Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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H107699-20mg | 20mg | In stock | $62.90 |
Apoptotic and anti-inflammatory agent. PPARγ inducer.
Synonyms | Hesperitin; Hesperin; YSO2; Prestwick_908 | (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one | (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one | BDBM23418 | BRD-K30553453-001-08-2 | Eriodictyol 4'-mon |
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Specifications & Purity | Moligand™, analytical standard, ≥98% |
Biochemical and Physiological Mechanisms | Apoptotic and anti-inflammatory agent. PPARγ inducer. Hesperidin ( Asc 1942 ) derivative. Shows anti-inflammatory and caspase/BCL-mediated apoptotic effects in vivo . Orally active. |
Shipped In | Normal |
Grade | analytical standard, Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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IUPAC Name | (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one |
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INCHI | InChI=1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/t14-/m0/s1 |
InChi Key | AIONOLUJZLIMTK-AWEZNQCLSA-N |
Canonical SMILES | COC1=C(C=C(C=C1)C2CC(=O)C3=C(C=C(C=C3O2)O)O)O |
Isomeric SMILES | COC1=C(C=C(C=C1)[C@@H]2CC(=O)C3=C(C=C(C=C3O2)O)O)O |
PubChem CID | 72281 |
Molecular Weight | 302.29 |
Reaxy-Rn | 309850 |
Enter Lot Number to search for COA:
Specific Rotation[α] | -4 ° (C=1.8, EtOH) |
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Melt Point(°C) | 232°C |
Reaxy-Rn | 309850 |
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Merck Index | 4670 |
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1. Chengyun He, Lu Bai, Daqun Liu, Benguo Liu. (2023) Interaction mechanism of okra (Abelmoschus esculentus L.) seed protein and flavonoids: Fluorescent and 3D-QSAR studies. Food Chemistry-X, 20 (17): (101023). [PMID:38144792] [10.1016/j.fochx.2023.101023] |
2. Mengsi Zhang, Lu Wang, Hao Jin, Nan Zhao, Yi Liu, Shijie Lan, Shuwei Liu, Hao Zhang. (2023) Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance. JOURNAL OF CONTROLLED RELEASE, 358 (612). [PMID:37196899] [10.1016/j.jconrel.2023.05.020] |
3. Chunru Wang, Junyao Li, Xiangsheng Han, Shuai Liu, Xintao Gao, Chuanlong Guo, Xiaochen Wu. (2022) Silk sericin stabilized proanthocyanidins for synergetic alleviation of ulcerative colitis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 220 (1021). [PMID:36007701] [10.1016/j.ijbiomac.2022.08.134] |
4. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] [10.1039/D1FO03816H] |
5. Kai Ni, Jia Guo, Bing Bu, Yan Pan, Jingjing Li, Lei Liu, Mingzhi Luo, Linhong Deng. (2021) Naringin as a plant-derived bitter tastant promotes proliferation of cultured human airway epithelial cells via activation of TAS2R signaling. PHYTOMEDICINE, 84 (153491). [PMID:33601237] [10.1016/j.phymed.2021.153491] |
6. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song. (2020) Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 239 (118519). [PMID:32480277] [10.1016/j.saa.2020.118519] |
7. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang. (2020) Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations. FOOD CHEMISTRY, 323 (126807). [PMID:32330646] [10.1016/j.foodchem.2020.126807] |
8. Mengying He, Ting Wu, Siyi Pan, Xiaoyun Xu. (2014) Antimicrobial mechanism of flavonoids against Escherichia coli ATCC 25922 by model membrane study. APPLIED SURFACE SCIENCE, 305 (515). [PMID:] [10.1016/j.apsusc.2014.03.125] |
1. Chengyun He, Lu Bai, Daqun Liu, Benguo Liu. (2023) Interaction mechanism of okra (Abelmoschus esculentus L.) seed protein and flavonoids: Fluorescent and 3D-QSAR studies. Food Chemistry-X, 20 (17): (101023). [PMID:38144792] [10.1016/j.fochx.2023.101023] |
2. Mengsi Zhang, Lu Wang, Hao Jin, Nan Zhao, Yi Liu, Shijie Lan, Shuwei Liu, Hao Zhang. (2023) Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance. JOURNAL OF CONTROLLED RELEASE, 358 (612). [PMID:37196899] [10.1016/j.jconrel.2023.05.020] |
3. Chunru Wang, Junyao Li, Xiangsheng Han, Shuai Liu, Xintao Gao, Chuanlong Guo, Xiaochen Wu. (2022) Silk sericin stabilized proanthocyanidins for synergetic alleviation of ulcerative colitis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 220 (1021). [PMID:36007701] [10.1016/j.ijbiomac.2022.08.134] |
4. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] [10.1039/D1FO03816H] |
5. Kai Ni, Jia Guo, Bing Bu, Yan Pan, Jingjing Li, Lei Liu, Mingzhi Luo, Linhong Deng. (2021) Naringin as a plant-derived bitter tastant promotes proliferation of cultured human airway epithelial cells via activation of TAS2R signaling. PHYTOMEDICINE, 84 (153491). [PMID:33601237] [10.1016/j.phymed.2021.153491] |
6. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song. (2020) Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 239 (118519). [PMID:32480277] [10.1016/j.saa.2020.118519] |
7. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang. (2020) Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations. FOOD CHEMISTRY, 323 (126807). [PMID:32330646] [10.1016/j.foodchem.2020.126807] |
8. Mengying He, Ting Wu, Siyi Pan, Xiaoyun Xu. (2014) Antimicrobial mechanism of flavonoids against Escherichia coli ATCC 25922 by model membrane study. APPLIED SURFACE SCIENCE, 305 (515). [PMID:] [10.1016/j.apsusc.2014.03.125] |