HEPES - ≥99.5%(T), high purity , CAS No.7365-45-9

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  • ≥99.5%(T)
Item Number
H109407
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Multipurpose HEPES buffer; used in cell culture

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Biological buffer

Basic Description

SynonymsHEPES | 7365-45-9 | 2-(4-(2-Hydroxyethyl)piperazin-1-yl)ethanesulfonic acid | 4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid | 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid | 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)- | 4-(2-HYDROXYETHYL)-1-PI
Specifications & Purity≥99.5%(T)
Biochemical and Physiological MechanismsMulti purpose HEPES buffer used in cell culture and other biological research. Working pH range in aqueous solution: 6.8 - 8.2. Does not form complexes with metal ions. Used in cell culture media.
Storage TempArgon charged
Shipped InNormal
Product Description

HEPES has been described as one of the best all-purpose buffers available for biological research. At biological pH, the molecule is zwitterionic, and is effective as a buffer at pH 6.8 to 8.2. HEPES has been used in a wide variety of applications, including tissue culture. It is commonly used to buffer cell culture media in air. HEPES finds its usage in in vitro experiments on Mg. HEPES, also known as 4-(2-Hydroxyethyl)piperazine-1-ethane-sulfonic acid, is a zwitterionic N-substituted aminosulfonic acid buffer. It is effective in the pH 6.8-8.2 range, with a pKa of 7.48 at 25°C. Recognized as one of the best all-purpose buffers, especially in cell biology, biochemical, and biological research, HEPES is a dipolar ionic buffer and one of the Good′s buffers that does not form significant complexes with most metal ions. This property makes it suitable as a non-coordinating buffer in solutions with metal ions. Widely utilized in cell culture, HEPES excels at maintaining physiological pH despite fluctuations in carbon dioxide concentration produced by cellular respiration, a feature not as prominent in bicarbonate buffers. It serves as an ampholytic separator for creating pH gradients in isoelectric focusing and exhibits less interference with DNA-restriction enzyme reactions compared to buffers with fewer substituted amine groups, such as Tris. Beyond these applications, HEPES may find application in various biological and biochemical studies, including immunoprecipitation, cell lysis, and live cell imaging. Its versatility makes it an indispensable tool in diverse research applications.

Associated Targets(non-human)

SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
INCHI InChI=1S/C8H18N2O4S/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14/h11H,1-8H2,(H,12,13,14)
InChi Key JKMHFZQWWAIEOD-UHFFFAOYSA-N
Canonical SMILES C1CN(CCN1CCO)CCS(=O)(=O)O
Isomeric SMILES C1CN(CCN1CCO)CCS(=O)(=O)O
RTECS TL6809000
PubChem CID 23831
Molecular Weight 238.30
Reaxy-Rn 883043

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Chemical and Physical Properties

SolubilitySolvent:water, Max Conc. mg/mL: 238.3, Max Conc. mM: 1000
SensitivityMoisture sensitive.
Melt Point(°C)210 °C

Safety and Hazards(GHS)

RTECS TL6809000
Reaxy-Rn 883043
Merck Index 4654

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56. Wei Jiang, Xiaoyuan Wang, YunJiao Ma, Ming Du, Chao Wu, Xianbing Xu.  (2023)  Mechanism of Carbon Skeleton Formation of 2,3,5-Trimethylpyrazine via a Conversion Reaction between Methylglyoxal and Glyoxal.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  71  (13): (5337–5344).  [PMID:36942552]
57. Shaoyin Wei, Sijie Zhou, Wenjuan Huang, Xingjie Zan, Wujun Geng.  (2023)  Efficient Delivery of Antibodies Intracellularly by Co-Assembly with Hexahistidine-Metal Assemblies (HmA).  International Journal of Nanomedicine,      [PMID:34785893]
58. Wenxia Tian, Xiaofang Liu, Jia Zheng, Yi Ma, Huibo Luo, Xiaogang Luo, Changjun Hou, Danqun Huo.  (2023)  Array-based sensing and discrimination of segmented Baijiu using organic molecules-regulated PEI@Ag NPs@Ln as fluorescent probes.  FOOD CHEMISTRY,  417  (135888).  [PMID:36917907]
59. Xue Xia, Tong Zhou, Han Zhang, Heping Cui, Foxin Zhang, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2023)  Simultaneously Enhanced Formation of Pyrazines and Furans during Thermal Degradation of the Glycyl-l-glutamine Amadori Compound by Selected Exogenous Amino Acids and Appropriate Elevated Temperatures.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  71  (10): (4346–4357).  [PMID:36880130]
60. Lanjie Lei, Chengtao Xu, Xing Dong, Biao Ma, Yichen Chen, Qing Hao, Chao Zhao, Hong Liu.  (2023)  Continuous Glucose Monitoring in Hypoxic Environments Based on Water Splitting-Assisted Electrocatalysis.  Chemosensors,  11  (2): (149).  [PMID:]
61. Kanglin Pei, Di Li, Wenjing Qi, Di Wu.  (2023)  Ultrarapid Microwave-Assisted Synthesis of Fluorescent Silver Coordination Polymer Nanoparticles and Its Application in Detecting Alkaline Phosphatase Activity.  MOLECULES,  28  (4): (1892).  [PMID:36838879]
62. Ying Tang, Yanwen Liu, Jinmiao Wang, Juan Wang, Zhihong Liu.  (2023)  In Vivo Tracking of Persistent Organic Pollutants via a Coaxially Integrated and Implanted Photofuel Microsensor.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,  57  (7): (2826–2836).  [PMID:36775915]
63. Yi-Xuan Li, Junji Li, Hai-Bo Zeng, Xue-Ji Zhang, Serge Cosnier, Dan Shan.  (2023)  Artificial Light-Harvesting System Based on Zinc Porphyrin and Benzimidazole: Construction, Resonance Energy Transfer, and Amplification Strategy for Electrochemiluminescence.  ANALYTICAL CHEMISTRY,  95  (6): (3493–3498).  [PMID:36734630]
64. Yulin Wang, Libo Nie, Yongbiao Hua, Liang Gong, Xiuzhen Qiu, Huishi Guo.  (2023)  A simple paper-based nickel nanocluster-europium mixed ratio fluorescent probe for rapid visual sensing of tetracyclines.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  292  (122431).  [PMID:36753865]
65. Lixia Lu, Xinyu Shao, Jianwen Gao, Bingchan Song, Linhe Ding, Jianhua Zhou.  (2023)  Surface plasmon field enhanced upconversion luminescence for the screening and detection of phenolic environmental estrogens.  FOOD CHEMISTRY,  413  (135606).  [PMID:36773364]
66. Huahui Gao, Xinmei Song, Qirong Chen, Ruo Yuan, Yun Xiang.  (2023)  Target-promoted specific activation of m6A-DNAzyme for SPEXPAR-amplified and highly sensitive non-label electrochemical assay of FTO demethylase.  ANALYTICA CHIMICA ACTA,  1247  (340902).  [PMID:36781254]
67. Jingwen Zhu, Xue Xia, Foxin Zhang, Shiqing Song, Heping Cui, Khizar Hayat, Qiang Zhang, Xiaoming Zhang, Chi-Tang Ho.  (2023)  Taste characteristic and the mechanism of light-colored Maillard reaction products derived from gluten hydrolysate.  Food Bioscience,  52  (102394).  [PMID:]
68. Chunxu Chen, Tianhui Li, Guijie Chen, Dan Chen, Yujia Peng, Bing Hu, Yi Sun, Xiaoxiong Zeng.  (2023)  Prebiotic effect of sialylated immunoglobulin G on gut microbiota of patients with inflammatory bowel disease by in vitro fermentation.  Food Bioscience,  52  (102393).  [PMID:]
69. Chunyan Wang, Yaxing Zhang, Chang Liu, Siyu Gou, Shanjin Hu, Weiwei Guo.  (2023)  A portable colorimetric point-of-care testing platform for MicroRNA detection based on programmable entropy-driven dynamic DNA network modulated DNA-gold nanoparticle hybrid hydrogel film.  BIOSENSORS & BIOELECTRONICS,  225  (115073).  [PMID:36701948]
70. Hanyun Jiang, Yanping Wang, Xiankang Xu, Leiyu Deng, Lifang Feng, Jianzhong Han, Weilin Liu.  (2023)  Effect of oligosaccharides as lyoprotectants on the stability of curcumin-loaded nanoliposomes during lyophilization.  FOOD CHEMISTRY,  410  (135436).  [PMID:36640657]
71. Zhaowei Zhang, Xuehui Liu, Xiaoqing Yang, Ying Jiang, Ang Li, Jiying Cong, Yuwei Li, Qinjian Xie, Chen Xu, Dingbin Liu.  (2023)  Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer.  Journal of Extracellular Vesicles,  12  (1): (12300).  [PMID:36604402]
72. Xiao Li Li, Peng Liu, Bin Chu, Jin Mei He, Zhen Wang, Song Wang, Chang Sheng Chen, Xiao Hong Ge, Hui Li, Wei Qiang Liu.  (2023)  Myocardial injection of thermosensitive HADOPA/Ca-FVI/Alg hydrogels improves cardiac repair after myocardial infarction.  REACTIVE & FUNCTIONAL POLYMERS,  183  (105492).  [PMID:]
73. Ruan Shuangrong, Yin Weimin, Chang Jiao, Yang Yan, Sun Jiuyuan, Ma Xiaoyi, Liu Ying, Zang Jie, Liu Yiqiong, Li Yongyong, Ren Tianbin, Dong Haiqing.  (2022)  Acidic and hypoxic tumor microenvironment regulation by CaO2-loaded polydopamine nanoparticles.  JOURNAL OF NANOBIOTECHNOLOGY,  20  (1): (1-14).  [PMID:36577992]
74. Jingxin Liu, Chenchen Ge, Ling Zha, Ligen Lin, Rongsong Li.  (2023)  Simple Nano-Luciferase-Based Assay for the Rapid and High-Throughput Detection of SARS-CoV-2 3C-Like Protease.  ANALYTICAL CHEMISTRY,  95  (2): (714–719).  [PMID:36576396]
75. Shujin Wang, Ziting Liu, Li Wang, Jianing Xu, Ru Mo, Yue Jiang, Cuie Wen, Zhihui Zhang, Luquan Ren.  (2023)  Superhydrophobic Mechano-Bactericidal Surface with Photodynamic Antibacterial Capability.  ACS Applied Materials & Interfaces,  15  (1): (723–735).  [PMID:36573916]
76. Zhenzhen Jia, Wei Wei, Kangsheng Tu, Biyun Fang, Mingzhen Zhang, Lingling Shi.  (2023)  Point-of-care monitoring of dry eye disease using lysozyme in tear based on commercial pregnancy test strips.  SENSORS AND ACTUATORS B-CHEMICAL,  378  (133179).  [PMID:]
77. Jing Yuan, Hong Duan, Lei Wang, Siyuan Wang, Yanbin Li, Jianhan Lin.  (2023)  A three-in-one hybrid nanozyme for sensitive colorimetric biosensing of pathogens.  FOOD CHEMISTRY,  408  (135212).  [PMID:36535179]
78. Wang Li, Cui Baocheng, Qiu Keyuan, Huang Jiao, Liang Changhai.  (2022)  Modification of nitrile hydratase from Rhodococcus erythropolis CCM2595 by semirational design to enhance its substrate affinity.  Biointerphases,  17  (6):   [PMID:36456206]
79. Guolong Huang, Yifan Qiu, Lei Bi, Huiyi Wei, Guocong Li, Zhijun Li, Peizhen Ye, Min Yang, Yanfang Shen, Hao Liu, Lu Wang, Hongjun Jin.  (2022)  PET Imaging of P2X7 Receptor (P2X7R) for Neuroinflammation with Improved Radiosynthesis of Tracer [18F]4A in Mice and Non-human Primates.  ACS Chemical Neuroscience,  13  (23): (3464–3476).  [PMID:36441909]
80. Yi He, Xiangjian Liao, Haonan Wu, Jialiang Huang, Yi Zhang, Yanyu Peng, Zhen Wang, Xin Cao, Caijun Wu, Xiaojun Luo.  (2023)  A controllable SERS biosensor for ultrasensitive detection of miRNAs based on porous MOFs and subject-object recognition ability.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  289  (122134).  [PMID:36512966]
81. Xue Xia, Yun Zhai, Heping Cui, Han Zhang, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Glycine, Diglycine, and Triglycine Exhibit Different Reactivities in the Formation and Degradation of Amadori Compounds.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (47): (14907–14918).  [PMID:36378039]
82. Meirong Huo, Jiyuan Zhou, Honglan Wang, Yuzhao Zheng, Yuqing Tong, Jianping Zhou, Jiyong Liu, Tingjie Yin.  (2022)  A pHe sensitive nanodrug for collaborative penetration and inhibition of metastatic tumors.  JOURNAL OF CONTROLLED RELEASE,  352  (893).  [PMID:36370879]
83. Dan Li, Danyang Wang, Ye He, Bailong Tao, Xiaoxia Liu, Yulu Yang, Lu Tan, Yuchen Zhang, Jingwei Hu, Weihu Yang, Yu Tang, Kaiyong Cai.  (2023)  A HAase/NIR responsive surface on titanium implants for treating bacterial infection and improving osseointegration.  JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,  143  (93).  [PMID:]
84. Cheng Qiaojuan, Chi Xinyu, Liang Yingchao, Li Wanxin, Sun Jiaxin, Tao Jin, Wang Zhi.  (2023)  Immobilization of Lipase in Cu-BTC MOF with Enhanced Catalytic Performance for Resolution of N-hydroxymethyl Vince Lactam.  APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,  195  (2): (1216-1230).  [PMID:36342624]
85. Xuwen Gao, Xiancheng Liu, Ying Zeng, Qingqing Zhang, Bin Zhang, Guizheng Zou.  (2022)  Spectrum-Resolved Electrochemiluminescence to Multiplex the Immunoassay and DNA Probe Assay.  ANALYTICAL CHEMISTRY,  94  (45): (15801–15808).  [PMID:36334096]
86. Shen Yunfu, Guo Kaiqiang, Ma Aijun, Huang Zhe, Du Jingjing, Chen Junhe, Lin Qianyu, Wei Chengming, Wang Zi, Zhang Fuming, Zhang Juan, Lin Wanjun, Feng Na, Ma Wenzhe.  (2022)  Mitochondrial toxicity evaluation of traditional Chinese medicine injections with a dual in vitro approach.  Frontiers in Pharmacology,  13    [PMID:36408232]
87. Li Gang, Wu Ming-Huo, Liu Yan, Hu Yu-Feng.  (2023)  Facile fluorescent probe for simultaneous fluorescence detection of fluoroquinolones and copper.  CHEMICAL PAPERS,  77  (3): (1423-1432).  [PMID:]
88. Xiaoqing Xiong, Ye Yuan, Gengwen Chen, Miao Li, Lihua Lyu, Hongjuan Zhao, Jun Yan, Yulan Qian, Junyang Zhu, Chengqi Jiao.  (2023)  Construction, photophysical properties, structure-activity relationship, and applications of fluorescein analogs.  DYES AND PIGMENTS,  208  (110870).  [PMID:]
89. Min Chen, Jun Wang, Qianbo Zhang, Jinsheng Zhang, Zhiming Chen, Rongguo Sun.  (2023)  Reversible detection of Hg(II) in pure water based on thymine modified nitrogen, sulfur co-doped carbon dots combined with antidote.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  286  (121998).  [PMID:36279800]
90. Jianmei Yang, Qian Bi, Xinmei Song, Ruo Yuan, Yun Xiang.  (2023)  Aptamer/organometallic receptor-based and label-free sensitive electrochemical detection of amino acid via multi-pedal DNA walker/DNAzyme amplifications.  SENSORS AND ACTUATORS B-CHEMICAL,  375  (132876).  [PMID:]
91. Zhaoshen Li, Xiaochun Deng, Xiaoping Hong, Shengfa Zhao.  (2022)  Nanozyme Based on Dispersion of Hemin by Graphene Quantum Dots for Colorimetric Detection of Glutathione.  MOLECULES,  27  (20): (6779).  [PMID:36296372]
92. Yi-Xuan Li, Jing Li, Dunru Zhu, Ju-Zheng Wang, Guo-Fang Shu, Junji Li, Sheng-Li Zhang, Xue-Ji Zhang, Serge Cosnier, Hai-Bo Zeng, Dan Shan.  (2022)  2D Zn-Porphyrin-Based Co(II)-MOF with 2-Methylimidazole Sitting Axially on the Paddle–Wheel Units: An Efficient Electrochemiluminescence Bioassay for SARS-CoV-2.  ADVANCED FUNCTIONAL MATERIALS,  32  (48): (2209743).  [PMID:36247688]
93. Bojiao Tang, Xiaoling Xie, Ruhui Yang, Sijie Zhou, Ronggui Hu, Jiayao Feng, Qinxiang Zheng, Xingjie Zan.  (2022)  Decorating hexahistidine-metal assemblies with tyrosine enhances the ability of proteins to pass through corneal biobarriers.  Acta Biomaterialia,  153  (231).  [PMID:36126912]
94. Lunjie Huang, Da-Wen Sun, Hongbin Pu, Cuiyun Zhang, Daorui Zhang.  (2023)  Nanocellulose-based polymeric nanozyme as bioinspired spray coating for fruit preservation.  FOOD HYDROCOLLOIDS,  135  (108138).  [PMID:]
95. X. Cui, Y. Zhou, Y. Zheng, L. Cao, L. Gao, J. Duan, H. Yin, S. Ai.  (2022)  Investigation of the enhanced photoactivity of CdS/Bi2MoO6/MoSe2 and its application in antibody-free enzyme-assisted photoelectrochemical strategy for detection of N6-methyladenosine and FTO protein.  Materials Today Nano,  20  (100269).  [PMID:]
96. Jie Xiang, Junyi Zhang, Shunmei Li, Ruo Yuan, Yun Xiang.  (2022)  Aptamer-based and sensitive label-free colorimetric sensing of phenylalanine via cascaded signal amplifications.  ANALYTICA CHIMICA ACTA,  1230  (340393).  [PMID:36192064]
97. Mingyu You, Lei Zhang, Tobias A. Gmür, Kaihuan Zhang, Stefan Zürcher, Wen Li, Guangyin Yuan, Nicholas D. Spencer, Jia Pei.  (2022)  Impact of graft architecture of PEGylated copolymers assembly on hydroxyapatite in the differential regulation of initial cell and bacterial adhesion.  APPLIED SURFACE SCIENCE,  606  (154836).  [PMID:]
98. Ding Wen, Miao Qingzhen, Bao Xiuli, Wang Shiyuan, Lu Jing, Lyu Mingsheng, Wang Shujun.  (2022)  On-site detection of fish furunculosis by combining DNAzyme and carboxyl-functionalized graphene.  Frontiers in Chemistry,  10    [PMID:36405323]
99. Yujing Kong, Fang Yuan, Fei Yang, Cuiling Zhang, Yuezhong Xian.  (2022)  Cell-Membrane-Anchored Upconversion Nanoprobe for Near-Infrared Light Triggered Cell–Cell Interactions.  ANALYTICAL CHEMISTRY,  94  (35): (12024–12032).  [PMID:35994569]
100. Li Fu, Xiancheng Liu, Ying Zeng, Qingqing Zhang, Bin Zhang, Xuwen Gao, Guizheng Zou.  (2022)  Coreactant-free and Near-Infrared Electrochemiluminescence Immunoassay with n-Type Au Nanocrystals as Luminophores.  ANALYTICAL CHEMISTRY,  94  (34): (11934–11939).  [PMID:35976331]
101. Miaomiao Zhou, Jiyu Feng, Yuancai Chen, Yongyou Hu, Song Song.  (2022)  Towards BioMnOx-mediated intra/extracellular electron shuttling for doxycycline hydrochloride metabolism in Bacillus thuringiensis.  JOURNAL OF ENVIRONMENTAL MANAGEMENT,  320  (115891).  [PMID:36056494]
102. Piaotong Liu, Rusi Hao, Wenliang Sun, Ziyi Lin, Tianfeng Jing.  (2022)  One-pot synthesis of copper nanocluster/Tb-MOF composites for the ratiometric fluorescence detection of Cu2+.  LUMINESCENCE,  37  (10): (1793-1799).  [PMID:35946061]
103. Qian Zhao, Jing Wang.  (2022)  A sensitive fluorescent sensor based on terpyridine@Zn2+-modified mesoporous silica for the detection of sulfonamide antibiotics.  Materials Advances,  (20): (7569-7578).  [PMID:]
104. Lei Jiang, Yaning Han, Youxun Li, Zhuang Li, Shuyuan Zhang, Xiudong Zhu, Zhibin Liu, Yuxue Chen, Susana Fernandez-Garcia, Yongjiao Tang, Xiaowei Chen.  (2022)  Split-type assay for wide-range sensitive sensing of ochratoxin A with praseodymia nanorods.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,  652  (129804).  [PMID:]
105. Baoxia Liu, Yaoyao Zhang, Yuanqiang Hao, Xu Zhu, Yintang Zhang, Yanli Zhou, Hongliang Tan, Maotian Xu.  (2022)  All-in-One Luminescent Lanthanide Coordination Polymer Nanoprobe for Facile Detection of Protein Kinase Activity.  ANALYTICAL CHEMISTRY,  94  (30): (10730–10736).  [PMID:35853147]
106. Sameer Hussain, Xi Chen, Chaofeng Wang, Yi Hao, Xuemeng Tian, Yulian He, Jing Li, M. Shahid, Parameswar Krishnan Iyer, Ruixia Gao.  (2022)  Aggregation and Binding-Directed FRET Modulation of Conjugated Polymer Materials for Selective and Point-of-Care Monitoring of Serum Albumins.  ANALYTICAL CHEMISTRY,  94  (30): (10685–10694).  [PMID:35849826]
107. Liu Piaotong, Hao Rusi, Sun Wenliang, Lin Ziyi, Jing Tianfeng, Yang Haizhen.  (2022)  A “bottle-around-ship” method to encapsulated carbon nitride and CdTe quantum dots in ZIF-8 as the dual emission fluorescent probe for detection of mercury (II) ion.  ANALYTICAL SCIENCES,  38  (10): (1305-1312).  [PMID:35838911]
108. XueQin Li, Xingcen Liu, Yujie Liu, Ran Gao, Xia Wu, Xibao Gao.  (2022)  Highly sensitive detection of dopamine based on gold nanoflowers enhanced-Tb(III) fluorescence.  TALANTA,  249  (123700).  [PMID:35751922]
109. Zhi Li, Shuhua Han.  (2022)  A Chemosensor of 1,8-Dihydroxyanthraquinone PMOs Prepared in a Ternary Deep Eutectic Solvent for the Sensitive Detection of Cu2+.  ACS Omega,  (26): (22613–22625).  [PMID:35811913]
110. Xiaoyan Gan, Feng Qiu, Ruo Yuan, Yun Xiang.  (2022)  Biobarcode and sequence-responsive DNA nanocapsules for label-free and sensitive electrochemical detection of circulating tumor cells.  SENSORS AND ACTUATORS B-CHEMICAL,  368  (132207).  [PMID:]
111. Yinping Zhao, Yawei Kong, Liwen Chen, Han Sheng, Yiyan Fei, Lan Mi, Bei Li, Jiong Ma.  (2022)  Application of Dual-Enhanced Surface-Enhanced Raman Scattering Probe Technology in the Diagnosis of Tumor Cells in Vitro.  MOLECULES,  27  (11): (3582).  [PMID:35684522]
112. Yuting Li, Luhan Wang, Minhua Qian, Shengda Qi, Lei Zhou, Qiaosheng Pu.  (2022)  Concise analysis of γ-hydroxybutyric acid in beverages and urine by capillary electrophoresis with capacitively coupled contactless conductivity detection using 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid as background electrolyte.  JOURNAL OF CHROMATOGRAPHY A,  1675  (463191).  [PMID:35675730]
113. Yexuan Mao, Meng Dang, Jianwei Zhang, Xianqing Huang, Mingwu Qiao, Lianjun Song, Qiuyan Zhao, Mingyue Ding, Youyi Wang, Zizhe Li, Ke Song, Qingge Shi, Xiya Zhang.  (2022)  Peptide amphiphile inspired self-assembled, ordered gold nanocomposites for improved sensitivity of electrochemical immunosensor: Applications in determining the total aflatoxin amount in food stuffs.  TALANTA,  247  (123532).  [PMID:35609486]
114. Xue Xia, Yun Zhai, Heping Cui, Han Zhang, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Structural diversity and concentration dependence of pyrazine formation: Exogenous amino substrates and reaction parameters during thermal processing of l-alanyl-l-glutamine Amadori compound.  FOOD CHEMISTRY,  390  (133144).  [PMID:35594769]
115. Yu Wang, Shuang Zeng, Hongyan Cui, Haidong Li, Zhen Li, Jingyun Wang, Qixian Chen.  (2022)  Reversible Chemical Protein Modification to Endogenous Glutathione and Its Utilities in the Manufacture of Transcellular Pro-Enzymes.  BIOMACROMOLECULES,  23  (5): (2138–2149).  [PMID:35471918]
116. Yu Liu, Yanan Cao, Cong Zhang, Cheng Ye, Qinglai Bian, Xue Cheng, Hui Xia, Junping Zheng, Hongtao Liu.  (2022)  A novel colorimetric method for H2O2 sensing and its application: Fe2+-catalyzed H2O2 prevents aggregation of AuNPs by oxidizing cysteine (FeHOAuC).  ANALYTICA CHIMICA ACTA,  1207  (339840).  [PMID:35491046]
117. Xinran Xu, Ping-Ping He, Xiaoxue Du, Weiwei Guo.  (2022)  Reversible and Remote Thermoregulation of a Recyclable DNAzyme/pNIPAM Microgel Catalyst Formed via a Microfluidic Device.  Advanced Sustainable Systems,  (6): (2100265).  [PMID:]
118. Ziqiang Zhou, Hongzhi Hu, Ling Xia, Gongke Li, Xiaohua Xiao.  (2022)  A bisspiropyran fluorescent probe for the selective and rapid detection of cyanide anion in liqueurs.  NEW JOURNAL OF CHEMISTRY,  46  (17): (7992-7998).  [PMID:]
119. Amjad Hussain Memon, Bin Wei, Saira Shams, Yucui Jiang, Mengzhao Jiao, Mingming Su, Hao Liang.  (2022)  Construction of robust bienzyme-mimicking nanocatalysts for dye degradation by self-assembly of hematin, metal ions, and nucleotides.  Catalysis Science & Technology,  12  (9): (2846-2855).  [PMID:]
120. Yan Yang, Guoliang Li, Panxue Wang, Lihua Fan, Yiheng Shi.  (2022)  Highly sensitive multiplex detection of foodborne pathogens using a SERS immunosensor combined with novel covalent organic frameworks based biologic interference-free Raman tags.  TALANTA,  243  (123369).  [PMID:35278771]
121. Fan Leng, Sai Lei, Bin Luo, Siyao Lv, Long Huang, Xulin Jiang.  (2022)  Size-tunable and biodegradable thrombin-functionalized carboxymethyl chitin microspheres for endovascular embolization.  CARBOHYDRATE POLYMERS,  286  (119274).  [PMID:35337526]
122. Xuwen Gao, Huimin Zhao, Dongyang Wang, Yuqi Xu, Bin Zhang, Guizheng Zou.  (2022)  Selectively Lighting Up Singlet Oxygen via Aggregation-Induced Electrochemiluminescence Energy Transfer.  ANALYTICAL CHEMISTRY,  94  (8): (3718–3726).  [PMID:35166109]
123. Ziyan Wang, Heping Cui, Mengyu Ma, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Controlled Formation of Pyrazines: Inhibition by Ellagic Acid Interaction with N-(1-Deoxy-d-xylulos-1-yl)-glycine and Promotion through Ellagic Acid Oxidation.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (5): (1618–1628).  [PMID:35089027]
124. Huixue Wang, Jinya Liu, Wei Chen, Jintong Na, Yong Huang, Guiyin Li.  (2022)  A fluorescence aptasensor based on GSH@GQDs and RGO for the detection of Glypican-3.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  270  (120798).  [PMID:35051745]
125. Yue Sun, Yingpeng Gu, Xiao Li, Rajendra Prasad Singh.  (2022)  Synthesis of novel thiol-modified lysozyme coated magnetic nanoparticles for the high selective adsorption of Hg(II).  REACTIVE & FUNCTIONAL POLYMERS,  170  (105129).  [PMID:]
126. Hui Jiang, Shi-Jun Yin, Xu Wang, Min Lu, Hao Zhang, Feng-Qing Yang.  (2022)  Preparation of covalently bonded liposome capillary column and its application in evaluation of drug membrane permeability.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  209  (114513).  [PMID:34883420]
127. Ying Yang, Chaofeng Wang, Qin Shu, Na Xu, Shuangqing Qi, Shujuan Zhuo, Changqing Zhu, Jinyan Du.  (2022)  Facile one-step fabrication of Cu-doped carbon dots as a dual-selective biosensor for detection of pyrophosphate ions and measurement of pH.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  268  (120681).  [PMID:34894564]
128. Yue Huang, Jiehua Ma, Yuting Yan, Chao Li.  (2022)  Metal-bridged DNA-functionalized silica nanoparticles for multifacet biological applications.  MICROCHEMICAL JOURNAL,  173  (107017).  [PMID:]
129. Shuangqin Li, Di Liu, Bingyan Wu, Huipeng Sun, Xiaoyan Liu, Haixia Zhang, Nana Ding, Lan Wu.  (2022)  One-pot synthesis of a peroxidase-like nanozyme and its application in visual assay for tyrosinase activity.  TALANTA,  239  (123088).  [PMID:34838324]
130. Shuai Chen, Yong Yan, Yue Yu, Zhenfeng Wang, Xiaojun Zhu, Liping Sun, Chao Li, Feng Wang.  (2021)  Ferric Ions as a Catalytic Mediator in Metal-EGCG Network for Bactericidal Effect and Pathogenic Biofilm Eradication at Physiological pH.  Advanced Materials Interfaces,  (23): (2101605).  [PMID:]
131. Mengjiao Mo, Xueshen Wang, Lingyue Ye, Yaoquan Su, Yang Zhong, Lingzhi Zhao, Yunyun Zhou, Juanjuan Peng.  (2022)  A simple paper-based ratiometric luminescent sensor for tetracyclines using copper nanocluster-europium hybrid nanoprobes.  ANALYTICA CHIMICA ACTA,  1190  (339257).  [PMID:34857135]
132. Fang Yuan, Yujing Kong, Jia You, Cuiling Zhang, Yuezhong Xian.  (2021)  Rational Synthesis of Imine-Linked Fluorescent Covalent Organic Frameworks with Different pKa for pH Sensing In Vitro and In Vivo.  ACS Applied Materials & Interfaces,  13  (43): (51351–51361).  [PMID:34689554]
133. Yi Zhang, Jie Zhou, Xiao-Xiao Zhang, Wen-Long Wang, Cheng Yang, Xueli Shi, Yong-Wei Feng, Renagul Abdurahman.  (2022)  NIR persistent luminescence nanoparticles based turn-on aptasensor for autofluorescence-free determination of 17β-estradiol in milk.  FOOD CHEMISTRY,  373  (131432).  [PMID:34717086]
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91. Zhaoshen Li, Xiaochun Deng, Xiaoping Hong, Shengfa Zhao.  (2022)  Nanozyme Based on Dispersion of Hemin by Graphene Quantum Dots for Colorimetric Detection of Glutathione.  MOLECULES,  27  (20): (6779).  [PMID:36296372]
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Solution Calculators