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Voltage-gated ion channels
Potassium channels
HMR 1556 - ≥98%(HPLC), high purity , CAS No.223749-46-0, Channel blocker of K v7.1

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HMR 1556 - ≥98%(HPLC), high purity , CAS No.223749-46-0, Channel blocker of K v7.1

Moligand™

≥98%(HPLC)

CAS#: 223749-46-0
Formula: C₁₇H₂₄F₃NO₅S
Molecular Weight: 411.44
PubChem CID: 9887834

Item Number

H286704

Grouped product items
SKU	Size	Availability	Price	Qty
H286704-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$246.90

Potent and selective Ikschannel blocker

View related series

Kv7.1 Channel blocker Membrane Transporter/Ion Channel Potassium Channel

Basic Description

Synonyms	CS-0025669 \| (+)-HMR-1556 \| (3R,4S)-(+)-N-(3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)chroman-4-yl)-N-methylmethanesulfonamide \| NCGC00387222-01 \| 4IF4R31066 \| SCHEMBL4623436 \| D85486 \| Methanesulfonamide, N-((3R,4S)-3,4-dihydro-3-hydroxy-2,2-dimethy
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent and selective Ikschannel blocker (IC50values are 10.5 and 34 nM in canine and guinea pig ventricular myocytes respectively). Selectively inhibits IKscurrents over IKr, IKI, Itoand L-type Ca2+channel currents. Also has little or no effect on Kv11.1
Storage Temp	Room temperature
Shipped In	Normal
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of K v7.1

Associated Targets(Human)

KCNQ1 Tclin Potassium voltage-gated channel subfamily KQT member 1 (1 Activities)

Discover Target: KCNQ1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

KCNQ1 Voltage-gated potassium channel subunit Kv7.1 (54 Activities)

Discover Target: KCNQ1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	N-[(3R,4S)-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-3,4-dihydrochromen-4-yl]-N-methylmethanesulfonamide
INCHI	InChI=1S/C17H24F3NO5S/c1-16(2)15(22)14(21(3)27(4,23)24)12-10-11(6-7-13(12)26-16)25-9-5-8-17(18,19)20/h6-7,10,14-15,22H,5,8-9H2,1-4H3/t14-,15+/m0/s1
InChi Key	SRZRLJWUQFIZRH-LSDHHAIUSA-N
Canonical SMILES	CC1(C(C(C2=C(O1)C=CC(=C2)OCCCC(F)(F)F)N(C)S(=O)(=O)C)O)C
Isomeric SMILES	CC1([C@@H]([C@H](C2=C(O1)C=CC(=C2)OCCCC(F)(F)F)N(C)S(=O)(=O)C)O)C
PubChem CID	9887834
Molecular Weight	411.44

Database links

PubChem CID	9867091
CAS Registry No.	223749-46-0

Certificates

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Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 41.14, Max Conc. mM: 100

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