Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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H424422-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $162.90 |
Potent vasodilator and endogenous histamine receptor agonist.
Synonyms | histamine | 51-45-6 | 2-(1H-imidazol-5-yl)ethanamine | Ergamine | Ergotidine | 1H-Imidazole-4-ethanamine | 2-(4-Imidazolyl)ethylamine | 5-Imidazoleethylamine | Eramin | Theramine | 2-(1H-Imidazol-4-yl)ethanamine | Free histamine | 65592-96-3 | beta-Aminoethylimidazole | 2-Imidazol-4 |
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Specifications & Purity | Moligand™, 10mM in DMSO |
Biochemical and Physiological Mechanisms | Histamine, Free Base is a potent vasodilator found in normal tissues and blood. This compound is formed by the decarboxylation of L-histidine and activates NOS (nitric oxide synthase), resulting in the release of nitric oxide. Activation of Histamine H1 R |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | A compound that activates NOS which results in the release of NO. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-(1H-imidazol-5-yl)ethanamine |
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INCHI | InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8) |
InChi Key | NTYJJOPFIAHURM-UHFFFAOYSA-N |
Canonical SMILES | C1=C(NC=N1)CCN |
Isomeric SMILES | C1=C(NC=N1)CCN |
WGK Germany | 3 |
RTECS | MS1050000 |
PubChem CID | 774 |
UN Number | 2811 |
Molecular Weight | 111.15 |
Beilstein | 2012 |
Enter Lot Number to search for COA:
Sensitivity | Hygroscopic & Heat & Light sensitive |
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Boil Point(°C) | 167°C |
Melt Point(°C) | 83-84°C |
Pictogram(s) | GHS06, GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately. |
WGK Germany | 3 |
RTECS | MS1050000 |
1. Peng Nie, Xiang Gao, Xuefei Yang, Yang Zhang, Haijie Lu, Heng Wang, Zhi Zheng, Yizhong Shen. (2024) AIE fluorogen-based oxidase-like fluorescence nanozyme-integrated smartphone for monitoring the freshness authenticity of soy products. FOOD CHEMISTRY, 439 (28): (138122). [PMID:38070231] [10.1016/j.foodchem.2023.138122] |
2. Yiting Xu, Xiaobo Yu, Meiling Chen, Yi Sun, Wei Zhang, Yajin Fang, Lanyun Fang, Haining Na, Fei Liu, Jin Zhu. (2023) Dual responsive cellulose-based fluorescent material fabricated in a CO2 switchable solvent for multifunctional applications. CHEMICAL ENGINEERING JOURNAL, 477 (147272). [PMID:12871148] [10.1016/j.cej.2023.147272] |
3. Junjun Wang, Yue Tang, Jia Zheng, Zhengmin Xie, Jianli Zhou, Yuangen Wu. (2024) DNAzyme-based and smartphone-assisted colorimetric biosensor for ultrasensitive and highly selective detection of histamine in meats. FOOD CHEMISTRY, 435 (13): (137526). [PMID:37742463] [10.1016/j.foodchem.2023.137526] |
4. Zekun Shi, Yongning Wu, Xue Zhang, Yanyan Gao, Luqin Qiao, Qin Hou, Minglin Wang. (2023) Highly sensitive and selective colorimetric and fluorescent dual-readout assay for the analysis of spermine, spermidine and cysteine. DYES AND PIGMENTS, 220 (111659). [PMID:] [10.1016/j.dyepig.2023.111659] |
5. Xiang Gao, Peng Nie, Peiran Li, Zhi Zheng, Jieshun Cheng, Ying Gu, Yizhong Shen. (2023) Silver metallization-triggered liposome-embedded AIE fluorophore for dual-mode detection of biogenic amines to fight food freshness fraud. FOOD CHEMISTRY, 429 (136961). [PMID:37499507] [10.1016/j.foodchem.2023.136961] |
6. Xu Rui-Qi, Ma Ling, Chen Timson, Zhang Wei-Xiong, Chang Kuan, Wang Jing. (2023) Sophorolipid inhibits histamine-induced itch by decreasing PLC/IP3R signaling pathway activation and modulating TRPV1 activity. Scientific Reports, 13 (1): (1-13). [PMID:37198299] [10.1038/s41598-023-35158-9] |
7. Nuo Duan, Kexin Ren, Mingqian Song, Xinyue Zhang, Zhouping Wang, Fei Jia, Shijia Wu. (2023) A dual-donor FRET based aptamer sensor for simultaneous determination of histamine and tyramine in fishes. MICROCHEMICAL JOURNAL, 191 (108801). [PMID:] [10.1016/j.microc.2023.108801] |
8. Baihui Wang, Huan Jiang, Ruyi Tang, Yaoyu Tan, Xuemin Xia, Xia Zhang. (2023) Construction of histamine aptamer sensor based on Au NPs nanozyme for ultrasensitive SERS detection of histamine. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 120 (105337). [PMID:] [10.1016/j.jfca.2023.105337] |
9. Xiaoqi Lu, Siyu Ji, Zhengbing Ren, Shangkun Jiang, Qian Yu, Jiaqi Guo, Alan X. Wang, Xianming Kong. (2023) Rapid, convenient, and ultrasensitive point-of-care sensing of histamine from fish: A Portable chromatographic platform based on derivatization reaction. JOURNAL OF CHROMATOGRAPHY A, 1696 (463953). [PMID:37037052] [10.1016/j.chroma.2023.463953] |
10. Ruixue Wang, Zhongwen Li, Xiaosen Li, Peiwen Guo, Haibo Wang, Xuan Guo, Jinyi Zhong. (2023) Plasma jet decontamination of sulfur mustard and its analogues in water by oxidation effect. Journal of Water Process Engineering, 53 (103647). [PMID:] [10.1016/j.jwpe.2023.103647] |
11. Si Lin, Hou Juying, Lv Wei, Hou Qin, Xu Zhixiang, Ai Shiyun. (2023) An intelligent fluorescence platform based on lignocellulose components and fluorescein for food freshness monitoring. Biomass Conversion and Biorefinery, (1-11). [PMID:] [10.1007/s13399-023-03879-6] |
12. Xin Huang, Rui Wang, Yikai Wang, Changbao Chen, Shuying Liu. (2023) Investigation on property differences of ginseng and American ginseng by spatial metabolomics of neurochemicals with desorption electrospray ionization mass spectrometry imaging. JOURNAL OF ETHNOPHARMACOLOGY, 303 (116006). [PMID:36516905] [10.1016/j.jep.2022.116006] |
13. Wang Tingting, Chen Yihui, Hou Chunyan, Qiao Xiaoqiang. (2023) PEG-modified halloysite as a hydrophilic interaction and cation exchange mixed-mode sorbent for solid-phase extraction of biogenic amines in fish samples. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (18): (4265-4275). [PMID:36422664] [10.1007/s00216-022-04441-5] |
14. Bin Zhou, Runlin Yang, Muhammad Sohail, Xiaoxue Kong, Xing Zhang, Ninghua Fu, Bingzhi Li. (2023) CRISPR/Cas14 provides a promising platform in facile and versatile aptasensing with improved sensitivity. TALANTA, 254 (124120). [PMID:36463799] [10.1016/j.talanta.2022.124120] |
15. Xun Zhou, Yongxiang Wu, Yao Jiang, Chen Li, Longping Xu, Peng Cui, Xinsong She. (2023) Integrated one–dimensional CuO–nanowire arrays/Cu–foam nanoarchitecture for ultrahigh sensitive and non–enzymatic electrochemical determination of histamine levels in different–bacteria fermented mandarin fish. FOOD CHEMISTRY, 405 (134776). [PMID:36347206] [10.1016/j.foodchem.2022.134776] |
16. Xiaofu Wang, Yunsong Zhao, Sufang Zhang, Xinping Lin, Huipeng Liang, Yingxi Chen, Chaofan Ji. (2022) Heterologous Expression of the Lactobacillus sakei Multiple Copper Oxidase to Degrade Histamine and Tyramine at Different Environmental Conditions. Foods, 11 (20): (3306). [PMID:37431050] [10.3390/foods11203306] |
17. Yuqing Qin, Weikang Ke, Aroosha Faheem, Yueyun Ye, Yonggang Hu. (2023) A rapid and naked-eye on-site monitoring of biogenic amines in foods spoilage. FOOD CHEMISTRY, 404 (134581). [PMID:36252369] [10.1016/j.foodchem.2022.134581] |
18. Jing Han, Xinping Lin, Huipeng Liang, Sufang Zhang, Beiwei Zhu, Chaofan Ji. (2022) Improving the safety and quality of Roucha using amine-degrading lactic acid bacteria starters. FOOD RESEARCH INTERNATIONAL, 161 (111918). [PMID:36192920] [10.1016/j.foodres.2022.111918] |
19. Jianfeng Yan, Quanbin Fu, Shikai Zhang, Yu Liu, Xianbao Shi, Juying Hou, Junling Duan, Shiyun Ai. (2022) A sensitive ratiometric fluorescent sensor based on carbon dots and CdTe quantum dots for visual detection of biogenic amines in food samples. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 282 (121706). [PMID:35933782] [10.1016/j.saa.2022.121706] |
20. Huang Wenwen, Zhou Xiaoying. (2022) Anti-histamine effects of dipotassium glycyrrhizinate on lung fibroblasts, implicating its therapeutic mechanism for pulmonary fibrosis. JOURNAL OF PHARMACY AND PHARMACOLOGY, 74 (9): (1241-1250). [PMID:35788858] [10.1093/jpp/rgac030] |
21. Yujuan Qin, Pengcheng Huang, Fang-Ying Wu. (2022) Histamine-responsive dye-incorporated carbon dots for visual monitoring of food spoilage. SENSORS AND ACTUATORS B-CHEMICAL, 365 (131911). [PMID:] [10.1016/j.snb.2022.131911] |
22. Sihan Zhang, Qinzhen Fan, Jiaqi Guo, Xianhe Jiao, Xianming Kong, Qian Yu. (2022) Surface-enhanced Raman spectroscopy tandem with derivatized thin-layer chromatography for ultra-sensitive on-site detection of histamine from fish. FOOD CONTROL, 138 (108987). [PMID:] [10.1016/j.foodcont.2022.108987] |
23. Xu Xu, Jiaxin Gao, Di Cao, Xiang Li, Xin Zhao, Shuang Yue, Lei Zhang. (2022) Designed 3D N-doped magnetic porous carbon spheres for sensitive monitoring of biogenic amine by simultaneous microwave-assisted derivatization and magnetic-solid phase extraction. JOURNAL OF CHROMATOGRAPHY A, 1667 (462882). [PMID:35149412] [10.1016/j.chroma.2022.462882] |
24. Nuo Duan, Mingqian Song, Weiyu Mi, Zhouping Wang, Shijia Wu. (2021) Effectively Selecting Aptamers for Targeting Aromatic Biogenic Amines and Their Application in Aptasensing Establishment. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 69 (48): (14671–14679). [PMID:34809428] [10.1021/acs.jafc.1c05934] |
25. Nuo Duan, Changxin Li, Xiaoyin Zhu, Shuo Qi, Zhouping Wang, Shijia Wu. (2022) Simultaneous coupled with Separate SELEX for heterocyclic biogenic amine-specific aptamers screening and their application in establishment of an effective aptasensor. SENSORS AND ACTUATORS B-CHEMICAL, 352 (130985). [PMID:] [10.1016/j.snb.2021.130985] |
26. Xinxiu Ma, Jingran Bi, Xinyu Li, Gongliang Zhang, Hongshun Hao, Hongman Hou. (2021) Contribution of Microorganisms to Biogenic Amine Accumulation during Fish Sauce Fermentation and Screening of Novel Starters. Foods, 10 (11): (2572). [PMID:34828853] [10.3390/foods10112572] |
27. Yingnan Liu, Yaqing Xiao, Minghui Shang, Yuting Zhuang, Li Wang. (2022) Smart fluorescent tag based on amine response for non-contact and visual monitoring of seafood freshness. CHEMICAL ENGINEERING JOURNAL, 428 (132647). [PMID:] [10.1016/j.cej.2021.132647] |
28. Xueqing Gao, Xiaowen Gu, Qi Min, Yueyue Wei, Chunyuan Tian, Xuming Zhuang, Feng Luan. (2022) Encapsulating Ru(bpy)32+ in an infinite coordination polymer network: Towards a solid-state electrochemiluminescence sensing platform for histamine to evaluate fish product quality. FOOD CHEMISTRY, 368 (130852). [PMID:34419792] [10.1016/j.foodchem.2021.130852] |
29. Jiawei Li, Zhengfan Shui, Liang Dong, Lian Shen, Dong Zhao, Huibo Luo, Yi Ma, Changjun Hou, Danqun Huo. (2020) A novel acid-sensitive quantum dot sensor array for the identification of Chinese baijiu. Analytical Methods, 12 (39): (4789-4797). [PMID:32955054] [10.1039/D0AY01454K] |
30. Huang Lin, Wang Lin, Hu Xiaomeng, Chen Sen, Tao Yunwen, Su Haiyang, Yang Jing, Xu Wei, Vedarethinam Vadanasundari, Wu Shu, Liu Bin, Wan Xinze, Lou Jiatao, Wang Qian, Qian Kun. (2020) Machine learning of serum metabolic patterns encodes early-stage lung adenocarcinoma. Nature Communications, 11 (1): (1-11). [PMID:32678093] [10.1038/s41467-020-17347-6] |
31. Liu Song, Yang Huang, Marie-Jia Gou, Jacques Crommen, Zhengjin Jiang, Yifan Feng. (2020) Method development and validation for the determination of biogenic amines in soy sauce using supercritical fluid chromatography coupled with single quadrupole mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 43 (13): (2728-2736). [PMID:32281256] [10.1002/jssc.202000030] |
32. Hailong Sun, Shuangping Liu, Jieqi Mao, Ziwei Yu, Zhijie Lin, Jian Mao. (2020) New insights into the impacts of huangjiu compontents on intoxication. FOOD CHEMISTRY, 317 (126420). [PMID:32101783] [10.1016/j.foodchem.2020.126420] |
33. Enming Miao, Nazhen Zhang, Shiwei Lu, Yufeng Hu, Lin Fu, Hao Zhou, Jingjing Zhan, Minghuo Wu. (2020) Solid phase “on-situ” quadraplex isotope dimethyl labeling for the analysis of biogenic amines in beers by liquid chromatography-high resolution mass spectrometry. JOURNAL OF CHROMATOGRAPHY A, 1613 (460712). [PMID:31759641] [10.1016/j.chroma.2019.460712] |
34. Chen Jia, Li Yunchun, Huang Yanni, Zhang Haijuan, Chen Xingguo, Qiu Hongdeng. (2019) Fluorometric dopamine assay based on an energy transfer system composed of aptamer-functionalized MoS2 quantum dots and MoS2 nanosheets. MICROCHIMICA ACTA, 186 (2): (1-9). [PMID:30617543] [10.1007/s00604-018-3143-5] |
35. Wang Zhong-Xia, Gao Yuan-Fei, Yu Xian-He, Kong Fen-Ying, Lv Wei-Xin, Wang Wei. (2018) Photoluminescent coral-like carbon-branched polymers as nanoprobe for fluorometric determination of captopril. MICROCHIMICA ACTA, 185 (9): (1-9). [PMID:30128634] [10.1007/s00604-018-2961-9] |
36. Liu Xinnan, Zhang Wentao, Huang Lunjie, Hu Na, Liu Wei, Liu Yingnan, Li Sihang, Yang Chengyuan, Suo Yourui, Wang Jianlong. (2018) Fluorometric determination of dopamine by using molybdenum disulfide quantum dots. MICROCHIMICA ACTA, 185 (4): (1-8). [PMID:29594717] [10.1007/s00604-018-2771-0] |
37. Yirui Zhao,Xue Sang,Hongshun Hao,Jingran Bi,Gongliang Zhang,Hongman Hou. (2021-02-12) Novel starter cultures Virgibacillus spp. selected from grasshopper sub shrimp paste to inhibit biogenic amines accumulation.. AMB Express, 11 ((1)): (25-25). [PMID:33569734] |
1. Peng Nie, Xiang Gao, Xuefei Yang, Yang Zhang, Haijie Lu, Heng Wang, Zhi Zheng, Yizhong Shen. (2024) AIE fluorogen-based oxidase-like fluorescence nanozyme-integrated smartphone for monitoring the freshness authenticity of soy products. FOOD CHEMISTRY, 439 (28): (138122). [PMID:38070231] [10.1016/j.foodchem.2023.138122] |
2. Yiting Xu, Xiaobo Yu, Meiling Chen, Yi Sun, Wei Zhang, Yajin Fang, Lanyun Fang, Haining Na, Fei Liu, Jin Zhu. (2023) Dual responsive cellulose-based fluorescent material fabricated in a CO2 switchable solvent for multifunctional applications. CHEMICAL ENGINEERING JOURNAL, 477 (147272). [PMID:12871148] [10.1016/j.cej.2023.147272] |
3. Junjun Wang, Yue Tang, Jia Zheng, Zhengmin Xie, Jianli Zhou, Yuangen Wu. (2024) DNAzyme-based and smartphone-assisted colorimetric biosensor for ultrasensitive and highly selective detection of histamine in meats. FOOD CHEMISTRY, 435 (13): (137526). [PMID:37742463] [10.1016/j.foodchem.2023.137526] |
4. Zekun Shi, Yongning Wu, Xue Zhang, Yanyan Gao, Luqin Qiao, Qin Hou, Minglin Wang. (2023) Highly sensitive and selective colorimetric and fluorescent dual-readout assay for the analysis of spermine, spermidine and cysteine. DYES AND PIGMENTS, 220 (111659). [PMID:] [10.1016/j.dyepig.2023.111659] |
5. Xiang Gao, Peng Nie, Peiran Li, Zhi Zheng, Jieshun Cheng, Ying Gu, Yizhong Shen. (2023) Silver metallization-triggered liposome-embedded AIE fluorophore for dual-mode detection of biogenic amines to fight food freshness fraud. FOOD CHEMISTRY, 429 (136961). [PMID:37499507] [10.1016/j.foodchem.2023.136961] |
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