HSK3486 , GABA-A receptor; anion channel agonist, CAS No.1637741-58-2, GABA-A receptor; anion channel agonist

Item Number

H610863

Grouped product items
SKU	Size	Availability	Price
H610863-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$99.90
H610863-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$922.90
H610863-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$359.90
H610863-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$719.90
H610863-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$999.90

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Basic Description

Synonyms	AKOS040752041 \| 2-[(1R)-1-cyclopropylethyl]-6-propan-2-ylphenol \| Cipepofol [USAN] \| M3WGS532VY \| 2-[(1r)-1-cyclopropylethyl]-6-isopropylphenol \| 2-[(1R)-1-cyclopropylethyl]-6-isopropyl-phenol \| HSK3486 \| HSK-3486 \| PHenol, 2-[(1R)-1-cyclopropylethyl]-6-(
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	GABA-A receptor; anion channel agonist
Product Description	Cipepofol (Ciprofol), a novel 2,6-disubstituted phenol derivative, is a positive allosteric modulator and direct agonist of the GABAA receptor. Cipepofol can cause the central nerve inhibition and promote sleep based on the structural modification of Propofol (HY-B0649). Cipepofol can activate the sirtuin1 (Sirt1)/Nrf2 pathway. Cipepofol protects the heart against Isoproterenol (ISO; HY-B0468)-induced myocardial infarction by reducing cardiac oxidative stress, inflammatory response and cardiomyocyte apoptosis.

Associated Targets(non-human)

Canis familiaris (36305 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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Names and Identifiers

IUPAC Name	2-[(1R)-1-cyclopropylethyl]-6-propan-2-ylphenol
INCHI	InChI=1S/C14H20O/c1-9(2)12-5-4-6-13(14(12)15)10(3)11-7-8-11/h4-6,9-11,15H,7-8H2,1-3H3/t10-/m1/s1
InChi Key	BMEARIQHWSVDBS-SNVBAGLBSA-N
Canonical SMILES	C[C@@H](c1cccc(c1O)C(C)C)C1CC1
Isomeric SMILES	C[C@H](C1CC1)C2=CC=CC(=C2O)C(C)C
PubChem CID	86301664
Molecular Weight	204.31

PubChem CID

ChEMBL Ligand

CAS Registry No.

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Basic Description