Basic Description

Synonyms	ANGIOTENSIN II\|4474-91-3\|Angiotensin II human\|Human angiotensin II\|Hypertensin\|Ang II\|Angiotensin II (human)\|Angiotensin II (mouse)\|Giapreza\|5-L-Isoleucineangiotensin II\|5-Isoleucine-angiotensin II\|Asp-Arg-Val-Tyr-Ile-His-Pro-Phe\|1-8-Angiotensin I\|Angiote
Specifications & Purity	Angiotensin II:1045.5
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	AGONIST, CHANNEL BLOCKER
Mechanism of action	Agonist of AT 1 receptor;Agonist of AT 2 receptor;Channel blocker of K 2P3.1

Associated Targets

AGTR1 Tclin Type-1 angiotensin II receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AGTR2 Tchem Type-2 angiotensin II receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK3 Tclin Potassium channel subfamily K member 3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
INCHI	InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1
InChi Key	CZGUSIXMZVURDU-JZXHSEFVSA-N
Canonical SMILES	CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
Isomeric SMILES	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N
WGK Germany	3
RTECS	BW2165000
PubChem CID	172198
Molecular Weight	1046.18

Database links

PubChem CID	172198
UniProtKB	P01019, P11859, P01015
CAS Registry No.	4474-91-3
BindingDB Ligand	82077
ChEBI	CHEBI:48432
Wikipedia	Angiotensin_II#Angiotensin_II
ChEMBL Ligand	CHEMBL408403
PEP	angiotensin ii
DrugCentral Ligand	5272
Ensembl Gene	ENSG00000135744, ENSRNOG00000018445
GPCRdb Ligand	angiotensin II

Certificates

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2 results found

Lot Number	Certificate Type	Date	Item
E2317410	Certificate of Analysis	May 08, 2023	A119706
C2212179	Certificate of Analysis	Feb 15, 2022	A119706

Chemical and Physical Properties

Solubility	Soluble to 1 (mg/mL) in water}

Safety and Hazards(GHS)

WGK Germany	3
RTECS	BW2165000

FAQs and Articles

FAQ

A New Role for Angiotensin II in Aging

Categories: Technical articles

Tags:

Alzheimer's disease Neuropeptide Angiotensin hypertensive

References

1. Khanna A, English SW, Wang XS, Ham K, Tumlin J, Szerlip H, Busse LW, Altaweel L, Albertson TE, Mackey C et al.. (2017) Angiotensin II for the Treatment of Vasodilatory Shock.. N Engl J Med, 377 (5): (419-430). [PMID:28528561]

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Human angiotension Ⅱ Relative Molecular Weight - Angiotensin II:1045.5, high purity , CAS No.4474-91-3, Agonist of AT 1 receptor;Agonist of AT 2 receptor;Channel blocker of K 2P3.1