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HX 531 - ≥98%(HPLC), high purity , CAS No.188844-34-0, Antagonist of Retinoid X receptor-α

  • Moligand™
  • ≥98%(HPLC)
Item Number
H287547
Grouped product items
SKUSizeAvailabilityPrice Qty
H287547-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$147.90
H287547-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$666.90
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Potent RXR antagonist

View related series
Retinoid X receptor-α Antagonist

Basic Description

SynonymsHX 531|188844-34-0|HX531|CHEMBL326525|4-(5,7,7,10,10-pentamethyl-2-nitro-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid|HX-531|CID 11755040|GTPL8079|SCHEMBL13752409|DTXSID801107570|HMS3743M05|BCP15618|BDBM50218464|HX-531;HX531|AKOS02445786
Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological MechanismsPotent RXR antagonist (IC50= 18 nM). Promotes white and brown pre-adipocyte differentiation into white adipocytes. Also inhibitsbexarotene-induced brown adipogenic reprogramming of myoblasts.
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of Retinoid X receptor-α

Associated Targets

RXRG Tclin Retinoic acid receptor RXR-gamma 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RXRB Tclin Retinoic acid receptor RXR-beta 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RXRA Tclin Retinoic acid receptor RXR-alpha 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-(5,7,7,10,10-pentamethyl-2-nitro-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid
INCHI InChI=1S/C29H29N3O4/c1-28(2)12-13-29(3,4)22-16-25-20(15-21(22)28)26(17-6-8-18(9-7-17)27(33)34)30-23-14-19(32(35)36)10-11-24(23)31(25)5/h6-11,14-16H,12-13H2,1-5H3,(H,33,34)
InChi Key SXKPGYKPQPYJER-UHFFFAOYSA-N
Canonical SMILES CC1(CCC(C2=C1C=C3C(=C2)N(C4=C(C=C(C=C4)[N+](=O)[O-])N=C3C5=CC=C(C=C5)C(=O)O)C)(C)C)C
Isomeric SMILES CC1(CCC(C2=C1C=C3C(=C2)N(C4=C(C=C(C=C4)[N+](=O)[O-])N=C3C5=CC=C(C=C5)C(=O)O)C)(C)C)C
PubChem CID 11755040
Molecular Weight 483.56

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 9.67, Max Conc. mM: 20

Safety and Hazards(GHS)

RIDADR NONHforallmodesoftransport

Related Documents

 SDS

 Specification Sheet

References

1. Ebisawa M, Umemiya H, Ohta K, Fukasawa H, Kawachi E, Christoffel G, Gronemeyer H, Tsuji M, Hashimoto Y, Shudo K et al..  (1999)  Retinoid X receptor-antagonistic diazepinylbenzoic acids..  Chem Pharm Bull,  47  (12): (1778-86).  [PMID:10748721]
2. Sakaki J, Konishi K, Kishida M, Gunji H, Kanazawa T, Uchiyama H, Fukaya H, Mitani H, Kimura M.  (2007)  Synthesis and structure-activity relationship of RXR antagonists based on the diazepinylbenzoic acid structure..  Bioorg Med Chem Lett,  17  (17): (4808-11).  [PMID:17651969]

Solution Calculators

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