Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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H111272-50mg | 50mg | In stock | $9.90 | |
H111272-200mg | 200mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $13.90 | |
H111272-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $15.90 | |
H111272-1g | 1g | In stock | $19.90 | |
H111272-5g | 5g | In stock | $62.90 | |
H111272-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $213.90 |
Anti-inflammatory and chemotherapeutic agent
Synonyms | 3',5-(5,5'-)Diallyl-[1,1'-biphenyl]-2,4'-(2,2'-)diol | BDBM50157304 | DTXSID30188845 | FT-0601638 | {1,1'-Biphenyl]-2,4'-diol, 3,5-di-2-propenyl- | FMLT BSASM H | HONOKIOL [WHO-DD] | MLS006011755 | 4-[2-hydroxy-5-(prop-2-en-1-yl)phenyl]-2-(prop-2-en-1-yl) |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Potent scavenger of reactive oxygen species with antiangiogenic, antitumor and anti-inflammatory properties. Mechanisms of action include inhibition of ras signalling and activation of the mitochondrial transistion pore via cyclophilin D induction. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of 5-LOX |
Note | 50mg/200mg 售完停产 Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488184688 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488184688 |
IUPAC Name | 2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol |
INCHI | InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2 |
InChi Key | FVYXIJYOAGAUQK-UHFFFAOYSA-N |
Canonical SMILES | C=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C |
Isomeric SMILES | C=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C |
WGK Germany | 3 |
PubChem CID | 72303 |
UN Number | 3077 |
Molecular Weight | 266.33 |
Reaxy-Rn | 1982052 |
PubChem CID | 72303 |
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CAS Registry No. | 35354-74-6 |
ChEMBL Ligand | CHEMBL16901 |
BindingDB Ligand | 50157304 |
PubChem SID | 488184688 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
K2413301 | Certificate of Analysis | Nov 19, 2024 | H111272 |
K2413302 | Certificate of Analysis | Nov 19, 2024 | H111272 |
F1707005 | Certificate of Analysis | Aug 12, 2024 | H111272 |
E2409036 | Certificate of Analysis | May 16, 2024 | H111272 |
D2417328 | Certificate of Analysis | Apr 23, 2024 | H111272 |
D2417338 | Certificate of Analysis | Apr 23, 2024 | H111272 |
K2116360 | Certificate of Analysis | Aug 09, 2023 | H111272 |
K2116361 | Certificate of Analysis | Aug 09, 2023 | H111272 |
B2309608 | Certificate of Analysis | Feb 17, 2023 | H111272 |
B2309655 | Certificate of Analysis | Feb 17, 2023 | H111272 |
B2309684 | Certificate of Analysis | Feb 17, 2023 | H111272 |
B2309818 | Certificate of Analysis | Feb 17, 2023 | H111272 |
B2309867 | Certificate of Analysis | Feb 17, 2023 | H111272 |
C2223350 | Certificate of Analysis | Apr 30, 2022 | H111272 |
G1826038 | Certificate of Analysis | Apr 14, 2022 | H111272 |
C2019087 | Certificate of Analysis | Jan 18, 2022 | H111272 |
Solubility | Soluble in Methanol |
---|---|
Sensitivity | Heat Sensitive |
Melt Point(°C) | 85°C |
Pictogram(s) | GHS09, GHS05, GHS07 |
---|---|
Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H318:Causes serious eye damage |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
Reaxy-Rn | 1982052 |
Merck Index | 4742 |
1. Fei Li, Chunyu Ye, Xiuli Wang, Xinting Li, Xiaoxia Wang. (2023) Honokiol ameliorates cigarette smoke-induced damage of airway epithelial cells via the SIRT3/SOD2 signalling pathway. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, (1): [PMID:37795870] |
2. Chuanyi Gu, Chunru Wang, Wenjie Ma, Yunli Gao, Junyao Li, Qing Jin, Xiaochen Wu. (2023) Drug-Loaded Konjac Glucomannan/Metal–Organic Framework Composite Hydrogels as Antibacterial and Anti-Inflammatory Cell Scaffolds. ACS Applied Materials & Interfaces, 15 (35): (41287–41298). [PMID:37632730] |
3. Man Hu, Wen Jiang, Chen Ye, Ting Hu, Qingqing Yu, Moran Meng, Lijuan Sun, Jichao Liang, Yong Chen. (2023) Honokiol attenuates high glucose-induced peripheral neuropathy via inhibiting ferroptosis and activating AMPK/SIRT1/PGC-1ɑ pathway in Schwann cells. PHYTOTHERAPY RESEARCH, [PMID:37580045] |
4. Guoyu Wei, Wei Zhao, Anlong Hu, Mingjian Ren, Yunxiao Huang, Huayang Xu. (2023) Identification of a New Pathogenic fungi Causing Sorghum Leaf Spot Disease and Its Management Using Natural Product and Microorganisms. Microorganisms, 11 (6): (1431). [PMID:37374932] |
5. Yuan Hu, Miao Zhang, Bihan Liu, Yingying Tang, Zhuo Wang, Tao Wang, Jiaxin Zheng, Junjian Zhang. (2023) Honokiol prevents chronic cerebral hypoperfusion induced astrocyte A1 polarization to alleviate neurotoxicity by targeting SIRT3-STAT3 axis. FREE RADICAL BIOLOGY AND MEDICINE, 202 (62). [PMID:36997099] |
6. Meiying Ge, Guozheng Liang, Aijuan Gu. (2023) A facile strategy and mechanism to achieve biobased bismaleimide resins with high thermal-resistance and strength through copolymerizing with unique propargyl ether-functionalized allyl compound. REACTIVE & FUNCTIONAL POLYMERS, 186 (105570). [PMID:] |
7. Weizhen Wang, Linan He, Zhuzhu Zhang, Wenzhi Li, Jia Chen, Tingting Chen, Youhua Long. (2023) Activity of the botanical compound thymol against kiwifruit rot caused by Fusarium tricinctum and the underlying mechanisms. PEST MANAGEMENT SCIENCE, [PMID:36864770] |
8. Wang Yixi, Ding Chuanyang, Ge Zhangjie, Li Zhipeng, Chen Lixin, Guo Xiaolong, Dong Genxi, Zhou Ping. (2023) A novel antibacterial and fluorescent coating composed of polydopamine and carbon dots on the surface of orthodontic brackets. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 34 (2): (1-12). [PMID:36802301] |
9. Qingcong Wei, Ziming Jin, Weiwei Zhang, Yanfei Zhao, Yaxing Wang, Yixing Wei, Xing He, Guanglei Ma, Yuming Guo, Yuqin Jiang, Zhiguo Hu. (2023) Honokiol@PF127 crosslinked hyaluronate-based hydrogel for promoting wound healing by regulating macrophage polarization. CARBOHYDRATE POLYMERS, 303 (120469). [PMID:36657865] |
10. Junzhao Yuan, Xiaoqian Huang, Jianhong Gu, Yan Yuan, Zongping Liu, Hui Zou, Jianchun Bian. (2023) Honokiol reduces cadmium-induced oxidative injury and endosomal/lysosomal vacuolation via protecting mitochondrial function in quail (Coturnix japonica) liver tissues. SCIENCE OF THE TOTAL ENVIRONMENT, 857 (159626). [PMID:36280083] |
11. Yuyan Zhu, Lixia Zhang, Xiyuan Zhou. (2022) Honokiol Improves Acne-like Lesions in a Rabbit Ear Model by Alleviating Hyperkeratosis and Sebum Secretion. Natural Product Communications, [PMID:] |
12. Bo Yu, Yiping Shen, Xuejie Zhang, Lijuan Ding, Zheng Meng, Xiaotong Wang, Meihua Han, Yifei Guo, Xiangtao Wang. (2022) Poly(methacrylate citric acid) as a Dual Functional Carrier for Tumor Therapy. Pharmaceutics, 14 (9): (1765). [PMID:36145512] |
13. Xin-Yuan Jiang, Zong-Yi Ren, Nian-Kun Zhang, Ke-Chen Yang, Gao-Xue Wang, Hai-Feng Jiang. (2022) Screening and evaluating honokiol from Magnolia officinalis against Nocardia seriolae infection in largemouth bass (Micropterus Salmoides). JOURNAL OF FISH DISEASES, 45 (11): (1599-1607). [PMID:35801398] |
14. Peng-Bo Duan, Ping-Ting Xiao, Xing Yang, Jin-Hua Hao, Kai Li, E-Hu Liu. (2022) Screening of hypoglycemic components in Platycladi Cacumen by phytochemical investigation, spectrum-effect relationship, and chemometric methods. JOURNAL OF SEPARATION SCIENCE, 45 (14): (2591-2602). [PMID:35593082] |
15. Hang Sun, Youjie Li, Xiao Wang, Xue Zhou, Simin Rong, Dongmin Liang, Guangbin Sun, Huizhen Cao, Hongfang Sun, Ranran Wang, Yunfei Yan, Shuyang Xie, Yunxiao Sun. (2022) TRIB2 regulates the expression of miR‑33a‑5p through the ERK/c‑Fos pathway to affect the imatinib resistance of chronic myeloid leukemia cells. INTERNATIONAL JOURNAL OF ONCOLOGY, 60 (5): (1-14). [PMID:35302171] |
16. Feixu Mo, Xianfeng Hu, Yi Ding, Rongyu Li, Youhua Long, Xiaomao Wu, Ming Li. (2021) Naturally produced magnolol can significantly damage the plasma membrane of Rhizoctonia solani. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 178 (104942). [PMID:34446208] |
17. Jingwei Zhou, Yaoyao Hu, Peichun Chen, Hongwu Zhang. (2020) Preparation of restricted access monolithic tip via unidirectional freezing and atom transfer radical polymerization for directly extracting magnolol and honokiol from rat plasma followed by liquid chromatography analysis. JOURNAL OF CHROMATOGRAPHY A, 1625 (461238). [PMID:32709314] |
18. Qinglin He, Hua Yin, Jingjie Jiang, Yanfen Bai, Ning Chen, Shaowei Liu, Yibin Zhuang, Tao Liu. (2017) Fermentative Production of Phenolic Glucosides by Escherichia coli with an Engineered Glucosyltransferase from Rhodiola sachalinensis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 65 (23): (4691–4697). [PMID:28547990] |
19. Jing Sun, Xueqi Fu, Ye Liu, Yongsen Wang, Bo Huo, Yidi Guo, Xuefeng Gao, Wannan Li, Xin Hu. (2015) Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice. Drug Design Development and Therapy, 9 ( 6327–6342). [PMID:26674084] |
20. Xu T, Meng JR, Cheng W, Liu JZ, Chu J, Zhang Q, Ma N, Bai LP, Guo Y.. (2022) Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors.. Bioorg Med Chem, 67 (116838-116838). [PMID:35617790] |
1. Pan J, Lee Y, Wang Y, You M. (2016) Honokiol targets mitochondria to halt cancer progression and metastasis.. Mol Nutr Food Res, 60 (6): (1383-95). [PMID:27276215] |
2. Mottaghi S, Abbaszadeh H. (2021) Natural Lignans Honokiol and Magnolol as Potential Anticarcinogenic and Anticancer Agents. A Comprehensive Mechanistic Review.. Nutr Cancer, 71 (13): (1-18). [PMID:34047218] |
3. Banik K, Ranaware AM, Deshpande V, Nalawade SP, Padmavathi G, Bordoloi D, Sailo BL, Shanmugam MK, Fan L, Arfuso F et al.. (2019) Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets.. Pharmacol Res, 144 (13): (192-209). [PMID:31002949] |
4. Chen C, Zhang QW, Ye Y, Lin LG. (2021) Honokiol: A naturally occurring lignan with pleiotropic bioactivities. Chin J Nat Med, 19 (7): (481-490). [PMID:34247771] |
5. Ong CP, Lee WL, Tang YQ, Yap WH. (2019) Honokiol: A Review of Its Anticancer Potential and Mechanisms.. Cancers (Basel), 12 (1): (1755-70). [PMID:31877856] |
6. Fei Li, Chunyu Ye, Xiuli Wang, Xinting Li, Xiaoxia Wang. (2023) Honokiol ameliorates cigarette smoke-induced damage of airway epithelial cells via the SIRT3/SOD2 signalling pathway. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, (1): [PMID:37795870] |
7. Chuanyi Gu, Chunru Wang, Wenjie Ma, Yunli Gao, Junyao Li, Qing Jin, Xiaochen Wu. (2023) Drug-Loaded Konjac Glucomannan/Metal–Organic Framework Composite Hydrogels as Antibacterial and Anti-Inflammatory Cell Scaffolds. ACS Applied Materials & Interfaces, 15 (35): (41287–41298). [PMID:37632730] |
8. Man Hu, Wen Jiang, Chen Ye, Ting Hu, Qingqing Yu, Moran Meng, Lijuan Sun, Jichao Liang, Yong Chen. (2023) Honokiol attenuates high glucose-induced peripheral neuropathy via inhibiting ferroptosis and activating AMPK/SIRT1/PGC-1ɑ pathway in Schwann cells. PHYTOTHERAPY RESEARCH, [PMID:37580045] |
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10. Yuan Hu, Miao Zhang, Bihan Liu, Yingying Tang, Zhuo Wang, Tao Wang, Jiaxin Zheng, Junjian Zhang. (2023) Honokiol prevents chronic cerebral hypoperfusion induced astrocyte A1 polarization to alleviate neurotoxicity by targeting SIRT3-STAT3 axis. FREE RADICAL BIOLOGY AND MEDICINE, 202 (62). [PMID:36997099] |
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