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hGCGR Antagonist - >95%, high purity , CAS No.438618-32-7, Antagonist of glucagon receptor
a potent and selective cell-permeable Glukagon receptor antagonist
Basic Description Synonyms MFCD01920208 | NCGC00340210-02 | AKOS017343007 | N-[3-cyano-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-2-ethylbutanamide | hGCGR Antagonist | DTXSID70347212 | GTPL1148 | STK315567 | BDBM50161494 | Benzothiophene-3-carbonitrile, 4,5,6, Specifications & Purity Moligand™, ≥95% Storage Temp Store at 2-8°C Shipped In Wet ice Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of glucagon receptor Product Description Glukagon Receptor Antagonist I is a potent and selective cell-permeable thienyl-amide compound that acts as a competitive antagonist of the Glukagon receptor. Exhibits binding to hGCGR with high affinity and prevents its interaction with Glukagon (IC|50|= 181 nM, K|DB|= 81 nM, and pA2 = 7.1 in membranes prepared from CHO-hGCGR). Also suppresses Glukagon-induced glycogenolysis in human primary hepatocytes and in mice (50 mg/kg, ip).
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N-[3-cyano-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-2-ethylbutanamide INCHI InChI=1S/C20H30N2OS/c1-6-13(7-2)18(23)22-19-16(12-21)15-10-9-14(11-17(15)24-19)20(4,5)8-3/h13-14H,6-11H2,1-5H3,(H,22,23) InChi Key SWIBDWBSJSJQHL-UHFFFAOYSA-N Canonical SMILES CCC(CC)C(=O)NC1=C(C2=C(S1)CC(CC2)C(C)(C)CC)C#N Isomeric SMILES CCC(CC)C(=O)NC1=C(C2=C(S1)CC(CC2)C(C)(C)CC)C#N PubChem CID 619101 Molecular Weight 346.5
Chemical and Physical Properties Solubility Soluble in DMSO (5 mg/ml), and methanol (5 mg/ml). Refractive Index n20D1.54 (Predicted) Boil Point(°C) 517.78° C at 760 mmHg (Predicted) Melt Point(°C) 212.68° C (Predicted)
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