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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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H275963-1mg | 1mg | In stock | $289.90 | |
H275963-500μg | 500μg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $188.90 | |
H275963-5mg | 5mg | In stock | $1,303.90 |
'Description': "Key constituent of St. John's wort", 'Alternative names': ' Hyp-DCHA Hyperforin-DCHA
Synonyms | (+)-Hyperforin | Q412742 | UNII-RM741E34FP | HYPERFORIN [HSDB] | Spectrum5_002025 | GTPL2764 | HYPERFORIN (CONSTITUENT OF ST. JOHN'S WORT) [DSC] | C07608 | HSDB 7646 | hyperforin | DB01892 | IWBJJCOKGLUQIZ-HQKKAZOISA-N | BICYCLO(3.3.1)NON-3-ENE-2,9-DIONE, |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | 'Biological description': "Key constituent of St. John's wort. Various pharmacological effects. Antibacterial, antimalarial, anti-inflammatory, anticancer, antiangiogenic and antidepressant effects. Potential anti-Alzheimer compound. Active in vitro and i |
Storage Temp | Protected from light,Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ACTIVATOR, AGONIST |
Mechanism of action | Agonist of Pregnane X receptor;Activator of TRPC6 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | (1R,5R,7S,8R)-4-hydroxy-8-methyl-3,5,7-tris(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-1-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione |
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INCHI | InChI=1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,37H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1 |
InChi Key | KGSZHKRKHXOAMG-HQKKAZOISA-N |
Canonical SMILES | CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C |
Isomeric SMILES | CC(C)C(=O)[C@]12C(=O)C(=C([C@](C1=O)(C[C@@H]([C@@]2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C |
WGK Germany | 2 |
Alternate CAS | 238074-03-8 |
PubChem CID | 441298 |
Molecular Weight | 536.78 |
ChEBI | CHEBI:5834 |
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CAS Registry No. | 11079-53-1 |
Wikipedia | Hyperforin |
PubChem CID | 441298 |
NURSA Ligand | 10.1621/LQVF2FDO5A |
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Solubility | Soluble in ethanol and in DMSO to 10 mM |
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Sensitivity | air and light sensitive |
Flash Point(°F) | 48.2 °F |
Flash Point(°C) | 9 °C |
Signal | Danger |
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Hazard Statements | H225:Highly Flammable liquid and vapor H370:Causes damage to organs |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use ... to extinguish. P210:Keep away from heat, hot surface, sparks, open flames and other ignition sources. - No smoking. P403+P235:Store in a well-ventilated place. Keep cool. |
WGK Germany | 2 |
RIDADR | UN1230-class3-PG2-Methanol |
1. Tao R et al.. (2020) Probing the therapeutic potential of TRPC6 for Alzheimer's disease in live neurons from patient-specific iPSCs.. J Mol Cell Biol, 12 (10): (807-816). [PMID:32492143] |