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SKU | Size | Availability | Price | Qty |
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H125770-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $97.90 | |
H125770-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $441.90 | |
H125770-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $706.90 |
Synonyms | BRD-K70511574-001-01-0 | (E)-4-(2-(2-(N-Acetyl-N-((p-methoxyphenyl)sulfonyl)amino)phenyl)ethenyl)pyridine 1-oxide | acetaldehyde N-tert-butylimine | NSC 68654 | HY-12045 | Acetamide, N-((4-methoxyphenyl)sulfonyl)-N-(2-(2-(1-oxido-4-pyridinyl)ethenyl)pheny |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | HMN-214 (IVX-214) is a potent inhibitor of Polo-like kinase (Plk) with IC50 of 118 nM. HMN-214 shows potent and broad-spectrum anti-tumor activity against various cancer cells, including HeLa, PC-3, DU-145, MIAPaCa-2, U937, MCF-7, A549, and WiDr, with a m |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | 卖完停产,不再备货 |
Product Description | HMN-214 is a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | N-(4-methoxyphenyl)sulfonyl-N-[2-[(E)-2-(1-oxidopyridin-1-ium-4-yl)ethenyl]phenyl]acetamide |
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INCHI | InChI=1S/C22H20N2O5S/c1-17(25)24(30(27,28)21-11-9-20(29-2)10-12-21)22-6-4-3-5-19(22)8-7-18-13-15-23(26)16-14-18/h3-16H,1-2H3/b8-7+ |
InChi Key | OCKHRKSTDPOHEN-BQYQJAHWSA-N |
Canonical SMILES | CC(=O)N(C1=CC=CC=C1C=CC2=CC=[N+](C=C2)[O-])S(=O)(=O)C3=CC=C(C=C3)OC |
Isomeric SMILES | CC(=O)N(C1=CC=CC=C1/C=C/C2=CC=[N+](C=C2)[O-])S(=O)(=O)C3=CC=C(C=C3)OC |
PubChem CID | 9888590 |
Molecular Weight | 424.48 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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E1704088 | Certificate of Analysis | Dec 08, 2022 | H125770 |
Solubility | DMSO 12 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
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