HLM 006474 - ≥98%(HPLC), high purity , CAS No.353519-63-8

Item Number

H288701

Grouped product items
SKU	Size	Availability	Price
H288701-10mg	10mg	In stock	$118.90
H288701-50mg	50mg	In stock	$391.90
H288701-100mg	100mg	In stock	$652.90
H288701-250mg	250mg	In stock	$1,469.90

E2F transcription factor inhibitor

Basic Description

Synonyms	7-[(4-Ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-8-quinolinol
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	E2F transcription factor inhibitor; inhibits E2F DNA binding activity. Inhibits E2F4 DNA binding and reduces E2F4 protein levels in A375 melanoma cells. Induces apoptosis of A375 and MDA-MB-231 breast cancer cells. Inhibits A375 proliferation and invasion
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	HLM 006474 acts as an E2F transcription factor inhibitor, preventing DNA binding activity. This results in the induction of apoptosis in breast cancer cells.

Names and Identifiers

IUPAC Name	7-[(4-ethoxy-3-methylphenyl)-(pyridin-2-ylamino)methyl]-2-methylquinolin-8-ol
INCHI	InChI=1S/C25H25N3O2/c1-4-30-21-13-11-19(15-16(21)2)23(28-22-7-5-6-14-26-22)20-12-10-18-9-8-17(3)27-24(18)25(20)29/h5-15,23,29H,4H2,1-3H3,(H,26,28)
InChi Key	CYNZBLNMIJNBSF-UHFFFAOYSA-N
Canonical SMILES	CCOC1=C(C=C(C=C1)C(C2=C(C3=C(C=CC(=N3)C)C=C2)O)NC4=CC=CC=N4)C
Isomeric SMILES	CCOC1=C(C=C(C=C1)C(C2=C(C3=C(C=CC(=N3)C)C=C2)O)NC4=CC=CC=N4)C
PubChem CID	2895500
Molecular Weight	399.48

Certificates

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4 results found

Lot Number	Certificate Type	Date	Item
H2206472	Certificate of Analysis	Jun 07, 2022	H288701
H2206476	Certificate of Analysis	Jun 07, 2022	H288701
H2206477	Certificate of Analysis	Jun 07, 2022	H288701
H2206478	Certificate of Analysis	Jun 07, 2022	H288701

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H413:May cause long lasting harmful effects to aquatic life H302:Harmful if swallowed
Precautionary Statements	P301+P312+P330:IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth.
RIDADR	NONHforallmodesoftransport

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Basic Description