Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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H110523-1g | 1g | In stock | $29.90 | |
H110523-5g | 5g | In stock | $103.90 | |
H110523-25g | 25g | In stock | $399.90 | |
H110523-100g | 100g | In stock | $1,205.90 |
Adrenal glucocorticoid; immunosuppressant
Synonyms | Cortisporin Otico | Evacort | Barseb HC | Cortenema | Penecort | Permicort | Synacort | Epiderm H | Polcort H | Timocort | Stiefcorcil | Incortin-hydrogen | Remederm HC | Signef | Alacort | Ala-Cort | Cortispray | Dome-cort | Kendall's compound F | Aerose |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Adrenal glucocorticoid. Stimulates gluconeogenesis, activates anxiolytic and anti-inflammatory pathways. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of Glucocorticoid receptor;Agonist of Mineralocorticoid receptor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | 1.6 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488179925 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179925 |
IUPAC Name | (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one |
INCHI | InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 |
InChi Key | JYGXADMDTFJGBT-VWUMJDOOSA-N |
Canonical SMILES | CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O |
Isomeric SMILES | C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O |
WGK Germany | 3 |
RTECS | GM8925000 |
PubChem CID | 5754 |
Molecular Weight | 362.46 |
Beilstein | 1354819 |
DrugBank Ligand | DB00741 |
---|---|
Wikipedia | Cortisol |
PubChem CID | 5754 |
BindingDB Ligand | 22476 |
ChEBI | CHEBI:17650 |
CAS Registry No. | 50-23-7 |
ChEMBL Ligand | CHEMBL389621 |
BitterDB Ligand | 129 |
NURSA Ligand | 10.1621/WQEMKA13C7 |
RCSB PDB Ligand | HCY |
PEP | cortisol |
Reactome Reaction | R-HSA-9678925 |
Reactome Drug | R-ALL-9678963 |
DrugCentral Ligand | 1388 |
PubChem SID | 488179925 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
L2017059 | Certificate of Analysis | Oct 14, 2024 | H110523 |
F2424253 | Certificate of Analysis | Jun 05, 2024 | H110523 |
F2424254 | Certificate of Analysis | Jun 05, 2024 | H110523 |
C2421443 | Certificate of Analysis | Mar 02, 2024 | H110523 |
C2414613 | Certificate of Analysis | Mar 02, 2024 | H110523 |
C2414614 | Certificate of Analysis | Mar 02, 2024 | H110523 |
C2414615 | Certificate of Analysis | Mar 02, 2024 | H110523 |
G2305907 | Certificate of Analysis | Jun 12, 2023 | H110523 |
E2420050 | Certificate of Analysis | Jun 12, 2023 | H110523 |
G2305861 | Certificate of Analysis | Jun 12, 2023 | H110523 |
G2305860 | Certificate of Analysis | Jun 12, 2023 | H110523 |
G2305834 | Certificate of Analysis | Jun 12, 2023 | H110523 |
G2305837 | Certificate of Analysis | Jun 12, 2023 | H110523 |
G2305839 | Certificate of Analysis | Jun 12, 2023 | H110523 |
G2305841 | Certificate of Analysis | Jun 12, 2023 | H110523 |
G2305859 | Certificate of Analysis | Jun 12, 2023 | H110523 |
C2202542 | Certificate of Analysis | Dec 03, 2021 | H110523 |
C2202625 | Certificate of Analysis | Dec 03, 2021 | H110523 |
C2202543 | Certificate of Analysis | Dec 03, 2021 | H110523 |
C2202541 | Certificate of Analysis | Dec 03, 2021 | H110523 |
E2326302 | Certificate of Analysis | Dec 03, 2021 | H110523 |
E2324258 | Certificate of Analysis | Dec 03, 2021 | H110523 |
Solubility | It is soluble in DMSO and ethanol. |
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Sensitivity | light sensitive |
Melt Point(°C) | 211-214°C |
Pictogram(s) | GHS08 |
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Signal | Warning |
Hazard Statements | H373:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | GM8925000 |
Merck Index | 4787 |
Starting at $73.90
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27. Jingli Zhang, Lingling Zhu, Hong Shi, Huizhe Zheng. (2021) Protective effects of miR‑155‑5p silencing on IFN‑γ‑induced apoptosis and inflammation in salivary gland epithelial cells. Experimental and Therapeutic Medicine, 22 (2): (1-11). [PMID:34194560] [10.3892/etm.2021.10314] |
28. Zhang Jiayu, Lan Tingting, Han Xue, Xu Yuchan, Liao Li, Xie Li, Yang Bo, Tian Weidong, Guo Weihua. (2021) Improvement of ECM-based bioroot regeneration via N-acetylcysteine-induced antioxidative effects. Stem Cell Research & Therapy, 12 (1): (1-14). [PMID:33752756] [10.1186/s13287-021-02237-5] |
29. Yang Huiyi, He Qiyi, Chen Yingshan, Shen Ding, Xiao Huanxin, Eremin Sergei A., Cui Xiping, Zhao Suqing. (2020) Platinum nanoflowers with peroxidase-like property in a dual immunoassay for dehydroepiandrosterone. MICROCHIMICA ACTA, 187 (11): (1-12). [PMID:33025211] [10.1007/s00604-020-04528-9] |
30. Luyao Zheng, Zhiyuan Zhao, Ye Yang, Yaming Li, Chengxiao Wang. (2020) Novel skin permeation enhancers based on amino acid ester ionic liquid: Design and permeation mechanism. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 576 (119031). [PMID:31953082] [10.1016/j.ijpharm.2020.119031] |
31. Yuqing Shen, Jianyun Zhang, Jingqian Xie, Jing Liu. (2020) In vitro assessment of corticosteroid effects of eight chiral herbicides. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES, 55 (2): (91-102). [PMID:31524045] [10.1080/03601234.2019.1665408] |
32. Yanxia Li, Xiaoman Chen, Ling Xia, Xiaohua Xiao, Gongke Li. (2019) Magnetic metal-organic frameworks-101 functionalized with graphite-like carbon nitride for the efficient enrichment of glucocorticoids in cosmetics. JOURNAL OF CHROMATOGRAPHY A, 1606 (460382). [PMID:31353072] [10.1016/j.chroma.2019.460382] |
33. Mengru Bai, Qingquan Zeng, Yingchun Chen, Mingyang Chen, Ping Li, Zhiyuan Ma, Dongli Sun, Hui Zhou, Caihong Zheng, Su Zeng, Huidi Jiang. (2019) Maternal Plasma l-Carnitine Reduction During Pregnancy Is Mainly Attributed to OCTN2-Mediated Placental Uptake and Does Not Result in Maternal Hepatic Fatty Acid β-Oxidation Decline. DRUG METABOLISM AND DISPOSITION, 47 (6): (582-591). [PMID:30918014] [10.1124/dmd.119.086439] |
34. Zhang Yingyi, Li Liang, Wang Qi, Shen Mei, Han Weili, Yang Xuemei, Chen Lingyun, Ma Ande, Zhou Zhengzheng. (2019) Simultaneous determination of metabolic and elemental markers in methamphetamine-induced hepatic injury to rats using LC-MS/MS and ICP-MS. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 411 (15): (3361-3372). [PMID:31119349] [10.1007/s00216-019-01810-5] |
35. Yu Tian, Ran Wei, Bo Cai, Jinfeng Dong, Bin Deng, Yuxiu Xiao. (2016) Cationic gemini pyrrolidinium surfactants based sweeping-micellar electrokinetic chromatography for simultaneous detection of nine organic pollutants in environmental water. JOURNAL OF CHROMATOGRAPHY A, 1475 (95). [PMID:27839754] [10.1016/j.chroma.2016.11.001] |
36. Mei Yang, Youning Ma, Wenjun Gui, Yiping Ren, Guonian Zhu, Yihua Liu. (2015) Determination of 26 endocrine disrupting chemicals in fish and water using modified QuEChERS combined with solid-phase extraction and UHPLC-MS/MS. Analytical Methods, 7 (19): (8418-8431). [PMID:] [10.1039/C5AY01082A] |
37. Ya-bing Fan, Yu-Min Yin, Wen-Bin Jiang, Yi-Ping Chen, Jia-Wei Yang, Jia Wu, Meng-Xia Xie. (2014) Simultaneous determination of ten steroid hormones in animal origin food by matrix solid-phase dispersion and liquid chromatography–electrospray tandem mass spectrometry. FOOD CHEMISTRY, 142 (170). [PMID:24001828] [10.1016/j.foodchem.2013.06.104] |
38. Lei Ye, Qing Wang, Jinping Xu, Zhi-guo Shi, Li Xu. (2012) Restricted-access nanoparticles for magnetic solid-phase extraction of steroid hormones from environmental and biological samples. JOURNAL OF CHROMATOGRAPHY A, 1244 (46). [PMID:22621888] [10.1016/j.chroma.2012.04.075] |
39. Zhao JJ, Guo YQ, Yang DP, Xue X, Liu Q, Zhu LP, Yin S, Zhao ZM.. (2016) Chlojaponilactone B from Chloranthus japonicus: Suppression of Inflammatory Responses via Inhibition of the NF-κB Signaling Pathway.. J Nat Prod, 79 (9): (2257-2263). [PMID:27588583] [10.1021/acs.jnatprod.6b00355] |
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30. Luyao Zheng, Zhiyuan Zhao, Ye Yang, Yaming Li, Chengxiao Wang. (2020) Novel skin permeation enhancers based on amino acid ester ionic liquid: Design and permeation mechanism. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 576 (119031). [PMID:31953082] [10.1016/j.ijpharm.2020.119031] |
31. Yuqing Shen, Jianyun Zhang, Jingqian Xie, Jing Liu. (2020) In vitro assessment of corticosteroid effects of eight chiral herbicides. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES, 55 (2): (91-102). [PMID:31524045] [10.1080/03601234.2019.1665408] |
32. Yanxia Li, Xiaoman Chen, Ling Xia, Xiaohua Xiao, Gongke Li. (2019) Magnetic metal-organic frameworks-101 functionalized with graphite-like carbon nitride for the efficient enrichment of glucocorticoids in cosmetics. JOURNAL OF CHROMATOGRAPHY A, 1606 (460382). [PMID:31353072] [10.1016/j.chroma.2019.460382] |
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36. Mei Yang, Youning Ma, Wenjun Gui, Yiping Ren, Guonian Zhu, Yihua Liu. (2015) Determination of 26 endocrine disrupting chemicals in fish and water using modified QuEChERS combined with solid-phase extraction and UHPLC-MS/MS. Analytical Methods, 7 (19): (8418-8431). [PMID:] [10.1039/C5AY01082A] |
37. Ya-bing Fan, Yu-Min Yin, Wen-Bin Jiang, Yi-Ping Chen, Jia-Wei Yang, Jia Wu, Meng-Xia Xie. (2014) Simultaneous determination of ten steroid hormones in animal origin food by matrix solid-phase dispersion and liquid chromatography–electrospray tandem mass spectrometry. FOOD CHEMISTRY, 142 (170). [PMID:24001828] [10.1016/j.foodchem.2013.06.104] |
38. Lei Ye, Qing Wang, Jinping Xu, Zhi-guo Shi, Li Xu. (2012) Restricted-access nanoparticles for magnetic solid-phase extraction of steroid hormones from environmental and biological samples. JOURNAL OF CHROMATOGRAPHY A, 1244 (46). [PMID:22621888] [10.1016/j.chroma.2012.04.075] |
39. Zhao JJ, Guo YQ, Yang DP, Xue X, Liu Q, Zhu LP, Yin S, Zhao ZM.. (2016) Chlojaponilactone B from Chloranthus japonicus: Suppression of Inflammatory Responses via Inhibition of the NF-κB Signaling Pathway.. J Nat Prod, 79 (9): (2257-2263). [PMID:27588583] [10.1021/acs.jnatprod.6b00355] |