Hesperidin - ≥80%, high purity , CAS No.520-26-3

  • ≥80%
Item Number
H432824
Grouped product items
SKUSizeAvailabilityPrice Qty
H432824-5g
5g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$34.90
H432824-25g
25g
In stock
$84.90
H432824-100g
100g
In stock
$267.90

Basic Description

Synonyms(2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside | CHEBI:28775 | DIOSVEIN | EINECS 208-288-1 | Hesperetin 7 Rhamnoglucoside | Q385937 | D01038 | hesperidin | DTXSID9
Specifications & Purity≥80%
Biochemical and Physiological MechanismsFlavonoid phytochemical extracted from citrus species. It is the rhamnoglucoside (rutinoside) of hesperetin.
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
Product Description

Application

Studies of the behavior of hesperidin and hesperetin (the aglycone) with DMPC liposomes find the aglycone penetrates more deeply and binds more strongly to the "membrane." This may explain the better bioavailability of bioflavonoid aglycones in general.


Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. H5254.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit .com/metlin.

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FABP4 Tchem Fatty acid binding protein adipocyte (764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APP Tclin Amyloid-beta A4 protein (8510 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HPSE Tchem Heparanase (634 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BACE1 Tchem Beta-secretase 1 (15641 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Caco-2 (12174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DLD-1 (17511 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
H9 (1832 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Monocyte (474 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL (112 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLH Tchem DNA polymerase eta (21678 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM1A Tchem Lysine-specific histone demethylase 1 (3916 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CTDSP1 Tchem Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (1031 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CACNA1B Tclin Voltage-gated N-type calcium channel alpha-1B subunit/Amyloid beta A4 precursor protein-binding family A member 1 (925 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

NA Neuraminidase (1107 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Chlamydia pneumoniae (241 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Proteus vulgaris (5823 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Salmonella typhimurium (15756 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Proteus mirabilis (3894 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human immunodeficiency virus 1 (70413 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
3T3-L1 (3664 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCRF S-180 (1031 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L1210 (27553 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CALM Calmodulin (71 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slco1a5 Solute carrier organic anion transporter family member 1A5 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one
INCHI InChI=1S/C28H34O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-7,10,17,19,21-30,32-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1
InChi Key QUQPHWDTPGMPEX-QJBIFVCTSA-N
Canonical SMILES COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2
Isomeric SMILES C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=O)C[C@H](OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O
WGK Germany 3
Molecular Weight 610.56
Beilstein 75140

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot NumberCertificate TypeDateItem
G2416108Certificate of AnalysisApr 10, 2024 H432824
G2416109Certificate of AnalysisApr 10, 2024 H432824
C2413034Certificate of AnalysisApr 26, 2023 H432824
D2419029Certificate of AnalysisApr 26, 2023 H432824
E2312188Certificate of AnalysisApr 26, 2023 H432824
E2312200Certificate of AnalysisApr 26, 2023 H432824
E2312212Certificate of AnalysisApr 26, 2023 H432824
E2312257Certificate of AnalysisApr 26, 2023 H432824
J2424336Certificate of AnalysisApr 26, 2023 H432824

Chemical and Physical Properties

SensitivityAir sensitive
Melt Point(°C)250-255°C

Safety and Hazards(GHS)

WGK Germany 3
Merck Index 4671

Related Documents

Citations of This Product

1. Min-Rui Tai, Hong-Wu Ji, Jian-Ping Chen, Xiao-Fei Liu, Bing-Bing Song, Sai-Yi Zhong, Aaqil Rifai, David R. Nisbet, Colin J. Barrow, Richard J. Williams, Rui Li.  (2023)  Biomimetic triumvirate nanogel complexes via peptide-polysaccharide-polyphenol self-assembly.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  251  (126232).  [PMID:37562478] [10.1016/j.ijbiomac.2023.126232]
2. Hong-Qi Xia, Wanbing Chen, Diyang Qiu, Jiwu Zeng.  (2023)  Portable Microelectrochemical Sensors for Rapid and Sensitive Determination of Hesperidin in Citrus reticulate ‘Chachi’ Peel.  MOLECULES,  28  (14): (5316).  [PMID:37513189] [10.3390/molecules28145316]
3. Xiao-Hua Zhang, Xiang-Dong Qing, Jing-Jing Zheng, Yan Yu, Jiaojiao Huang, Chao Kang, Zhi Liu.  (2023)  Aqueous two-phase systems coupled with chemometrics-enhanced HPLC-DAD for simultaneous extraction and determination of flavonoids in honey.  Food Chemistry-X,  19  (100766).  [PMID:37780266] [10.1016/j.fochx.2023.100766]
4. Shengxiang Yi, Gaowei Zhang, Mingyan Liu, Wenjie Yu, Guohua Cheng, Liping Luo, Fangjian Ning.  (2023)  Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice.  Nutrients,  15  (5): (1078).  [PMID:36904078] [10.3390/nu15051078]
5. Pan Lixia, Ye Hangyu, Pi Xionge, Liu Wei, Wang Zhao, Zhang Yinjun, Zheng Jianyong.  (2023)  Effects of several flavonoids on human gut microbiota and its metabolism by in vitro simulated fermentation.  Frontiers in Microbiology,  14    [PMID:36819019] [10.3389/fmicb.2023.1092729]
6. Hong-qi Xia, Diyang Qiu, Wanbing Chen, Genlin Mao, Jiwu Zeng.  (2023)  In situ formed and fully integrated laser-induced graphene electrochemical chips for rapid and simultaneous determination of bioflavonoids in citrus fruits.  MICROCHEMICAL JOURNAL,  188  (108474).  [PMID:] [10.1016/j.microc.2023.108474]
7. Chun Xiao Li, Fu Rong Wang, Bing Zhang, Ze Yuan Deng, Hong Yan Li.  (2023)  Stability and antioxidant activity of phenolic compounds during in vitro digestion.  JOURNAL OF FOOD SCIENCE,  88  (2): (696-716).  [PMID:36617678] [10.1111/1750-3841.16440]
8. Wenjie Yu, Fengjie Sun, Ruixin Xu, Meng Cui, Yongquan Liu, Quanyuan Xie, Limin Guo, Chenxian Kong, Xin Li, Xiali Guo, Liping Luo.  (2023)  Chemical composition and anti-inflammatory activities of Castanopsis honey.  Food & Function,  14  (1): (250-261).  [PMID:36484340] [10.1039/D2FO02233H]
9. Yu Bo, Luo Shiyu, Ding Yuhan, Gong Zijie, Nie Ting.  (2022)  Insights into glycosidic bond specificity of an engineered selective α-L-rhamnosidase N12-Rha via activity assays and molecular modelling.  AMB Express,  12  (1): (1-14).  [PMID:36370155] [10.1186/s13568-022-01489-5]
10. Dan Yu, Fei Liu, Changdong Zou, Xiao Yang.  (2023)  Municipal green waste promotes iron release from steelmaking slag in water.  RESOURCES CONSERVATION AND RECYCLING,  188  (106722).  [PMID:] [10.1016/j.resconrec.2022.106722]
11. Ye Hangyu, Li Xiaojun, Li Luyuan, Zhang Yinjun, Zheng Jianyong.  (2022)  Homologous Expression and Characterization of α-L-rhamnosidase from Aspergillus niger for the Transformation of Flavonoids.  APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,  194  (8): (3453-3467).  [PMID:35366188] [10.1007/s12010-022-03894-9]
12. Hong-qi Xia, Tingting Gu, Ruiyi Fan, Jiwu Zeng.  (2022)  Comparative investigation of bioflavonoid electrocatalysis in 1D, 2D, and 3D carbon nanomaterials for simultaneous detection of naringin and hesperidin in fruits.  RSC Advances,  12  (11): (6409-6415).  [PMID:35424592] [10.1039/D1RA07217J]
13. Xiangrong Li, Ruonan Xu, Zeqing Cheng, Zhizhi Song, Ziyang Wang, Hanxiao Duan, Xinzhe Wu, Tianjun Ni.  (2021)  Comparative study on the interaction between flavonoids with different core structures and hyaluronidase.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  262  (120079).  [PMID:34175762] [10.1016/j.saa.2021.120079]
14. Dan-Hua He, Yu-Fei Chen, Yi-Le Zhou, Shi-Bing Zhang, Ming Hong, Xianjun Yu, Su-Fen Wei, Xiang-Zhen Fan, Si-Yi Li, Qi Wang, Yongzhi Lu, Yong-Qiang Liu.  (2021)  Phytochemical library screening reveals betulinic acid as a novel Skp2-SCF E3 ligase inhibitor in non–small cell lung cancer.  CANCER SCIENCE,  112  (8): (3218-3232).  [PMID:34080260] [10.1111/cas.15005]
15. Lingrong Wen, Mingyang He, Chunxiao Yin, Yueming Jiang, Donghui Luo, Bao Yang.  (2021)  Phenolics in Citrus aurantium fruit identified by UHPLC-MS/MS and their bioactivities.  LWT-FOOD SCIENCE AND TECHNOLOGY,  147  (111671).  [PMID:] [10.1016/j.lwt.2021.111671]
16. Zhang Xiao-Hua, Ma Yi-Xin, Yi Chong, Qing Xiang-Dong, Liu Zhi, Zheng Jing-Jing, Lin Fang, Lv Tian-Feng.  (2020)  Chemometrics-enhanced HPLC–DAD as a rapid and interference-free strategy for simultaneous quantitative analysis of flavonoids in Chinese propolis.  EUROPEAN FOOD RESEARCH AND TECHNOLOGY,  246  (10): (1909-1918).  [PMID:] [10.1007/s00217-020-03543-7]
17. Hui Guo, Yunfei Chen, Na Song, Xinyi Yang, Shen Yao, Junqing Qian.  (2020)  Screening of lipase inhibitors from bamboo leaves based on the magnetic ligand fishing combined with HPLC/MS.  MICROCHEMICAL JOURNAL,  153  (104497).  [PMID:] [10.1016/j.microc.2019.104497]
18. Xinlin Chen, Shang Xue, Yaolan Lin, Jianguang Luo, Lingyi Kong.  (2020)  Immobilization of porcine pancreatic lipase onto a metal-organic framework, PPL@MOF: A new platform for efficient ligand discovery from natural herbs.  ANALYTICA CHIMICA ACTA,  1099  (94).  [PMID:31986282] [10.1016/j.aca.2019.11.042]
19. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu.  (2019)  Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies.  Foods,  (9): (355).  [PMID:31438605] [10.3390/foods8090355]
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21. Shi Shen,Jingbo Wang,Qin Zhuo,Xi Chen,Tingting Liu,Shuang-Qing Zhang.  (2018-05-09)  Quantitative and Discriminative Evaluation of Contents of Phenolic and Flavonoid and Antioxidant Competence for Chinese Honeys from Different Botanical Origins..  Molecules (Basel, Switzerland),  23  ((5)):   [PMID:29738446]

References

1. F La Torre,A P Nicolai,M Otti.  (2000-03-29)  [Hemorrhoids and conservative treatment. Review of the literature on the use of diosmin and micronized hesperidin]..  Minerva chirurgica,  54  ((12)): (909-916).  [PMID:10736998]
2. A Garg,S Garg,L J Zaneveld,A K Singla.  (2001-12-18)  Chemistry and pharmacology of the Citrus bioflavonoid hesperidin..  Phytotherapy research : PTR,  15  ((8)): (655-669).  [PMID:11746857]
3. Takuji Tanaka,Takahiro Tanaka,Mayu Tanaka,Toshiya Kuno.  (2011-12-17)  Cancer chemoprevention by citrus pulp and juices containing high amounts of β-cryptoxanthin and hesperidin..  Journal of biomedicine & biotechnology,  2012  (516981-516981).  [PMID:22174562]
4. Binit Kumar,Suresh Kumar Gupta,B P Srinivasan,Tapas Chandra Nag,Sushma Srivastava,Rohit Saxena.  (2012-09-13)  Hesperetin ameliorates hyperglycemia induced retinal vasculopathy via anti-angiogenic effects in experimental diabetic rats..  Vascular pharmacology,  57  ((5-6)): (201-207).  [PMID:22967957]
5. Leandro C Souza,Marcelo G de Gomes,André T R Goes,Lucian Del Fabbro,Carlos B Filho,Silvana P Boeira,Cristiano R Jesse.  (2012-09-22)  Evidence for the involvement of the serotonergic 5-HT(1A) receptors in the antidepressant-like effect caused by hesperidin in mice..  Progress in neuro-psychopharmacology & biological psychiatry,  40  (103-109).  [PMID:22996046]
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21. Sophie Dufay,Alan Worsley,Aymeric Monteillier,Charlotte Avanzi,Jaclyn Sy,Ting Fat Ng,Jean-Michel Garcia,Man-Fai Lam,Paul Vanhoutte,Ian C K Wong.  (2014-05-16)  Herbal tea extracts inhibit Cytochrome P450 3A4 in vitro..  The Journal of pharmacy and pharmacology,  66  ((10)): (1478-1490).  [PMID:24824478]
22. Wanpeng Xi,Bo Fang,Qiyang Zhao,Bining Jiao,Zhiqin Zhou.  (2014-05-20)  Flavonoid composition and antioxidant activities of Chinese local pummelo (Citrus grandis Osbeck.) varieties..  Food chemistry,  161  (230-238).  [PMID:24837945]
23. Partha Pratim Roy,Sarbani Dey Ray,Supratim Ray.  (2014-06-03)  Combined experimental and in silico approaches for exploring antiperoxidative potential of structurally diverse classes of antioxidants on docetaxel-induced lipid peroxidation using 4-HNE as the model marker..  Bioorganic chemistry,  56  (1-7).  [PMID:24887149]
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Solution Calculators