, Zailiang Yu, Tianzhen Gao, Miao Liao, Yiping Hou. (2017) Validation of the Microreader™ 23sp ID system: A new STR 23-plex system for forensic application. Forensic Science International-Genetics, 27 (67). [PMID:27992828] [10.1016/j.fsigen.2016.12.005]
24. Ning Xia, Youjuan Zhang, Pengpeng Guan, Yuanqiang Hao, Lin Liu. (2015) A simple and label-free electrochemical method for detection of beta-site amyloid precursor protein cleaving enzyme and screening of its inhibitor. SENSORS AND ACTUATORS B-CHEMICAL, 213 (111). [PMID:] [10.1016/j.snb.2015.02.081]

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