I-BRD9 - ≥98%(HPLC), high purity , CAS No.1714146-59-4, Inhibitor of bromodomain containing 9

Item Number

I287753

Grouped product items
SKU	Size	Availability	Price
I287753-5mg	5mg	In stock	$97.90
I287753-10mg	10mg	In stock	$162.90
I287753-25mg	25mg	In stock	$347.90
I287753-50mg	50mg	In stock	$619.90
I287753-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,088.90

Potent and selective BRD9 inhibitor

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Basic Description

Synonyms	5-Ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide；N-(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)-5-ethyl-4-oxo-7-(3-(trifluoromethyl)phenyl)-4,5-dihydrothieno[3,2-c]pyr
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent and selective BRD9 inhibitor (pIC50= 7.3). Exhibits >70-fold selectivity for BRD9 over a panel of 34 other bromodomains and >700-fold selectivity over the BET family. DownregulatesCLEC1,DUSP6,FESandSAMSN1 genes in Kasumi-1 cells.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of bromodomain containing 9
Product Description	I-BRD9 is developed from thienopyridone scaffold. It can also be used as an identifier for BRD9 regulated gene in Kasumi-1 cells involved in oncology and immune response pathways.

Names and Identifiers

IUPAC Name	N'-(1,1-dioxothian-4-yl)-5-ethyl-4-oxo-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide
INCHI	InChI=1S/C22H22F3N3O3S2/c1-2-28-12-17(13-4-3-5-14(10-13)22(23,24)25)19-16(21(28)29)11-18(32-19)20(26)27-15-6-8-33(30,31)9-7-15/h3-5,10-12,15H,2,6-9H2,1H3,(H2,26,27)
InChi Key	WRUWGLUCNBMGPS-UHFFFAOYSA-N
Canonical SMILES	CCN1C=C(C2=C(C1=O)C=C(S2)C(=NC3CCS(=O)(=O)CC3)N)C4=CC(=CC=C4)C(F)(F)F
Isomeric SMILES	CCN1C=C(C2=C(C1=O)C=C(S2)C(=NC3CCS(=O)(=O)CC3)N)C4=CC(=CC=C4)C(F)(F)F
PubChem CID	91668541
Molecular Weight	497.55

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
F2229382	Certificate of Analysis	Jun 04, 2022	I287753
F2229383	Certificate of Analysis	Jun 04, 2022	I287753
F2229447	Certificate of Analysis	Jun 04, 2022	I287753
F2229448	Certificate of Analysis	Jun 04, 2022	I287753
F2229449	Certificate of Analysis	Jun 04, 2022	I287753

Pictogram(s)

Signal

Warning

Hazard Statements

H301:Toxic if swallowed

Precautionary Statements

P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/...

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Basic Description