Grouped product items

SKU

Size

Availability

Price

Qty

H141480-250mg

250mg

In stock

$9.90

H141480-1g

In stock

$16.90

H141480-5g

In stock

$61.90

H141480-25g

25g

In stock

$204.90

H141480-100g

100g

Available within 4-8 weeks(?)

$735.90

H141480-500g

500g

Available within 4-8 weeks(?)

$3,308.90

Basic Description

Synonyms	HYDROXYCHLOROQUINE SULFATE \| 747-36-4 \| Hydroxychloroquine sulphate \| Ercoquin \| Plaquenil \| 2-((4-((7-Chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethanol sulfate \| Plaquinol \| Toremonil \| Quensyl \| Oxiklorin \| Plaquenil sulfate \| NSC 4375 \| TCMDC-123987 \| HCQ sulfate \| NSC-4375 \| E
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Hydroxychloroquine is also used for treating rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used as
Shipped In	Normal
Action Type	INHIBITOR
Mechanism of action	Toll-like receptor 9 antagonist
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

CYP1B1 Tchem Cytochrome P450 1B1 (0 Activities)

Discover Target: CYP1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)

Discover Target: SLCO1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (0 Activities)

Discover Target: ABCC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (0 Activities)

Discover Target: ABCC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC4 Tchem Multidrug resistance-associated protein 4 (0 Activities)

Discover Target: ABCC4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCB11 Tchem Bile salt export pump (0 Activities)

Discover Target: ABCB11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC2A1 Tchem Solute carrier family 2, facilitated glucose transporter member 1 (0 Activities)

Discover Target: SLC2A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP1B1 Tchem Cytochrome P450 1B1 (1148 Activities)

Discover Target: CYP1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC2A1 Tchem Glucose transporter (14755 Activities)

Discover Target: SLC2A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (1191 Activities)

Discover Target: ABCC2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ABCB11 Tchem Bile salt export pump (2311 Activities)

Discover Target: ABCB11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (718 Activities)

Discover Target: ABCC3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ABCC4 Tchem Multidrug resistance-associated protein 4 (785 Activities)

Discover Target: ABCC4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ht1 Hexose transporter 1 (14071 Activities)

Discover Target: ht1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Vero C1008 (1716 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol;sulfuric acid
INCHI	InChI=1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChi Key	JCBIVZZPXRZKTI-UHFFFAOYSA-N
Canonical SMILES	CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O
Isomeric SMILES	CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O
WGK Germany	3
RTECS	KK3342500
PubChem CID	12947
Molecular Weight	433.95
Reaxy-Rn	7242072

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

13 results found

Lot Number	Certificate Type	Date	Item
L2004156	Certificate of Analysis	Sep 11, 2024	H141480
E2026124	Certificate of Analysis	Mar 12, 2024	H141480
G2321115	Certificate of Analysis	Jul 28, 2023	H141480
C2226235	Certificate of Analysis	Feb 26, 2022	H141480
C2226241	Certificate of Analysis	Feb 26, 2022	H141480
C2226262	Certificate of Analysis	Feb 26, 2022	H141480
C2226274	Certificate of Analysis	Feb 26, 2022	H141480
C2226275	Certificate of Analysis	Feb 26, 2022	H141480
C2226513	Certificate of Analysis	Feb 26, 2022	H141480
C2405057	Certificate of Analysis	Feb 26, 2022	H141480
E2323030	Certificate of Analysis	Feb 26, 2022	H141480
G2321116	Certificate of Analysis	Feb 26, 2022	H141480
G2321117	Certificate of Analysis	Feb 26, 2022	H141480

Chemical and Physical Properties

Sensitivity	light sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H317:May cause an allergic skin reaction
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	KK3342500
Reaxy-Rn	7242072
Merck Index	4818

Citations of This Product

1. Jiezhou Pan, Haotian Liao, Guidong Gong, Yunxiang He, Qin Wang, Lang Qin, Yaoyao Zhang, Hirotaka Ejima, Blaise L. Tardy, Joseph J. Richardson, Jiaojiao Shang, Orlando J. Rojas, Yong Zeng, Junling Guo. (2023) Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels. JOURNAL OF CONTROLLED RELEASE, 360 (433). [PMID:37422124]
2. Ping Guan, Zhaoxu Meng, Xinran Liu, Jiaxiang Mu, Zichun Gao, Xinrong Yu, He Lian. (2023) A biomimetic mineralization nanosystem based on glycolysis-oxidative stress-autophagy regulation for the suppression of malignant tumor and lung metastasis. CHEMICAL ENGINEERING JOURNAL, 468 (143730). [PMID:]
3. Wang Shuqi, Zhou Li, Tian Hailong, Li Bowen, Su Miao, Li Qiong, Nice Edouard C., Huang Canhua, Shao Jichun, He Tao. (2023) Site-specific nanomodulator capable of modulation apoptosis for enhanced colorectal cancer chemo-photothermal therapy. JOURNAL OF NANOBIOTECHNOLOGY, 21 (1): (1-15). [PMID:36670444]

References

1. Si L et al.. (2021) A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.. Nat Biomed Eng, 5 (8): (815-829). [PMID:33941899]
2. Miyamoto M et al.. (2017) Inhibition of autophagy protein LC3A as a therapeutic target in ovarian clear cell carcinomas.. J Gynecol Oncol, 28 (3): (e33). [PMID:28382796]
3. Jiezhou Pan, Haotian Liao, Guidong Gong, Yunxiang He, Qin Wang, Lang Qin, Yaoyao Zhang, Hirotaka Ejima, Blaise L. Tardy, Joseph J. Richardson, Jiaojiao Shang, Orlando J. Rojas, Yong Zeng, Junling Guo. (2023) Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels. JOURNAL OF CONTROLLED RELEASE, 360 (433). [PMID:37422124]
4. Ping Guan, Zhaoxu Meng, Xinran Liu, Jiaxiang Mu, Zichun Gao, Xinrong Yu, He Lian. (2023) A biomimetic mineralization nanosystem based on glycolysis-oxidative stress-autophagy regulation for the suppression of malignant tumor and lung metastasis. CHEMICAL ENGINEERING JOURNAL, 468 (143730). [PMID:]
5. Wang Shuqi, Zhou Li, Tian Hailong, Li Bowen, Su Miao, Li Qiong, Nice Edouard C., Huang Canhua, Shao Jichun, He Tao. (2023) Site-specific nanomodulator capable of modulation apoptosis for enhanced colorectal cancer chemo-photothermal therapy. JOURNAL OF NANOBIOTECHNOLOGY, 21 (1): (1-15). [PMID:36670444]

Solution Calculators

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Hydroxychloroquine sulfate - ≥98%, high purity , Toll-like receptor 9 antagonist, CAS No.747-36-4, Toll-like receptor 9 antagonist

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

more

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator