Basic Description

Synonyms	1-hexadecylpyridin-1-ium hydrate chloride \| Cetylpyridinium chloride (USP) \| D01062 \| HY-B1289 \| (1-Hexadecyl)pyridinium chloride monohydrate \| C21H40ClNO \| Cetylpyridinium chloride hydrate \| 1-Hexadecyl-1-pyridinium Chloride Hydrate \| AMY18060 \| Cetylpyr
Specifications & Purity	Ph.Eur.
Grade	Ph.Eur.
Product Description	Application Hexadecylpyridinium chloride is used as a component of cationic and mixed micelles and in nanoparticle and hydrogel compositions. Used for detergent-based extraction of membrane-associated enzymes such as alkaline phosphatase, and in extraction of chromium and palladium.

Associated Targets(Human)

HSPD1 Tbio 60 kDa heat shock protein, mitochondrial (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RAD52 Tchem DNA repair protein RAD52 homolog (0 Activities)

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)

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TST Tchem Thiosulfate sulfurtransferase (0 Activities)

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MC4R Tclin Melanocortin receptor 4 (0 Activities)

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OPRD1 Tclin Delta-type opioid receptor (0 Activities)

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Caco-2 (12174 Activities)

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

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OPRD1 Tclin Opioid receptors; mu & delta (1530 Activities)

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RAD52 Tchem DNA repair protein RAD52 homolog (856 Activities)

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HSPD1 Tbio HSP60/HSP10 (366 Activities)

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TST Tchem Thiosulfate sulfurtransferase (144 Activities)

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Associated Targets(non-human)

Mc4r Melanocortin receptor 4 (1205 Activities)

Discover Target: Mc4r

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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groL GroEL/GroES (1042 Activities)

Discover Target: groL

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groEL 60 kDa chaperonin (64 Activities)

Discover Target: groEL

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SARS-CoV-2 (38078 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-hexadecylpyridin-1-ium;chloride;hydrate
INCHI	InChI=1S/C21H38N.ClH.H2O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-22-20-17-15-18-21-22;;/h15,17-18,20-21H,2-14,16,19H2,1H3;1H;1H2/q+1;;/p-1
InChi Key	NFCRBQADEGXVDL-UHFFFAOYSA-M
Canonical SMILES	CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1.O.[Cl-]
Isomeric SMILES	CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1.O.[Cl-]
WGK Germany	3
RTECS	UU5075000
PubChem CID	22324
UN Number	2811
Molecular Weight	358
Beilstein	3578606
Reaxy-Rn	17134807

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Melt Point(°C)	81°C-86°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS09, GHS05, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H335:May cause respiratory irritation H301:Toxic if swallowed H318:Causes serious eye damage H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H330:Fatal if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P320:Specific treatment is urgent (see ... on this label). P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P332+P317:If skin irritation occurs: Get medical help. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	UU5075000
Reaxy-Rn	17134807
Merck Index	2032

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Xiaoyu Liu, Beike Wang, Maolin Chang, Xiaocen Zhang, Hao Zou, Zhen Zhang, Guangli Han. (2024) USP12 regulates ER stress-associated osteogenesis in human periodontal ligament cells under tension stress. CELLULAR SIGNALLING, 114 (111015). [PMID:38113977]
2. Xinyue Wang, Liuxu Sun, Xuan Qin, Jiayi You, Jing Zhang, Yang Xia. (2023) Enhanced Anti-inflammatory Capacity of the Conditioned Medium Derived from Periodontal Ligament Stem Cells Modified with an Iron-Based Nanodrug. Advanced Biology, (2300044). [PMID:37409394]
3. Chenqi Zhang, Xinshuang Gao, Hanbo Li, Yinglu Ji, Rui Cai, Zhijian Hu, Xiaochun Wu. (2023) Regulation of Chirality Transfer and Amplification from Chiral Cysteine to Gold Nanorod Assemblies using Nonchiral Surface Ligands. Advanced Optical Materials, 11 (18): (2202804). [PMID:]
4. Liang Wang, Qiushi Li, Haibo Yan, Guangjun Jiao, Hongliang Wang, Hai Chi, Hongming Zhou, Lu Chen, Yu Shan, Yunzhen Chen. (2022) Resveratrol Protects Osteoblasts Against Dexamethasone-Induced Cytotoxicity Through Activation of AMP-Activated Protein Kinase. Drug Design Development and Therapy, [PMID:33122889]
5. Yamin Lv, Zhenning Yan, Liyun Liu. (2023) Study on the interactions of tetradecylpyridinium dl-mandelic acid and cetylpyridinium dl-mandelic acid with some small biomolecules in aqueous solution. JOURNAL OF CHEMICAL THERMODYNAMICS, 176 (106912). [PMID:]
6. Fan Wang, Qinghua Yu, Jia Li, Junhao Jiang, Tao Deng, Chao Yu. (2022) Biomimetic macrophage membrane-coated gold-quantum dots with tumor microenvironment stimuli-responsive capability for tumor theranostic. Materials Today Bio, 16 (100359). [PMID:35937575]
7. Wang Ningning, Qi Desheng, Liu Lu, Zhu Yanlin, Liu Hong, Zhu Song. (2022) Fabrication of In Situ Grown Hydroxyapatite Nanoparticles Modified Porous Polyetheretherketone Matrix Composites to Promote Osteointegration and Enhance Bone Repair. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35295654]
8. Yi Chen, Haojing Yin, Debabrata Sikdar, Linglin Yan, Zheng Zhou, Jiacen Sun, Chuan Wang. (2021) Gold Nanopolyhedron-Based Superlattice Sheets as Flexible Surface-Enhanced Raman Scattering Sensors for Detection of 4-Aminothiophenol. ACS Applied Nano Materials, 4 (11): (12498–12505). [PMID:]
9. Chuan Fu, Yikun Jiang, Xiaoyu Yang, Yu Wang, Wei Ji, Guoliang Jia. (2021) Mussel-Inspired Gold Nanoparticle and PLGA/L-Lysine-g-Graphene Oxide Composite Scaffolds for Bone Defect Repair. International Journal of Nanomedicine, 16 ( 6693–6718). [PMID:34621123]
10. Zhong-shui Xie, Rong-rong Xing, Xuan Chen, Shuang Hu, Xiao-hong Bai. (2021) Simultaneous preconcentration of both polar and non-polar Q-markers of flavonoids in traditional Chinese medicine by reverse micellar floating solidification liquid-phase microextraction. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, [PMID:]
11. Liu Mingyang, Du Xuejun, Xu Ke, Yan Binwei, Fan Zaibi, Gao Zideng, Ren Xueqin. (2021) A cationic quantum dot-based ratiometric fluorescent probe to visually detect berberine hydrochloride in human blood serums. Journal of Analytical Science and Technology, 12 (1): (1-9). [PMID:]
12. Zhenning Yan, Xingxing Cao, Meng Sun, Lulu Zhang. (2021) Physicochemical study on molecular interactions in ternary aqueous solutions of the pharmaceutically active ionic liquid cetylpyridinium salicylate and amino acid/glycylglycine at different temperatures. JOURNAL OF MOLECULAR LIQUIDS, 326 (115258). [PMID:]
13. Zhao-chan Liu, Shu-mei Zhang, Run-qin Wang, Xuan Chen, Shuang Hu, Xiao-hong Bai. (2019) Comparison of three-phase hollow fiber liquid-phase microextraction based on reverse micelle with conventional two-phase hollow fiber liquid-phase microextraction and their applications for analysis of cinnamic acids in traditional Chinese medicines. JOURNAL OF SEPARATION SCIENCE, 42 (18): (2977-2984). [PMID:31273922]
14. Xianhua He, Yi Deng, Yue Yu, Hao Lyu, Li Liao. (2019) Drug-loaded/grafted peptide-modified porous PEEK to promote bone tissue repair and eliminate bacteria. COLLOIDS AND SURFACES B-BIOINTERFACES, 181 (767). [PMID:31234064]
15. Chao Wang, Liuyi Hu, Kang Zhao, Anping Deng, Jianguo Li. (2018) Multiple signal amplification electrochemiluminescent immunoassay for Sudan I using gold nanorods functionalized graphene oxide and palladium/aurum core-shell nanocrystallines as labels. ELECTROCHIMICA ACTA, 278 (352). [PMID:]
16. Ling Ouyang, Yi Deng, Lei Yang, Xiuyuan Shi, Taosheng Dong, Youyi Tai, Weizhong Yang, Zhi-Gang Chen. (2018) Graphene-Oxide-Decorated Microporous Polyetheretherketone with Superior Antibacterial Capability and In Vitro Osteogenesis for Orthopedic Implant. MACROMOLECULAR BIOSCIENCE, 18 (6): (1800036). [PMID:29719124]
17. Jiao Ma, Chengcheng Yang, Shu Zhu, Jinyi Song, Yingzi Fu. (2018) A new nanomatrix based on functionalized fullerene and porous bimetallic nanoparticles for electrochemical chiral sensing. NEW JOURNAL OF CHEMISTRY, 42 (12): (9801-9807). [PMID:]
18. An Xiaojiao, Kang Yong, Li Guishui. (2018) Flocculation of gelatinized starch: Flocculation performance and floc characterization. KOREAN JOURNAL OF CHEMICAL ENGINEERING, 35 (7): (1500-1508). [PMID:]
19. Wang Xiangyan, Sun Duanping, Tong Yanli, Zhong Yongsheng, Chen Zuanguang. (2017) A voltammetric aptamer-based thrombin biosensor exploiting signal amplification via synergetic catalysis by DNAzyme and enzyme decorated AuPd nanoparticles on a poly(o-phenylenediamine) support. MICROCHIMICA ACTA, 184 (6): (1791-1799). [PMID:]
20. Min Su, Haiyun Liu, Shenguang Ge, Na Ren, Longhua Ding, Jinghua Yu, Xianrang Song. (2016) An electrochemiluminescence lab-on-paper device for sensitive detection of two antigens at the MCF-7 cell surface based on porous bimetallic AuPd nanoparticles. RSC Advances, 6 (20): (16500-16506). [PMID:]
21. Wenju Xu, Huayu Yi, Yali Yuan, Pei Jing, Yaqin Chai, Ruo Yuan, George S. Wilson. (2015) An electrochemical aptasensor for thrombin using synergetic catalysis of enzyme and porous Au@Pd core–shell nanostructures for signal amplification. BIOSENSORS & BIOELECTRONICS, 64 (423). [PMID:25280342]
22. Jie-Ning Zheng, Li-Li He, Fang-Yi Chen, Ai-Jun Wang, Meng-Wei Xue, Jiu-Ju Feng. (2014) A facile general strategy for synthesis of palladium-based bimetallic alloyed nanodendrites with enhanced electrocatalytic performance for methanol and ethylene glycol oxidation. Journal of Materials Chemistry A, 2 (32): (12899-12906). [PMID:]

References

1. Kwang Sik Suh,Young Soon Lee,Eun Mi Choi. (2013-10-12) The protective effects of Achyranthes bidentata root extract on the antimycin A induced damage of osteoblastic MC3T3-E1 cells.. Cytotechnology, 66 ((6)): (925-935). [PMID:24113920]
2. Xiaoyu Liu, Beike Wang, Maolin Chang, Xiaocen Zhang, Hao Zou, Zhen Zhang, Guangli Han. (2024) USP12 regulates ER stress-associated osteogenesis in human periodontal ligament cells under tension stress. CELLULAR SIGNALLING, 114 (111015). [PMID:38113977]
3. Xinyue Wang, Liuxu Sun, Xuan Qin, Jiayi You, Jing Zhang, Yang Xia. (2023) Enhanced Anti-inflammatory Capacity of the Conditioned Medium Derived from Periodontal Ligament Stem Cells Modified with an Iron-Based Nanodrug. Advanced Biology, (2300044). [PMID:37409394]
4. Chenqi Zhang, Xinshuang Gao, Hanbo Li, Yinglu Ji, Rui Cai, Zhijian Hu, Xiaochun Wu. (2023) Regulation of Chirality Transfer and Amplification from Chiral Cysteine to Gold Nanorod Assemblies using Nonchiral Surface Ligands. Advanced Optical Materials, 11 (18): (2202804). [PMID:]
5. Liang Wang, Qiushi Li, Haibo Yan, Guangjun Jiao, Hongliang Wang, Hai Chi, Hongming Zhou, Lu Chen, Yu Shan, Yunzhen Chen. (2022) Resveratrol Protects Osteoblasts Against Dexamethasone-Induced Cytotoxicity Through Activation of AMP-Activated Protein Kinase. Drug Design Development and Therapy, [PMID:33122889]
6. Yamin Lv, Zhenning Yan, Liyun Liu. (2023) Study on the interactions of tetradecylpyridinium dl-mandelic acid and cetylpyridinium dl-mandelic acid with some small biomolecules in aqueous solution. JOURNAL OF CHEMICAL THERMODYNAMICS, 176 (106912). [PMID:]
7. Fan Wang, Qinghua Yu, Jia Li, Junhao Jiang, Tao Deng, Chao Yu. (2022) Biomimetic macrophage membrane-coated gold-quantum dots with tumor microenvironment stimuli-responsive capability for tumor theranostic. Materials Today Bio, 16 (100359). [PMID:35937575]
8. Wang Ningning, Qi Desheng, Liu Lu, Zhu Yanlin, Liu Hong, Zhu Song. (2022) Fabrication of In Situ Grown Hydroxyapatite Nanoparticles Modified Porous Polyetheretherketone Matrix Composites to Promote Osteointegration and Enhance Bone Repair. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35295654]
9. Yi Chen, Haojing Yin, Debabrata Sikdar, Linglin Yan, Zheng Zhou, Jiacen Sun, Chuan Wang. (2021) Gold Nanopolyhedron-Based Superlattice Sheets as Flexible Surface-Enhanced Raman Scattering Sensors for Detection of 4-Aminothiophenol. ACS Applied Nano Materials, 4 (11): (12498–12505). [PMID:]
10. Chuan Fu, Yikun Jiang, Xiaoyu Yang, Yu Wang, Wei Ji, Guoliang Jia. (2021) Mussel-Inspired Gold Nanoparticle and PLGA/L-Lysine-g-Graphene Oxide Composite Scaffolds for Bone Defect Repair. International Journal of Nanomedicine, 16 ( 6693–6718). [PMID:34621123]
11. Zhong-shui Xie, Rong-rong Xing, Xuan Chen, Shuang Hu, Xiao-hong Bai. (2021) Simultaneous preconcentration of both polar and non-polar Q-markers of flavonoids in traditional Chinese medicine by reverse micellar floating solidification liquid-phase microextraction. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, [PMID:]
12. Liu Mingyang, Du Xuejun, Xu Ke, Yan Binwei, Fan Zaibi, Gao Zideng, Ren Xueqin. (2021) A cationic quantum dot-based ratiometric fluorescent probe to visually detect berberine hydrochloride in human blood serums. Journal of Analytical Science and Technology, 12 (1): (1-9). [PMID:]
13. Zhenning Yan, Xingxing Cao, Meng Sun, Lulu Zhang. (2021) Physicochemical study on molecular interactions in ternary aqueous solutions of the pharmaceutically active ionic liquid cetylpyridinium salicylate and amino acid/glycylglycine at different temperatures. JOURNAL OF MOLECULAR LIQUIDS, 326 (115258). [PMID:]
14. Zhao-chan Liu, Shu-mei Zhang, Run-qin Wang, Xuan Chen, Shuang Hu, Xiao-hong Bai. (2019) Comparison of three-phase hollow fiber liquid-phase microextraction based on reverse micelle with conventional two-phase hollow fiber liquid-phase microextraction and their applications for analysis of cinnamic acids in traditional Chinese medicines. JOURNAL OF SEPARATION SCIENCE, 42 (18): (2977-2984). [PMID:31273922]
15. Xianhua He, Yi Deng, Yue Yu, Hao Lyu, Li Liao. (2019) Drug-loaded/grafted peptide-modified porous PEEK to promote bone tissue repair and eliminate bacteria. COLLOIDS AND SURFACES B-BIOINTERFACES, 181 (767). [PMID:31234064]
16. Chao Wang, Liuyi Hu, Kang Zhao, Anping Deng, Jianguo Li. (2018) Multiple signal amplification electrochemiluminescent immunoassay for Sudan I using gold nanorods functionalized graphene oxide and palladium/aurum core-shell nanocrystallines as labels. ELECTROCHIMICA ACTA, 278 (352). [PMID:]
17. Ling Ouyang, Yi Deng, Lei Yang, Xiuyuan Shi, Taosheng Dong, Youyi Tai, Weizhong Yang, Zhi-Gang Chen. (2018) Graphene-Oxide-Decorated Microporous Polyetheretherketone with Superior Antibacterial Capability and In Vitro Osteogenesis for Orthopedic Implant. MACROMOLECULAR BIOSCIENCE, 18 (6): (1800036). [PMID:29719124]
18. Jiao Ma, Chengcheng Yang, Shu Zhu, Jinyi Song, Yingzi Fu. (2018) A new nanomatrix based on functionalized fullerene and porous bimetallic nanoparticles for electrochemical chiral sensing. NEW JOURNAL OF CHEMISTRY, 42 (12): (9801-9807). [PMID:]
19. An Xiaojiao, Kang Yong, Li Guishui. (2018) Flocculation of gelatinized starch: Flocculation performance and floc characterization. KOREAN JOURNAL OF CHEMICAL ENGINEERING, 35 (7): (1500-1508). [PMID:]
20. Wang Xiangyan, Sun Duanping, Tong Yanli, Zhong Yongsheng, Chen Zuanguang. (2017) A voltammetric aptamer-based thrombin biosensor exploiting signal amplification via synergetic catalysis by DNAzyme and enzyme decorated AuPd nanoparticles on a poly(o-phenylenediamine) support. MICROCHIMICA ACTA, 184 (6): (1791-1799). [PMID:]
21. Min Su, Haiyun Liu, Shenguang Ge, Na Ren, Longhua Ding, Jinghua Yu, Xianrang Song. (2016) An electrochemiluminescence lab-on-paper device for sensitive detection of two antigens at the MCF-7 cell surface based on porous bimetallic AuPd nanoparticles. RSC Advances, 6 (20): (16500-16506). [PMID:]
22. Wenju Xu, Huayu Yi, Yali Yuan, Pei Jing, Yaqin Chai, Ruo Yuan, George S. Wilson. (2015) An electrochemical aptasensor for thrombin using synergetic catalysis of enzyme and porous Au@Pd core–shell nanostructures for signal amplification. BIOSENSORS & BIOELECTRONICS, 64 (423). [PMID:25280342]
23. Jie-Ning Zheng, Li-Li He, Fang-Yi Chen, Ai-Jun Wang, Meng-Wei Xue, Jiu-Ju Feng. (2014) A facile general strategy for synthesis of palladium-based bimetallic alloyed nanodendrites with enhanced electrocatalytic performance for methanol and ethylene glycol oxidation. Journal of Materials Chemistry A, 2 (32): (12899-12906). [PMID:]

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Hexadecylpyridinium chloride monohydrate - tested according to Ph. Eur., high purity , CAS No.6004-24-6