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I-BET151 - ≥98%, high purity , CAS No.1300031-49-5, Inhibitor of bromodomain containing 2;Inhibitor of bromodomain containing 3;Inhibitor of bromodomain containing 4

Moligand™
≥98%

CAS#: 1300031-49-5
Formula: C₂₃H₂₁N₅O₃
Molecular Weight: 415.44
PubChem CID: 52912189

Item Number

I124882

Grouped product items
SKU	Size	Availability	Price
I124882-1mg	1mg	In stock	$28.90
I124882-5mg	5mg	In stock	$117.90
I124882-10mg	10mg	In stock	$141.90
I124882-50mg	50mg	In stock	$426.90
I124882-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$747.90

An isoxazole class pan-BET family inhibitor.

View related series

bromodomain containing 2 Inhibitor bromodomain containing 3 Inhibitor bromodomain containing 4 Inhibitor

Basic Description

Synonyms	1300031-49-5\|I-BET151\|GSK1210151A\|I-BET151 (GSK1210151A)\|7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one\|GSK1210151A (I-BET151)\|CHEMBL2017291\|(R)-7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1-(1-(pyrid
Specifications & Purity	≥98%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of bromodomain containing 2;Inhibitor of bromodomain containing 3;Inhibitor of bromodomain containing 4

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 30 Activities

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRDT Tchem Bromodomain testis-specific protein 1 Activities

Discover Target: BRDT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD3 Tchem Bromodomain-containing protein 3 9 Activities

Discover Target: BRD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD2 Tchem Bromodomain-containing protein 2 9 Activities

Discover Target: BRD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	7-(3,5-dimethyl-1,2-oxazol-4-yl)-8-methoxy-1-[(1R)-1-pyridin-2-ylethyl]-3H-imidazo[4,5-c]quinolin-2-one
INCHI	InChI=1S/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/m1/s1
InChi Key	VUVUVNZRUGEAHB-CYBMUJFWSA-N
Canonical SMILES	CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=O)N4)C(C)C5=CC=CC=N5)OC
Isomeric SMILES	CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=O)N4)[C@H](C)C5=CC=CC=N5)OC
WGK Germany	3
PubChem CID	52912189
Molecular Weight	415.44

ChEMBL Ligand

PubChem CID

CAS Registry No.

RCSB PDB Ligand

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
J2220287	Certificate of Analysis	Aug 15, 2024	I124882
J2220293	Certificate of Analysis	Aug 15, 2024	I124882
J2220299	Certificate of Analysis	Aug 15, 2024	I124882
J2220300	Certificate of Analysis	Aug 15, 2024	I124882
J2220303	Certificate of Analysis	Aug 15, 2024	I124882

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
WGK Germany	3

References

1. Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan WI, Robson SC, Chung CW, Hopf C, Savitski MM et al.. (2011) Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.. Nature, 478 (7370): (529-33). [PMID:21964340]
2. Bamborough P, Diallo H, Goodacre JD, Gordon L, Lewis A, Seal JT, Wilson DM, Woodrow MD, Chung CW. (2012) Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides.. J Med Chem, 55 (2): (587-96). [PMID:22136469]

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