Inhibits 20-HETE production (IC 50 values are 18, 12 and 21 nM for CPY4A1, 4A2 and 4A3 respectively). Increases renal blood flow and inhibits cerebral ischemic damage in vivo. Crosses the blood-brain barrier.
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of CYP4F12
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
1.Lasker JM, Chen WB, Wolf I, Bloswick BP, Wilson PD, Powell PK. (2000) Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11.. J Biol Chem, 275 (6):(4118-26). [PMID:10660572][10.1021/op500134e]
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