HMR 1556 - ≥98%(HPLC), high purity , CAS No.223749-46-0, Channel blocker of K v7.1

Item Number

H286704

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SKU	Size	Availability	Price	Qty
H286704-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$246.90

Potent and selective Ikschannel blocker

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Basic Description

Synonyms	HMR 1556 \| 223749-46-0 \| chromanol HMR1556 \| HMR-1556 \| UNII-4IF4R31066 \| (+)-HMR-1556 \| N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide \| 4IF4R31066 \| CHEMBL298475 \| (3R,4S)-(+)-N-(3-hydroxy-2,2-dimet
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent and selective Ikschannel blocker (IC50values are 10.5 and 34 nM in canine and guinea pig ventricular myocytes respectively). Selectively inhibits IKscurrents over IKr, IKI, Itoand L-type Ca2+channel currents. Also has little or no effect on Kv11.1
Storage Temp	Room temperature
Shipped In	Normal
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of K v7.1

Associated Targets(Human)

KCNQ1 Tclin Potassium voltage-gated channel subfamily KQT member 1 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin HERG (29587 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNQ1 Tclin Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) (185 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-[(3R,4S)-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-3,4-dihydrochromen-4-yl]-N-methylmethanesulfonamide
INCHI	InChI=1S/C17H24F3NO5S/c1-16(2)15(22)14(21(3)27(4,23)24)12-10-11(6-7-13(12)26-16)25-9-5-8-17(18,19)20/h6-7,10,14-15,22H,5,8-9H2,1-4H3/t14-,15+/m0/s1
InChi Key	SRZRLJWUQFIZRH-LSDHHAIUSA-N
Canonical SMILES	CC1(C(C(C2=C(O1)C=CC(=C2)OCCCC(F)(F)F)N(C)S(=O)(=O)C)O)C
Isomeric SMILES	CC1([C@@H]([C@H](C2=C(O1)C=CC(=C2)OCCCC(F)(F)F)N(C)S(=O)(=O)C)O)C
PubChem CID	9887834
Molecular Weight	411.44

PubChem CID

CAS Registry No.

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Basic Description