Humanin - ≥95.0%, high purity , CAS No.330936-69-1

Item Number

H647184

• Synonyms: Protein Humanin (human) | T lymphocyte activation-associated protein PRO86272 (human) | HUMANIN TRIFLUOROACETATE | GTPL1047 | Humanin (human) trifluoroacetate (H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-A
• Specifications & Purity: ≥95%
• Biochemical and Physiological Mechanisms: Humanin, an anti-apoptotic peptide of 24 amino acids , is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neu
• Storage Temp: Protected from light,Desiccated,Store at -80°C
• Shipped In: Ice chest + Ice pads

Product Description

Humanin, an anti-apoptotic peptide of 24 amino acids , is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG .

In Vitro

Humanin (40 nM, rhodamine-conjugated; 30 min) inhibits cell death induced by Bax protein in wild-type HCT116 cells. Humanin (100 μM; 10 min) blocks Bax association with isolated mitochondria, and suppresses cytochrome c release in wild-type HCT116 cells. Humanin reduces half apoptosis induced by 0.2 mM STS. Humanin fails to suppress apoptosis in Bax-deficient HCT116 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Humanin (0.375 mg/kg/hr; i.v.) increases peripheral insulin sensitivity in Zucker diabetic fatty (ZDF) rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Bax