Grouped product items

SKU

Size

Availability

Price

Qty

H408754-1ml

1ml

Available within 4-8 weeks(?)

$134.90

Basic Description

Specifications & Purity	Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms	Hesperetin is a bioflavonoid and, to be more specific, a flavanone.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Information Hesperetin is a bioflavonoid and, to be more specific, a flavanone. In vitro In vivo Cell Data cell lines： Concentrations： Incubation Time： Powder Purity:≥97%

Associated Targets(Human)

CYP1B1 Tchem Cytochrome P450 1B1 (1 Activities)

Discover Target: CYP1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DPP4 Tclin Dipeptidyl peptidase 4 (1 Activities)

Discover Target: DPP4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA4 Tclin Carbonic anhydrase 4 (1 Activities)

Discover Target: CA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA12 Tclin Carbonic anhydrase 12 (1 Activities)

Discover Target: CA12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA7 Tclin Carbonic anhydrase 7 (1 Activities)

Discover Target: CA7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Canonical SMILES	COC1=CC=C(C=C1O)C2CC(=O)C3=C(O)C=C(O)C=C3O2
Molecular Weight	302.27

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 100 mg/mL (417.2 mM); Water: 100 mg/mL (417.2 mM); Ethanol: 50 mg/mL (208.6 mM);

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Siqi Zhao, Yanzi Nan, Runyu Yao, Langhong Wang, Xinan Zeng, Rana Muhammad Aadil, Muhammad Asim Shabbir. (2023) Antibacterial Activity and Transcriptomic Analysis of Hesperetin against Alicyclobacillus acidoterrestris Vegetative Cells. Foods, 12 (17): (3276). [PMID:37685209] [10.3390/foods12173276]
2. Zhi Hu, Shucheng Liu, Nana Tang, Xuan Zhang, Jianming Pan. (2023) Hierarchically porous MOFs self-supporting copolymers for ultrafast transport and precise recognition of flavonoids: A triple interfacial crosslinking strategy based on microreactors. SEPARATION AND PURIFICATION TECHNOLOGY, 326 (124819). [PMID:] [10.1016/j.seppur.2023.124819]
3. Yufeng Chen, Guobin Xia, Chunfeng Wang, Huawei Wu, Xiaogang Xu, Genxiang Mao, Jiong Wu, Zhenlei Zhao. (2023) Impact of dietary plant flavonoids on 7,8-dihydroxyflavone transepithelial transport in human intestinal Caco-2 cells. Food Science & Nutrition, [PMID:37970375] [10.1002/fsn3.3581]
4. Shucheng Liu, Zhi Hu, Xingchen Yan, Senbai Geng, Xian Zhao, Hongxiang Ou, Jianming Pan. (2023) Separation and purification of target flavonoids using covalently connected MOFs@boronic acid-functionalized-COFs magnetic hybrids: Precise identification and enhanced stability. SEPARATION AND PURIFICATION TECHNOLOGY, 320 (124061). [PMID:] [10.1016/j.seppur.2023.124061]
5. Xi Peng, Xing Hu, Kai Liu, Deming Gong, Guowen Zhang. (2023) Exploring inhibitory effect and mechanism of hesperetin-Cu (II) complex against protein glycation. FOOD CHEMISTRY, 416 (135801). [PMID:36870150] [10.1016/j.foodchem.2023.135801]
6. Xinyue Hong, Xiaoqiao Luo, Langhong Wang, Deming Gong, Guowen Zhang. (2023) New Insights into the Inhibition of Hesperetin on Polyphenol Oxidase: Inhibitory Kinetics, Binding Characteristics, Conformational Change and Computational Simulation. Foods, 12 (4): (905). [PMID:36832979] [10.3390/foods12040905]
7. Pan Lixia, Ye Hangyu, Pi Xionge, Liu Wei, Wang Zhao, Zhang Yinjun, Zheng Jianyong. (2023) Effects of several flavonoids on human gut microbiota and its metabolism by in vitro simulated fermentation. Frontiers in Microbiology, 14 [PMID:36819019] [10.3389/fmicb.2023.1092729]
8. Chun Xiao Li, Fu Rong Wang, Bing Zhang, Ze Yuan Deng, Hong Yan Li. (2023) Stability and antioxidant activity of phenolic compounds during in vitro digestion. JOURNAL OF FOOD SCIENCE, 88 (2): (696-716). [PMID:36617678] [10.1111/1750-3841.16440]
9. Mang-Mang Li, Yi-Ting Chen, Jin-Cang Ruan, Wen-Jun Wang, Ji-Guang Chen, Qing-Feng Zhang. (2023) Structure-activity relationship of dietary flavonoids on pancreatic lipase. Current Research in Food Science, 6 (100424). [PMID:36618100] [10.1016/j.crfs.2022.100424]
10. Meilin Xu, Lunzhao Yi, Dabing Ren, Boyan Li. (2022) Mass defect filtering combined with molecular networking to profile flavonoids in citrus fruit based on liquid chromatography-high resolution mass spectrometry platform: Citrus sinensis (L.) Osbeck as a case study. JOURNAL OF CHROMATOGRAPHY A, 1685 (463640). [PMID:36375218] [10.1016/j.chroma.2022.463640]
11. Dan Yu, Fei Liu, Changdong Zou, Xiao Yang. (2023) Municipal green waste promotes iron release from steelmaking slag in water. RESOURCES CONSERVATION AND RECYCLING, 188 (106722). [PMID:] [10.1016/j.resconrec.2022.106722]
12. Lu Youluan, Mu Xinwei, Liu Yaopeng, Shi Zhen, Zheng Yin, Huang Wensheng, Lou Fangming. (2022) Biomass porous carbon prepared by endogenous template for electrochemical sensing of hesperetin. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS, 33 (14): (11446-11454). [PMID:] [10.1007/s10854-022-08117-9]
13. Haihua Jiang, Xing Hu, Junhui Pan, Deming Gong, Guowen Zhang. (2022) Effects of interaction between hesperetin/hesperidin and glutenin on the structure and functional properties of glutenin. LWT-FOOD SCIENCE AND TECHNOLOGY, 155 (112983). [PMID:] [10.1016/j.lwt.2021.112983]
14. Jing Liang, Ke Min, Piao Long, Xuqian Weng, Qun Huang, Bo Chen, Ming Ma. (2021) Selective adsorption of flavonoids on cerium-doped ferroferric oxide magnetic particles. JOURNAL OF CHROMATOGRAPHY A, 1648 (462189). [PMID:33975082] [10.1016/j.chroma.2021.462189]
15. Yu-Meng Jia, Ting Zhu, Huan Zhou, Jin-Zi Ji, Ting Tai, Hong-Guang Xie. (2020) Multidrug Resistance–Associated Protein 3 Is Responsible for the Efflux Transport of Curcumin Glucuronide from Hepatocytes to the Blood. DRUG METABOLISM AND DISPOSITION, 48 (10): (966-971). [PMID:31900255] [10.1124/dmd.119.089193]
16. Yan Jin Gao, Wei Jie Fu, Jia Liu, Yi Juan Chen, Guang Hui Dai. (2020) Morphological changes of Podosphaera xanthii and induced biochemical defenses of cucumber after treated by (+)-(S)-ar-turmerone. PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY, 112 (101524). [PMID:] [10.1016/j.pmpp.2020.101524]
17. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu. (2019) Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies. Foods, 8 (9): (355). [PMID:31438605] [10.3390/foods8090355]
18. Qian Liu, Hai-Long Wu, Zhi Liu, Rong Xiao, Tong Wang, Yong Hu, Yu-Jie Ding, Ru-Qin Yu. (2018) Chemometrics-assisted HPLC-DAD as a rapid and interference-free strategy for simultaneous determination of 17 polyphenols in raw propolis. Analytical Methods, 10 (46): (5577-5588). [PMID:] [10.1039/C8AY01986J]
19. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan. (2017) The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum. FOOD CHEMISTRY, 224 (26). [PMID:28159264] [10.1016/j.foodchem.2016.12.001]
20. Junjun Wu, Lu Wang, Qinqin Wang, Lina Zou, Baoxian Ye. (2016) The novel voltammetric method for determination of hesperetin based on a sensitive electrochemical sensor. TALANTA, 150 (61). [PMID:26838382] [10.1016/j.talanta.2015.12.026]
21. Kitty S.C. Tang, Izabela Konczak, Jian Zhao. (2016) Identification and quantification of phenolics in Australian native mint (Mentha australis R. Br.). FOOD CHEMISTRY, 192 (698). [PMID:26304400] [10.1016/j.foodchem.2015.07.032]
22. Na Li,Liyan Liu,Huiqing Luo,Huaqiao Wang,Depo Yang,Feng He. (2020-07-28) Flavanone-Based Fluorophores with Aggregation-Induced Emission Enhancement Characteristics for Mitochondria-Imaging and Zebrafish-Imaging.. Molecules (Basel, Switzerland), 25 ((14)): [PMID:32708080]

References

1. Siqi Zhao, Yanzi Nan, Runyu Yao, Langhong Wang, Xinan Zeng, Rana Muhammad Aadil, Muhammad Asim Shabbir. (2023) Antibacterial Activity and Transcriptomic Analysis of Hesperetin against Alicyclobacillus acidoterrestris Vegetative Cells. Foods, 12 (17): (3276). [PMID:37685209] [10.3390/foods12173276]
2. Zhi Hu, Shucheng Liu, Nana Tang, Xuan Zhang, Jianming Pan. (2023) Hierarchically porous MOFs self-supporting copolymers for ultrafast transport and precise recognition of flavonoids: A triple interfacial crosslinking strategy based on microreactors. SEPARATION AND PURIFICATION TECHNOLOGY, 326 (124819). [PMID:] [10.1016/j.seppur.2023.124819]
3. Yufeng Chen, Guobin Xia, Chunfeng Wang, Huawei Wu, Xiaogang Xu, Genxiang Mao, Jiong Wu, Zhenlei Zhao. (2023) Impact of dietary plant flavonoids on 7,8-dihydroxyflavone transepithelial transport in human intestinal Caco-2 cells. Food Science & Nutrition, [PMID:37970375] [10.1002/fsn3.3581]
4. Shucheng Liu, Zhi Hu, Xingchen Yan, Senbai Geng, Xian Zhao, Hongxiang Ou, Jianming Pan. (2023) Separation and purification of target flavonoids using covalently connected MOFs@boronic acid-functionalized-COFs magnetic hybrids: Precise identification and enhanced stability. SEPARATION AND PURIFICATION TECHNOLOGY, 320 (124061). [PMID:] [10.1016/j.seppur.2023.124061]
5. Xi Peng, Xing Hu, Kai Liu, Deming Gong, Guowen Zhang. (2023) Exploring inhibitory effect and mechanism of hesperetin-Cu (II) complex against protein glycation. FOOD CHEMISTRY, 416 (135801). [PMID:36870150] [10.1016/j.foodchem.2023.135801]
6. Xinyue Hong, Xiaoqiao Luo, Langhong Wang, Deming Gong, Guowen Zhang. (2023) New Insights into the Inhibition of Hesperetin on Polyphenol Oxidase: Inhibitory Kinetics, Binding Characteristics, Conformational Change and Computational Simulation. Foods, 12 (4): (905). [PMID:36832979] [10.3390/foods12040905]
7. Pan Lixia, Ye Hangyu, Pi Xionge, Liu Wei, Wang Zhao, Zhang Yinjun, Zheng Jianyong. (2023) Effects of several flavonoids on human gut microbiota and its metabolism by in vitro simulated fermentation. Frontiers in Microbiology, 14 [PMID:36819019] [10.3389/fmicb.2023.1092729]
8. Chun Xiao Li, Fu Rong Wang, Bing Zhang, Ze Yuan Deng, Hong Yan Li. (2023) Stability and antioxidant activity of phenolic compounds during in vitro digestion. JOURNAL OF FOOD SCIENCE, 88 (2): (696-716). [PMID:36617678] [10.1111/1750-3841.16440]
9. Mang-Mang Li, Yi-Ting Chen, Jin-Cang Ruan, Wen-Jun Wang, Ji-Guang Chen, Qing-Feng Zhang. (2023) Structure-activity relationship of dietary flavonoids on pancreatic lipase. Current Research in Food Science, 6 (100424). [PMID:36618100] [10.1016/j.crfs.2022.100424]
10. Meilin Xu, Lunzhao Yi, Dabing Ren, Boyan Li. (2022) Mass defect filtering combined with molecular networking to profile flavonoids in citrus fruit based on liquid chromatography-high resolution mass spectrometry platform: Citrus sinensis (L.) Osbeck as a case study. JOURNAL OF CHROMATOGRAPHY A, 1685 (463640). [PMID:36375218] [10.1016/j.chroma.2022.463640]
11. Dan Yu, Fei Liu, Changdong Zou, Xiao Yang. (2023) Municipal green waste promotes iron release from steelmaking slag in water. RESOURCES CONSERVATION AND RECYCLING, 188 (106722). [PMID:] [10.1016/j.resconrec.2022.106722]
12. Lu Youluan, Mu Xinwei, Liu Yaopeng, Shi Zhen, Zheng Yin, Huang Wensheng, Lou Fangming. (2022) Biomass porous carbon prepared by endogenous template for electrochemical sensing of hesperetin. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS, 33 (14): (11446-11454). [PMID:] [10.1007/s10854-022-08117-9]
13. Haihua Jiang, Xing Hu, Junhui Pan, Deming Gong, Guowen Zhang. (2022) Effects of interaction between hesperetin/hesperidin and glutenin on the structure and functional properties of glutenin. LWT-FOOD SCIENCE AND TECHNOLOGY, 155 (112983). [PMID:] [10.1016/j.lwt.2021.112983]
14. Jing Liang, Ke Min, Piao Long, Xuqian Weng, Qun Huang, Bo Chen, Ming Ma. (2021) Selective adsorption of flavonoids on cerium-doped ferroferric oxide magnetic particles. JOURNAL OF CHROMATOGRAPHY A, 1648 (462189). [PMID:33975082] [10.1016/j.chroma.2021.462189]
15. Yu-Meng Jia, Ting Zhu, Huan Zhou, Jin-Zi Ji, Ting Tai, Hong-Guang Xie. (2020) Multidrug Resistance–Associated Protein 3 Is Responsible for the Efflux Transport of Curcumin Glucuronide from Hepatocytes to the Blood. DRUG METABOLISM AND DISPOSITION, 48 (10): (966-971). [PMID:31900255] [10.1124/dmd.119.089193]
16. Yan Jin Gao, Wei Jie Fu, Jia Liu, Yi Juan Chen, Guang Hui Dai. (2020) Morphological changes of Podosphaera xanthii and induced biochemical defenses of cucumber after treated by (+)-(S)-ar-turmerone. PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY, 112 (101524). [PMID:] [10.1016/j.pmpp.2020.101524]
17. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu. (2019) Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies. Foods, 8 (9): (355). [PMID:31438605] [10.3390/foods8090355]
18. Qian Liu, Hai-Long Wu, Zhi Liu, Rong Xiao, Tong Wang, Yong Hu, Yu-Jie Ding, Ru-Qin Yu. (2018) Chemometrics-assisted HPLC-DAD as a rapid and interference-free strategy for simultaneous determination of 17 polyphenols in raw propolis. Analytical Methods, 10 (46): (5577-5588). [PMID:] [10.1039/C8AY01986J]
19. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan. (2017) The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum. FOOD CHEMISTRY, 224 (26). [PMID:28159264] [10.1016/j.foodchem.2016.12.001]
20. Junjun Wu, Lu Wang, Qinqin Wang, Lina Zou, Baoxian Ye. (2016) The novel voltammetric method for determination of hesperetin based on a sensitive electrochemical sensor. TALANTA, 150 (61). [PMID:26838382] [10.1016/j.talanta.2015.12.026]
21. Kitty S.C. Tang, Izabela Konczak, Jian Zhao. (2016) Identification and quantification of phenolics in Australian native mint (Mentha australis R. Br.). FOOD CHEMISTRY, 192 (698). [PMID:26304400] [10.1016/j.foodchem.2015.07.032]
22. Na Li,Liyan Liu,Huiqing Luo,Huaqiao Wang,Depo Yang,Feng He. (2020-07-28) Flavanone-Based Fluorophores with Aggregation-Induced Emission Enhancement Characteristics for Mitochondria-Imaging and Zebrafish-Imaging.. Molecules (Basel, Switzerland), 25 ((14)): [PMID:32708080]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Hesperetin - 10mM in DMSO, high purity , CAS No.520-33-2(DMSO)