Hyperforin - 98%, high purity , CAS No.11079-53-1, Agonist of Pregnane X receptor;Activator of TRPC6

Item Number
H275963
Grouped product items
SKUSizeAvailabilityPrice Qty
H275963-1mg
1mg
In stock
$289.90
H275963-500μg
500μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$188.90
H275963-5mg
5mg
In stock
$1,303.90

'Description': "Key constituent of St. John's wort", 'Alternative names': ' Hyp-DCHA Hyperforin-DCHA

Basic Description

Synonyms(+)-Hyperforin | Q412742 | UNII-RM741E34FP | HYPERFORIN [HSDB] | Spectrum5_002025 | GTPL2764 | HYPERFORIN (CONSTITUENT OF ST. JOHN'S WORT) [DSC] | C07608 | HSDB 7646 | hyperforin | DB01892 | IWBJJCOKGLUQIZ-HQKKAZOISA-N | BICYCLO(3.3.1)NON-3-ENE-2,9-DIONE,
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological Mechanisms'Biological description': "Key constituent of St. John's wort. Various pharmacological effects. Antibacterial, antimalarial, anti-inflammatory, anticancer, antiangiogenic and antidepressant effects. Potential anti-Alzheimer compound. Active in vitro and i
Storage TempProtected from light,Store at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeACTIVATOR, AGONIST
Mechanism of actionAgonist of Pregnane X receptor;Activator of TRPC6
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.

Associated Targets(Human)

TRPC6 Tchem Short transient receptor potential channel 6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NR1I2 Tchem Nuclear receptor subfamily 1 group I member 2 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (1R,5R,7S,8R)-4-hydroxy-8-methyl-3,5,7-tris(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-1-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione
INCHI InChI=1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,37H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1
InChi Key KGSZHKRKHXOAMG-HQKKAZOISA-N
Canonical SMILES CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C
Isomeric SMILES CC(C)C(=O)[C@]12C(=O)C(=C([C@](C1=O)(C[C@@H]([C@@]2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C
WGK Germany 2
Alternate CAS 238074-03-8
PubChem CID 441298
Molecular Weight 536.78

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
F2229365Certificate of AnalysisApr 14, 2023 H275963
F2229366Certificate of AnalysisApr 14, 2023 H275963
F2229367Certificate of AnalysisApr 14, 2023 H275963

Chemical and Physical Properties

SolubilitySoluble in ethanol and in DMSO to 10 mM
Sensitivityair and light sensitive
Flash Point(°F)48.2 °F
Flash Point(°C)9 °C

Safety and Hazards(GHS)

Signal Danger
Hazard Statements

H225:Highly Flammable liquid and vapor

H370:Causes damage to organs

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378:In case of fire: Use ... to extinguish.

P210:Keep away from heat, hot surface, sparks, open flames and other ignition sources. - No smoking.

P403+P235:Store in a well-ventilated place. Keep cool.

WGK Germany 2
RIDADR UN1230-class3-PG2-Methanol

Related Documents

References

1. Tao R et al..  (2020)  Probing the therapeutic potential of TRPC6 for Alzheimer's disease in live neurons from patient-specific iPSCs..  J Mol Cell Biol,  12  (10): (807-816).  [PMID:32492143]

Solution Calculators