HS024 TFA, CAS No.212370-59-7(free base), Antagonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Antagonist of MC 5 receptor

Features and benefits
    Item Number
    H288535
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    H288535-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $129.90
    H288535-5mg
    5mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $299.90
    H288535-10mg
    10mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $499.90
    H288535-25mg
    25mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $999.90

    Highly potent MC4receptor antagonist

    Basic Description

    Product NameHS024 TFA, CAS No.212370-59-7(free base)
    SynonymsAKOS024456803 | HS 024 | N-Acetyl-L-cysteinyl-L-norleucyl-L-arginyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinamide cyclic (1->9)disulfide | HS024 | DTXSID301034918 | Long Name (Added to Synonym)
    GradeMoligand™
    Specifications & PurityMoligand™, ≥95%
    Biochemical and Physiological MechanismsHighly potent melanocortin MC4receptor antagonist (Kivalues are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3and MC5receptors respectively). Increases food intake, and blocksα-MSH- and MTII-induced hypotension and bradycardia in rats, follow
    SequenceCXRHXRWGC(Modifications: Cys-1 = N-terminal Ac, X-2 = Nle, X-5 = Nal, Cys-9 = C-terminal amide, Disulfide bridge between 1 - 9)
    Action TypeANTAGONIST
    Mechanism of actionAntagonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Antagonist of MC 5 receptor

    Associated Targets(Human)

    MC5R Tchem Melanocortin receptor 5 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    MC4R Tclin Melanocortin receptor 4 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    MC3R Tchem Melanocortin receptor 3 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    MC1R Tclin Melanocyte-stimulating hormone receptor (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    Storage TempStore at -20°C,Desiccated
    Shipped InIce chest + Ice pads
    CAS212370-59-7(free base)

    Certificates

    Certificate of Analysis(COA)

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    8 results found

    Lot NumberCertificate TypeDateItem
    F2403035Certificate of AnalysisFeb 20, 2024 H288535
    F2403036Certificate of AnalysisFeb 20, 2024 H288535
    F2403037Certificate of AnalysisFeb 20, 2024 H288535
    F2403038Certificate of AnalysisFeb 20, 2024 H288535
    F2403039Certificate of AnalysisFeb 20, 2024 H288535
    F2403040Certificate of AnalysisFeb 20, 2024 H288535
    F2403041Certificate of AnalysisFeb 20, 2024 H288535
    F2403042Certificate of AnalysisFeb 20, 2024 H288535

    Genetic information

    Alternate NamesAKOS024456803 | HS 024 | N-Acetyl-L-cysteinyl-L-norleucyl-L-arginyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinamide cyclic (1->9)disulfide | HS024 | DTXSID301034918 | Long Name (Added to Synonym)
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

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