Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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H106352-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $19.90 | |
H106352-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $75.90 | |
H106352-25g | 25g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $269.90 | |
H106352-100g | 100g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $659.90 | |
H106352-500g | 500g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,999.90 |
Ribonucleotide reductase inhibitor
Synonyms | SQ-1089 | NSC 32065 | Hidrix | Hidroxicarbamida | EINECS 204-821-7 | HU | NCGC00015520-03 | Carbamohydroximic acid | Hydroxyurea, 98%, powder | Hydroxycarbamide | Hydroxycarbamide [INN] | SMR000059149 | HYDROXYUREA [USAN] | urea, N-hydroxy- | Hydrea | Lit |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchroni |
Storage Temp | Store at 2-8°C,Argon charged |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Ribonucleoside-diphosphate reductase RR1 inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Hydroxyurea has been used: • for cell cycle synchronization in MCF-7 human breast carcinoma cells, Schizosaccharomyces pombe, primary root of seedling • as a drug for treating the parasite Leishmania mexicana in cell viability and cell cycle assay • as an inhibitor in the cell adhesion and motility assay in Caki control and CD9 knockdown cells |
ALogP | -1.8 |
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IUPAC Name | hydroxyurea |
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INCHI | InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4) |
InChi Key | VSNHCAURESNICA-UHFFFAOYSA-N |
Canonical SMILES | C(=O)(N)NO |
Isomeric SMILES | C(=O)(N)NO |
WGK Germany | 3 |
RTECS | YT4900000 |
PubChem CID | 3657 |
UN Number | 2811 |
Packing Group | I |
Molecular Weight | 76.05 |
Beilstein | 1741548 |
Reaxy-Rn | 1741548 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G2415153 | Certificate of Analysis | Apr 26, 2024 | H106352 |
G2415154 | Certificate of Analysis | Apr 26, 2024 | H106352 |
G2416607 | Certificate of Analysis | Apr 26, 2024 | H106352 |
A2402452 | Certificate of Analysis | Dec 18, 2023 | H106352 |
A2402454 | Certificate of Analysis | Dec 18, 2023 | H106352 |
A2402455 | Certificate of Analysis | Dec 18, 2023 | H106352 |
A2402456 | Certificate of Analysis | Dec 18, 2023 | H106352 |
H2229355 | Certificate of Analysis | Jun 18, 2022 | H106352 |
H2229381 | Certificate of Analysis | Jun 18, 2022 | H106352 |
H2229382 | Certificate of Analysis | Jun 18, 2022 | H106352 |
H2229386 | Certificate of Analysis | Jun 18, 2022 | H106352 |
F1822046 | Certificate of Analysis | Apr 26, 2022 | H106352 |
Solubility | Soluble in water, hot alcohol and dimethyl sulfoxide. Insoluble in ethanol and benzene |
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Sensitivity | Moisture sensitive |
Melt Point(°C) | 145°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H319:Causes serious eye irritation H412:Harmful to aquatic life with long lasting effects |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. |
WGK Germany | 3 |
RTECS | YT4900000 |
Reaxy-Rn | 1741548 |
Class | 6.1 |
Merck Index | 4848 |
Starting at $158.90
1. Kai Wang, Wentao Zhou, Xiangyu Jin, Xuwei Shang, Xiaomei Wu, Lijuan Wen, Sufen Li, Yiling Hong, Jia Ke, Yichong Xu, Hong Yuan, Fuqiang Hu. (2023) Enhanced brain delivery of hypoxia-sensitive liposomes by hydroxyurea for rescue therapy of hyperacute ischemic stroke. Nanoscale, 15 (27): (11625-11646). [PMID:37377137] |
1. Kai Wang, Wentao Zhou, Xiangyu Jin, Xuwei Shang, Xiaomei Wu, Lijuan Wen, Sufen Li, Yiling Hong, Jia Ke, Yichong Xu, Hong Yuan, Fuqiang Hu. (2023) Enhanced brain delivery of hypoxia-sensitive liposomes by hydroxyurea for rescue therapy of hyperacute ischemic stroke. Nanoscale, 15 (27): (11625-11646). [PMID:37377137] |