HU-308 - ≥98%, high purity , CAS No.256934-39-1, Agonist of CB 2 receptor;Antagonist of glycine receptor α1 subunit;Antagonist of glycine receptor α2 subunit;Antagonist of glycine receptor α3 subunit

Item Number
H275933
Grouped product items
SKUSizeAvailabilityPrice Qty
H275933-1mg
1mg
In stock
$240.90
H275933-5mg
5mg
In stock
$1,029.90

Selective cannabinoid receptor 2 (CB2) agonist

Basic Description

Synonyms[(1~{S},4~{S},5~{S})-4-[2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl]-6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl]methanol | 8I5L034D55 | DTXSID801017327 | CHEBI:146244 | ONTERNABEZ [INN] | PPP-003 | (1S,4S,5S)-4-(4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL)-6,
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsHU-308 is a potent, selective agonist of the cannabinoid receptor CB2. The Ki values for CB2 vs. CB1 are 22.7nM and >10 mM, respectively. HU-308 has anti-inflammatory and neuroprotective properties, and reduces liver damage in a hepatic ischemia/reperfusi
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST, ANTAGONIST
Mechanism of actionAgonist of CB 2 receptor;Antagonist of glycine receptor α1 subunit;Antagonist of glycine receptor α2 subunit;Antagonist of glycine receptor α3 subunit
NoteRefer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Shipped at Room Temperature. Store at -20°C long term.

Associated Targets(Human)

CNR2 Tchem Cannabinoid receptor 2 (8 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GLRA2 Tchem Glycine receptor subunit alpha-2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GLRA1 Tclin Glycine receptor subunit alpha-1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GLRA3 Tchem Glycine receptor subunit alpha-3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR2 Tchem Cannabinoid CB2 receptor (16942 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name [(1S,4S,5S)-4-[2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl]-6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl]methanol
INCHI InChI=1S/C27H42O3/c1-8-9-10-11-12-26(2,3)19-14-23(29-6)25(24(15-19)30-7)20-13-18(17-28)21-16-22(20)27(21,4)5/h13-15,20-22,28H,8-12,16-17H2,1-7H3/t20-,21+,22-/m0/s1
InChi Key CFMRIVODIXTERW-BDTNDASRSA-N
Canonical SMILES CCCCCCC(C)(C)C1=CC(=C(C(=C1)OC)C2C=C(C3CC2C3(C)C)CO)OC
Isomeric SMILES CCCCCCC(C)(C)C1=CC(=C(C(=C1)OC)[C@H]2C=C([C@H]3C[C@@H]2C3(C)C)CO)OC
PubChem CID 11553430
Molecular Weight 414.62(Anhydrous)

Certificates

Certificate of Analysis(COA)

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4 results found

Lot NumberCertificate TypeDateItem
K2212517Certificate of AnalysisAug 17, 2023 H275933
K2212518Certificate of AnalysisAug 17, 2023 H275933
L2118416Certificate of AnalysisJul 12, 2023 H275933
L2118420Certificate of AnalysisJul 12, 2023 H275933

Chemical and Physical Properties

SolubilitySolubility in DMSO to 100mM and in ethanol to 100mM

Related Documents

Solution Calculators