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I-CBP112 , CAS No.I610918, Inhibitor of CREB binding protein;Inhibitor of E1A binding protein p300
Basic Description Specifications & Purity Moligand™ Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of CREB binding protein;Inhibitor of E1A binding protein p300
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens
Names and Identifiers IUPAC Name 1-[7-(3,4-dimethoxyphenyl)-9-{[(3S)-1-methylpiperidin-3-yl]methoxy}-2,3,4,5-tetrahydro-1,4-benzoxazepin-4-yl]propan-1-one INCHI InChI=1S/C27H36N2O5/c1-5-26(30)29-11-12-33-27-22(17-29)13-21(20-8-9-23(31-3)24(14-20)32-4)15-25(27)34-18-19-7-6-10-28(2)16-19/h8-9,13-15,19H,5-7,10-12,16-18H2,1-4H3/t19-/m0/s1 InChi Key YKNAKDFZAWQEEO-IBGZPJMESA-N Canonical SMILES CCC(=O)N1CCOc2c(C1)cc(cc2OC[C@H]1CCCN(C1)C)c1ccc(c(c1)OC)OC Isomeric SMILES CCC(=O)N1CCOC2=C(C1)C=C(C=C2OC[C@H]3CCCN(C3)C)C4=CC(=C(C=C4)OC)OC PubChem CID 90488984
References 1. Zeng L, Zhang Q, Gerona-Navarro G, Moshkina N, Zhou MM. (2008) Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300.. Structure, 16 (4): (643-52). [PMID:18400184 ] [10.1021/op500134e ] 2. Iyer NG, Ozdag H, Caldas C. (2004) p300/CBP and cancer.. Oncogene, 23 (24): (4225-31). [PMID:15156177 ] [10.1021/op500134e ] 3. Kalkhoven E. (2004) CBP and p300: HATs for different occasions.. Biochem Pharmacol, 68 (6): (1145-55). [PMID:15313412 ] [10.1021/op500134e ]
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