HET-0016 - ≥98%, high purity , CAS No.339068-25-6, Inhibitor of CYP4F12

Item Number
H275645
Grouped product items
SKUSizeAvailabilityPrice Qty
H275645-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$53.90
H275645-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$187.90

Potent, selective 20-HETE synthase inhibitor

View related series
CYP4F12 Inhibitor

Basic Description

Synonyms339068-25-6 | HET0016 | HET-0016 | N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine | N'-(4-butyl-2-methylphenyl)-N-hydroxymethanimidamide | CHEMBL267865 | Methanimidamide, N-(4-butyl-2-methylphenyl)-N'-hydroxy- | N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamide | HMS
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsInhibits 20-HETE production (IC 50 values are 18, 12 and 21 nM for CPY4A1, 4A2 and 4A3 respectively). Increases renal blood flow and inhibits cerebral ischemic damage in vivo. Crosses the blood-brain barrier.
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of CYP4F12
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2C19 Tchem Cytochrome P450 2C19 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP4F12 Tbio Cytochrome P450 4F12 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP4F12 Tbio Cytochrome P450 4F12 (23 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP4F11 Tbio Cytochrome P450 4F11 (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP4Z1 Tchem Cytochrome P450 4Z1 (127 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name N'-(4-butyl-2-methylphenyl)-N-hydroxymethanimidamide
INCHI InChI=1S/C12H18N2O/c1-3-4-5-11-6-7-12(10(2)8-11)13-9-14-15/h6-9,15H,3-5H2,1-2H3,(H,13,14)
InChi Key LYNOGBKNFIHKLE-UHFFFAOYSA-N
Canonical SMILES CCCCC1=CC(=C(C=C1)N=CNO)C
Isomeric SMILES CCCCC1=CC(=C(C=C1)N=CNO)C
Alternate CAS 339068-25-6
PubChem CID 2727594
MeSH Entry Terms HET 0016;HET0016;N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine;N-hydroxy-N-4-butyl-2-methylphenylformamidine
Molecular Weight 206.3

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO to 25 mM

Related Documents

References

1. Lasker JM, Chen WB, Wolf I, Bloswick BP, Wilson PD, Powell PK.  (2000)  Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11..  J Biol Chem,  275  (6): (4118-26).  [PMID:10660572]

Solution Calculators