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H421649-1ml

1ml

Available within 4-8 weeks(?)

$241.90

Basic Description

Synonyms	Hispidulin \| 1447-88-7 \| Dinatin \| Scutellarein 6-methyl ether \| 4',5,7-Trihydroxy-6-methoxyflavone \| 4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)-6-METHOXY- \| Salvitin \| 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one \| 6-O-Methylapigenin \| NSC 12
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Partial positive allosteric modulator at the benzodiazepine receptor (IC50= 1.3μM for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressingα1-,α2-,α3-,α5- orα6-β2γ2S GABAAreceptors
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Hispidulin has been used as a calibration standard: in high-performance liquid chromatography (HPLC) for quantification of Clerodendrum petasites flavonoids in liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS) analysis in reverse-phase high-performance liquid chromatography with a diode-array detector (HPLC-DAD) and high-performance thin-layer chromatography (HPTLC)

Associated Targets(Human)

GFER Tchem FAD-linked sulfhydryl oxidase ALR (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

Discover Target: ADORA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTH1R Tclin Parathyroid hormone receptor (47172 Activities)

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ADORA2A Tclin Adenosine A2a receptor (16305 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADORA3 Tchem Adenosine A3 receptor (15931 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLB Tchem DNA polymerase beta (23632 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PIM1 Tchem Serine/threonine-protein kinase PIM1 (9629 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A1 Tchem Cytochrome P450 1A1 (1169 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC2A1 Tchem Glucose transporter (14755 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FLT3 Tclin Tyrosine-protein kinase receptor FLT3 (13481 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

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ATM Tchem Serine-protein kinase ATM (4198 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MKNK2 Tchem MAP kinase signal-integrating kinase 2 (3518 Activities)

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A498 (42825 Activities)

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ACHN (49357 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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HT-1080 (3966 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MCF7 (126967 Activities)

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MOLT-4 (49676 Activities)

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Panel NCI-60 (60 carcinoma cell lines) (1088 Activities)

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OVCAR-3 (48710 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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PC-3 (62116 Activities)

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RPMI-8226 (44974 Activities)

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RXF 393 (41971 Activities)

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SF-295 (48000 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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TK-10 (45540 Activities)

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U-251 (51189 Activities)

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UACC-257 (46019 Activities)

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UACC-62 (47335 Activities)

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UO-31 (46270 Activities)

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ZR-75-1 (953 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI/ADR-RES (33767 Activities)

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Associated Targets(non-human)

NA Neuraminidase (1107 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DPP4 Dipeptidyl peptidase IV (11 Activities)

Discover Target: DPP4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Proteus vulgaris (5823 Activities)

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Bacillus subtilis (32866 Activities)

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Mycobacterium tuberculosis (203094 Activities)

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Plasmodium falciparum (966862 Activities)

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Hepatitis C virus (23859 Activities)

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Influenza A virus (11224 Activities)

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MDCK (10148 Activities)

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P388 (20296 Activities)

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ht1 Hexose transporter 1 (14071 Activities)

Discover Target: ht1

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Avian myoblastosis virus polyprotein II (68 Activities)

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Luciferin 4-monooxygenase (66902 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cdk5 Cell division protein kinase 5 (15 Activities)

Discover Target: Cdk5

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Plasma (328 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NS1 Nonstructural protein 1 (33327 Activities)

Discover Target: NS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Gabrp GABA-A receptor; anion channel (5731 Activities)

Discover Target: Gabrp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxychromen-4-one
INCHI	InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3
InChi Key	IHFBPDAQLQOCBX-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C2=C(C=C1O)OC(=CC2=O)C3=CC=C(C=C3)O)O
Isomeric SMILES	COC1=C(C2=C(C=C1O)OC(=CC2=O)C3=CC=C(C=C3)O)O
WGK Germany	3
RTECS	DJ2996000
PubChem CID	5281628
Molecular Weight	300.26

Certificates

Certificate of Analysis(COA)

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Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3
RTECS	DJ2996000

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Zhihua Chen, Guofeng Zhu, Chunpeng Sheng, Jianwei Lei, Sihui Song, Jianming Zhu. (2022) Hispidulin Enhances Temozolomide (TMZ)-Induced Cytotoxicity against Malignant Glioma Cells In Vitro by Inhibiting Autophagy. Computational Intelligence and Neuroscience, 2022 (5266770). [PMID:35800695] [10.1155/2022/5266770]
2. Xiaoli Wang, Jichen Yang, Huan Li, Se Shi, Xin Peng. (2022) Mechanistic study and synergistic effect on inhibition of α-amylase by structurally similar flavonoids. JOURNAL OF MOLECULAR LIQUIDS, 360 (119485). [PMID:] [10.1016/j.molliq.2022.119485]
3. Li Lv, Wenhui Zhang, Tingting Li, Lifeng Jiang, Xinyan Lu, Jie Lin. (2020) Hispidulin exhibits potent anticancer activity in vitro and in vivo through activating ER stress in non‑small‑cell lung cancer cells. ONCOLOGY REPORTS, 43 (6): (1995-2003). [PMID:32236602] [10.3892/or.2020.7568]

References

1. Zhihua Chen, Guofeng Zhu, Chunpeng Sheng, Jianwei Lei, Sihui Song, Jianming Zhu. (2022) Hispidulin Enhances Temozolomide (TMZ)-Induced Cytotoxicity against Malignant Glioma Cells In Vitro by Inhibiting Autophagy. Computational Intelligence and Neuroscience, 2022 (5266770). [PMID:35800695] [10.1155/2022/5266770]
2. Xiaoli Wang, Jichen Yang, Huan Li, Se Shi, Xin Peng. (2022) Mechanistic study and synergistic effect on inhibition of α-amylase by structurally similar flavonoids. JOURNAL OF MOLECULAR LIQUIDS, 360 (119485). [PMID:] [10.1016/j.molliq.2022.119485]
3. Li Lv, Wenhui Zhang, Tingting Li, Lifeng Jiang, Xinyan Lu, Jie Lin. (2020) Hispidulin exhibits potent anticancer activity in vitro and in vivo through activating ER stress in non‑small‑cell lung cancer cells. ONCOLOGY REPORTS, 43 (6): (1995-2003). [PMID:32236602] [10.3892/or.2020.7568]

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Hispidulin - 10mM in DMSO, high purity , CAS No.1447-88-7

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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