| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| H432824-5g | 5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $34.90 | |
| H432824-25g | 25g | In stock | $84.90 | |
| H432824-100g | 100g | In stock | $267.90 |
| Synonyms | hesperidin|Cirantin|520-26-3|Hesperidoside|Hesper bitabs|Hesperetin 7-rutinoside|Hesperetin-rutinosid|Hesperidine|Ciratin|(S)-(-)-Hesperidin|Hesperetin 7-O-rutinoside|Hesperetin 7-rhamnoglucoside|CCRIS 3940|EINECS 208-288-1|(2S)-Hesperidin|NSC 44184|UNII- |
|---|---|
| Specifications & Purity | ≥80% |
| Storage Temp | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | Application Studies of the behavior of hesperidin and hesperetin (the aglycone) with DMPC liposomes find the aglycone penetrates more deeply and binds more strongly to the "membrane." This may explain the better bioavailability of bioflavonoid aglycones in general. Other Notes Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. H5254.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit .com/metlin. |
| IUPAC Name | (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one |
|---|---|
| INCHI | InChI=1S/C28H34O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-7,10,17,19,21-30,32-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1 |
| InChi Key | QUQPHWDTPGMPEX-QJBIFVCTSA-N |
| Canonical SMILES | CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O |
| Isomeric SMILES | C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=O)C[C@H](OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O |
| WGK Germany | 3 |
| PubChem CID | 10621 |
| Molecular Weight | 610.56 |
| Beilstein | 75140 |
Enter Lot Number to search for COA:
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 G2416108 | Certificate of Analysis | Apr 10, 2024 | H432824 |
| G2416109 | Certificate of Analysis | Apr 10, 2024 | H432824 |
| C2413034 | Certificate of Analysis | Apr 26, 2023 | H432824 |
| D2419029 | Certificate of Analysis | Apr 26, 2023 | H432824 |
| E2312188 | Certificate of Analysis | Apr 26, 2023 | H432824 |
| E2312200 | Certificate of Analysis | Apr 26, 2023 | H432824 |
| E2312212 | Certificate of Analysis | Apr 26, 2023 | H432824 |
| E2312257 | Certificate of Analysis | Apr 26, 2023 | H432824 |
| Melt Point(°C) | 250-255°C |
|---|
| WGK Germany | 3 |
|---|---|
| Merck Index | 4671 |
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| 3. Takuji Tanaka,Takahiro Tanaka,Mayu Tanaka,Toshiya Kuno. (2011-12-17) Cancer chemoprevention by citrus pulp and juices containing high amounts of β-cryptoxanthin and hesperidin.. Journal of biomedicine & biotechnology, 2012 (516981-516981). [PMID:22174562] |
| 4. Binit Kumar,Suresh Kumar Gupta,B P Srinivasan,Tapas Chandra Nag,Sushma Srivastava,Rohit Saxena. (2012-09-13) Hesperetin ameliorates hyperglycemia induced retinal vasculopathy via anti-angiogenic effects in experimental diabetic rats.. Vascular pharmacology, 57 ((5-6)): (201-207). [PMID:22967957] |
| 5. Leandro C Souza,Marcelo G de Gomes,André T R Goes,Lucian Del Fabbro,Carlos B Filho,Silvana P Boeira,Cristiano R Jesse. (2012-09-22) Evidence for the involvement of the serotonergic 5-HT(1A) receptors in the antidepressant-like effect caused by hesperidin in mice.. Progress in neuro-psychopharmacology & biological psychiatry, 40 (103-109). [PMID:22996046] |
| 6. Baoshun Zhang,Tingting Chen,Zhu Chen,Mingxue Wang,Dengyu Zheng,Jinfeng Wu,Xiaofei Jiang,Xuegang Li. (2012-10-17) Synthesis and anti-hyperglycemic activity of hesperidin derivatives.. Bioorganic & medicinal chemistry letters, 22 ((23)): (7194-7197). [PMID:23067551] |
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| 8. Jinhua Li,Sumin Wang. (2012-12-12) Molecular spectroscopic on interaction between Methyl hesperidin and Buman serum albumin.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 102 (200-204). [PMID:23220657] |
| 9. Ousmane Ilboudo,Issa Tapsoba,Yvonne L Bonzi-Coulibaly,Pascal Gerbaux. (2012-12-12) Targeting structural motifs of flavonoid diglycosides using collision-induced dissociation experiments on flavonoid/Pb2+ complexes.. European journal of mass spectrometry (Chichester, England), 18 ((5)): (465-473). [PMID:23221119] |
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| 18. V Sridhar,M Surya Sandeep,P Ravindra Babu,K Naveen Babu. (2013-07-25) Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using felodipine and hesperetin in combination in Wistar rats and everted rat gut sacs in vitro.. Phytotherapy research : PTR, 28 ((5)): (699-705). [PMID:23881850] |
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| 24. Su-Chen Ho,Chun-Ting Kuo. (2014-06-24) Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium).. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 71 (176-182). [PMID:24955543] |
| 25. Maryam Hamzeh-Mivehroud,Seifullah Rahmani,Mohammad-Ali Hosseinpour Feizi,Siavoush Dastmalchi,Mohammad-Reza Rashidi. (2014-06-24) In vitro and in silico studies to explore structural features of flavonoids for aldehyde oxidase inhibition.. Archiv der Pharmazie, 347 ((10)): (738-747). [PMID:24956178] |
| 26. Gowrikumar Saiprasad,Palanivel Chitra,Ramar Manikandan,Ganapasam Sudhandiran. (2014-07-23) Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis.. European journal of cancer (Oxford, England : 1990), 50 ((14)): (2489-2507). [PMID:25047426] |
| 27. Otilia J F Banji,David Banji,Kalpana Ch. (2014-09-15) Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by D-galactose in rat brain.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 74 (51-59). [PMID:25217884] |
| 28. John T Barr,Jeffrey P Jones,Nicholas H Oberlies,Mary F Paine. (2014-10-19) Inhibition of human aldehyde oxidase activity by diet-derived constituents: structural influence, enzyme-ligand interactions, and clinical relevance.. Drug metabolism and disposition: the biological fate of chemicals, 43 ((1)): (34-41). [PMID:25326286] |
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| 51. Chia Ying Chang,Tzu Yu Lin,Cheng Wei Lu,Shu Kuei Huang,Ying Chou Wang,Shang Shing Peter Chou,Su Jane Wang. (2015-09-08) Hesperidin inhibits glutamate release and exerts neuroprotection against excitotoxicity induced by kainic acid in the hippocampus of rats.. Neurotoxicology, 50 (157-169). [PMID:26342684] |
| 52. Takashi Matsumoto,Yousuke Matsubara,Yasuharu Mizuhara,Kyoji Sekiguchi,Junichi Koseki,Kazuaki Tsuchiya,Hiroaki Nishimura,Junko Watanabe,Atsushi Kaneko,Kazuya Maemura,Tomohisa Hattori,Yoshio Kase. (2015-10-06) Plasma Pharmacokinetics of Polyphenols in a Traditional Japanese Medicine, Jumihaidokuto, Which Suppresses Propionibacterium acnes-Induced Dermatitis in Rats.. Molecules (Basel, Switzerland), 20 ((10)): (18031-18046). [PMID:26437394] |
| 53. Nurcan Değirmencioğlu,Ozan Gürbüz,Emine Nur Herken,Aysun Yurdunuseven Yıldız. (2015-10-17) The impact of drying techniques on phenolic compound, total phenolic content and antioxidant capacity of oat flour tarhana.. Food chemistry, 194 (587-594). [PMID:26471596] |
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| 56. Benjamin Dilberger,Maike Passon,Heike Asseburg,Carmina V Silaidos,Fabian Schmitt,Tommy Schmiedl,Andreas Schieber,Gunter P Eckert. (2019-08-16) Polyphenols and Metabolites Enhance Survival in Rodents and Nematodes-Impact of Mitochondria.. Nutrients, 11 ((8)): [PMID:31412639] |
| 57. Wanthanee Hanchang,Aree Khamchan,Navinee Wongmanee,Chananchida Seedadee. (2019-09-11) Hesperidin ameliorates pancreatic β-cell dysfunction and apoptosis in streptozotocin-induced diabetic rat model.. Life sciences, 235 (116858-116858). [PMID:31505195] |
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| 59. Young-Su Lee,Ji-Young Huh,So-Hyun Nam,Sung-Kwon Moon,Soo-Bok Lee. (2012-09-18) Enzymatic bioconversion of citrus hesperidin by Aspergillus sojae naringinase: enhanced solubility of hesperetin-7-O-glucoside with in vitro inhibition of human intestinal maltase, HMG-CoA reductase, and growth of Helicobacter pylori.. Food chemistry, 135 ((4)): (2253-2259). [PMID:22980799] |
| 60. Xiupu Shi,Sha Liao,Huijuan Mi,Changrun Guo,Dongli Qi,Fei Li,Chunfeng Zhang,Zhonglin Yang. (2012-11-03) Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats.. Molecules (Basel, Switzerland), 17 ((11)): (12868-12881). [PMID:23117428] |
| 61. Yoshiyuki Shirasaka,Meg. (2012-11-08) Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.. Journal of pharmaceutical sciences, 102 ((1)): (280-288). [PMID:23132664] |
| 62. Yong Yang,Joy Wolfram,Haifa Shen,Xiaohong Fang,Mauro Ferrari. (2012-11-17) Hesperetin: an inhibitor of the transforming growth factor-β (TGF-β) signaling pathway.. European journal of medicinal chemistry, 58 (390-395). [PMID:23153811] |
| 63. A Cengiz,S Tabak,S Kuru,A H Demirel,A M Barlas,T Altun,M Gonultas,S Celepli,S S Kilicoglu,A Aydogan,B Kilicoglu. (2012-11-24) Effects of diosmine-hesperidine on experimental colonic anastomosis.. Bratislavske lekarske listy, 113 ((12)): (692-697). [PMID:23173625] |
| 64. Carlos B Filho,Lucian Del Fabbro,Marcelo G de Gomes,André T R Goes,Leandro C Souza,Silvana P Boeira,Cristiano R Jesse. (2012-11-28) Kappa-opioid receptors mediate the antidepressant-like activity of hesperidin in the mouse forced swimming test.. European journal of pharmacology, 698 ((1-3)): (286-291). [PMID:23178563] |
| 65. Fei Xu,Jia Zang,Daozhen Chen,Ting Zhang,Huiying Zhan,Mudan Lu,Hongxiang Zhuge. (2013-01-05) Neohesperidin induces cellular apoptosis in human breast adenocarcinoma MDA-MB-231 cells via activating the Bcl-2/Bax-mediated signaling pathway.. Natural product communications, 7 ((11)): (1475-1478). [PMID:23285810] |
| 66. Yujing Sun,Liping Qiao,Yan Shen,Ping Jiang,Jianchu Chen,Xingqian Ye. (2013-01-11) Phytochemical profile and antioxidant activity of physiological drop of citrus fruits.. Journal of food science, 78 ((1)): (C37-C42). [PMID:23301602] |
| 67. Takeru Naiki,Yuki Kurose,Kozaburo Hayashi,Hiroko Takumi,Takashi Kometani. (2013-02-06) Effects of long-term feeding of α-glucosylhesperidin on the mechanical properties of rabbit femoral arteries.. Biorheology, 49 ((5-6)): (353-363). [PMID:23380901] |
| 68. Laura S Mazzaferro,Javier D Breccia. (2013-02-28) Quantification of hesperidin in citrus-based foods using a fungal diglycosidase.. Food chemistry, 134 ((4)): (2338-2344). [PMID:23442693] |
| 69. Ji-Jun Wang,Ping Cui. (2013-08-21) Neohesperidin attenuates cerebral ischemia-reperfusion injury via inhibiting the apoptotic pathway and activating the Akt/Nrf2/HO-1 pathway.. Journal of Asian natural products research, 15 ((9)): (1023-1037). [PMID:23952707] |
| 70. A A Kamboh,S Q Hang,M Bakhetgul,W-Y Zhu. (2013-08-21) Effects of genistein and hesperidin on biomarkers of heat stress in broilers under persistent summer stress.. Poultry science, 92 ((9)): (2411-2418). [PMID:23960125] |
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