Grouped product items

SKU

Size

Availability

Price

Qty

H126784-5mg

5mg

Available within 4-8 weeks(?)

$64.90

H126784-25mg

25mg

Available within 4-8 weeks(?)

$292.90

H126784-100mg

100mg

Available within 4-8 weeks(?)

$489.90

Basic Description

Synonyms	hesperadin\|422513-13-1\|hesperadine\|UNII-PTR491OS14\|CHEBI:70726\|TCMDC-135395\|CHEMBL514409\|PTR491OS14\|(Z)-N-(2-oxo-3-(phenyl((4-(piperidin-1-ylmethyl)phenyl)amino)methylene)indolin-5-yl)ethanesulfonamide\|N-[(3Z)-2-oxo-3-[phenyl-[4-(piperidin-1-ylmethyl)anil
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	esperadin prevents the phosphorylation of recombinant trypanosome histone H3 by the T. brucei Aurora kinase-1 (TbAUK1) from pathogenic Trypanosoma brucei with IC50 of 40 nM in vitro kinase assays. Hesperadin significantly inhibits cell growth of cultured
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of aurora kinase B
Product Description	Hesperadin potently inhibits Aurora B with IC50 of 250 nM in a cell-free assay. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo.

Associated Targets

CXCL14 Tbio C-X-C motif chemokine 14 0 Activities

Discover Target: CXCL14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ERBB4 Tclin Receptor tyrosine-protein kinase erbB-4 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EPHA1 Tchem Ephrin type-A receptor 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK16 Tchem Cyclin-dependent kinase 16 0 Activities

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CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK5 Tchem Cyclin-dependent-like kinase 5 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SRC Tclin Proto-oncogene tyrosine-protein kinase Src 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT4 Tclin Vascular endothelial growth factor receptor 3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

YES1 Tclin Tyrosine-protein kinase Yes 0 Activities

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TYK2 Tclin Non-receptor tyrosine-protein kinase TYK2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 0 Activities

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FGFR1 Tclin Fibroblast growth factor receptor 1 0 Activities

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FGFR2 Tclin Fibroblast growth factor receptor 2 0 Activities

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FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MET Tclin Hepatocyte growth factor receptor 0 Activities

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IGF1R Tclin Insulin-like growth factor 1 receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MERTK Tchem Tyrosine-protein kinase Mer 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SIK2 Tchem Serine/threonine-protein kinase SIK2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLK4 Tchem Serine/threonine-protein kinase PLK4 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIM1 Tchem Serine/threonine-protein kinase pim-1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDGFRA Tclin Platelet-derived growth factor receptor alpha 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIM2 Tchem Serine/threonine-protein kinase pim-2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP4K5 Tchem Mitogen-activated protein kinase kinase kinase kinase 5 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BTK Tclin Tyrosine-protein kinase BTK 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKB Tchem Aurora kinase B 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKC Tchem Aurora kinase C 0 Activities

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FLT1 Tclin Vascular endothelial growth factor receptor 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AAK1 Tchem AP2-associated protein kinase 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

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ACVRL1 Tchem Serine/threonine-protein kinase receptor R3 0 Activities

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AKT3 Tchem RAC-gamma serine/threonine-protein kinase 0 Activities

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AKT2 Tchem RAC-beta serine/threonine-protein kinase 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKT1 Tchem RAC-alpha serine/threonine-protein kinase 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLK3 Tchem Dual specificity protein kinase CLK3 0 Activities

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CLK1 Tchem Dual specificity protein kinase CLK1 0 Activities

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CLK2 Tchem Dual specificity protein kinase CLK2 0 Activities

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CLK4 Tchem Dual specificity protein kinase CLK4 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3A Tclin Glycogen synthase kinase-3 alpha 0 Activities

Discover Target: GSK3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC2A1 Tchem Solute carrier family 2, facilitated glucose transporter member 1 0 Activities

Discover Target: SLC2A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KIT Tclin Mast/stem cell growth factor receptor Kit 0 Activities

Discover Target: KIT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NTRK1 Tclin High affinity nerve growth factor receptor 0 Activities

Discover Target: NTRK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK2 Tclin Tyrosine-protein kinase JAK2 0 Activities

Discover Target: JAK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[2-hydroxy-3-[C-phenyl-N-[4-(piperidin-1-ylmethyl)phenyl]carbonimidoyl]-1H-indol-5-yl]ethanesulfonamide
INCHI	InChI=1S/C29H32N4O3S/c1-2-37(35,36)32-24-15-16-26-25(19-24)27(29(34)31-26)28(22-9-5-3-6-10-22)30-23-13-11-21(12-14-23)20-33-17-7-4-8-18-33/h3,5-6,9-16,19,31-32,34H,2,4,7-8,17-18,20H2,1H3
InChi Key	HYHIYZMIFPJROG-UHFFFAOYSA-N
Canonical SMILES	CCS(=O)(=O)NC1=CC2=C(C=C1)NC(=C2C(=NC3=CC=C(C=C3)CN4CCCCC4)C5=CC=CC=C5)O
Isomeric SMILES	CCS(=O)(=O)NC1=CC2=C(C=C1)NC(=C2C(=NC3=CC=C(C=C3)CN4CCCCC4)C5=CC=CC=C5)O
PubChem CID	135421442
Molecular Weight	516.67

Database links

PubChem CID	135421442
CAS Registry No.	422513-13-1
ChEMBL Ligand	CHEMBL514409
Wikipedia	Hesperadin
RCSB PDB Ligand	FE7, FE7

Certificates

Certificate of Analysis(COA)

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Lot Number	Certificate Type	Date	Item
F1926003	Certificate of Analysis	Feb 07, 2023	H126784

Chemical and Physical Properties

Solubility	DMSO 103 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Melt Point(°C)	>226°C

FAQs and Articles

FAQ

Neurotransmitters, Receptors, and Transporters

Categories: Technical articles

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inhibitor Neurons neurotransmission

References

1. Hauf S, Cole RW, LaTerra S, Zimmer C, Schnapp G, Walter R, Heckel A, van Meel J, Rieder CL, Peters JM. (2003) The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.. J Cell Biol, 161 (2): (281-94). [PMID:12707311]

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SKU	Size	Availability	Price
H126784-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$64.90
H126784-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$292.90
H126784-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$489.90

Hesperadin - ≥98%, high purity , CAS No.422513-13-1, Inhibitor of aurora kinase B

Basic Description

Associated Targets

CXCL14 Tbio C-X-C motif chemokine 14 0 Activities

ERBB4 Tclin Receptor tyrosine-protein kinase erbB-4 0 Activities

ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities

EPHA1 Tchem Ephrin type-A receptor 1 0 Activities

EGFR Tclin Epidermal growth factor receptor 0 Activities

CDK16 Tchem Cyclin-dependent kinase 16 0 Activities

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

CDK5 Tchem Cyclin-dependent-like kinase 5 0 Activities

SRC Tclin Proto-oncogene tyrosine-protein kinase Src 0 Activities

FLT4 Tclin Vascular endothelial growth factor receptor 3 0 Activities

YES1 Tclin Tyrosine-protein kinase Yes 0 Activities

TYK2 Tclin Non-receptor tyrosine-protein kinase TYK2 0 Activities

HDAC6 Tclin Histone deacetylase 6 0 Activities

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 0 Activities

FGFR1 Tclin Fibroblast growth factor receptor 1 0 Activities

FGFR2 Tclin Fibroblast growth factor receptor 2 0 Activities

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

MET Tclin Hepatocyte growth factor receptor 0 Activities

IGF1R Tclin Insulin-like growth factor 1 receptor 0 Activities

MERTK Tchem Tyrosine-protein kinase Mer 0 Activities

SIK2 Tchem Serine/threonine-protein kinase SIK2 0 Activities

PLK4 Tchem Serine/threonine-protein kinase PLK4 0 Activities

PIM1 Tchem Serine/threonine-protein kinase pim-1 0 Activities

PDGFRA Tclin Platelet-derived growth factor receptor alpha 0 Activities

PIM2 Tchem Serine/threonine-protein kinase pim-2 0 Activities

MAP4K5 Tchem Mitogen-activated protein kinase kinase kinase kinase 5 0 Activities

BTK Tclin Tyrosine-protein kinase BTK 0 Activities

AURKA Tchem Aurora kinase A 0 Activities

AURKB Tchem Aurora kinase B 1 Activities

AURKC Tchem Aurora kinase C 0 Activities

FLT1 Tclin Vascular endothelial growth factor receptor 1 0 Activities

KDR Tclin Vascular endothelial growth factor receptor 2 0 Activities

AAK1 Tchem AP2-associated protein kinase 1 0 Activities

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

ACVRL1 Tchem Serine/threonine-protein kinase receptor R3 0 Activities

AKT3 Tchem RAC-gamma serine/threonine-protein kinase 0 Activities

AKT2 Tchem RAC-beta serine/threonine-protein kinase 0 Activities

AKT1 Tchem RAC-alpha serine/threonine-protein kinase 0 Activities

CLK3 Tchem Dual specificity protein kinase CLK3 0 Activities

CLK1 Tchem Dual specificity protein kinase CLK1 0 Activities

CLK2 Tchem Dual specificity protein kinase CLK2 0 Activities

CLK4 Tchem Dual specificity protein kinase CLK4 0 Activities

GSK3A Tclin Glycogen synthase kinase-3 alpha 0 Activities

SLC2A1 Tchem Solute carrier family 2, facilitated glucose transporter member 1 0 Activities

KIT Tclin Mast/stem cell growth factor receptor Kit 0 Activities

NTRK1 Tclin High affinity nerve growth factor receptor 0 Activities

JAK2 Tclin Tyrosine-protein kinase JAK2 0 Activities

Names and Identifiers

Database links

Certificates

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Chemical and Physical Properties

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References

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