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Ibudilast - 99%, high purity , Phosphodiesterase 5A inhibitor, CAS No.50847-11-5, Phosphodiesterase 5A inhibitor

Moligand™
≥99%

CAS#: 50847-11-5
Formula: C₁₄H₁₈N₂O
Molecular Weight: 230.31
Beilstein Registry Number: 24(5)3,396
MDL number: MFCD00864808
PubChem CID: 3671

Item Number

I121706

Grouped product items
SKU	Size	Availability	Price
I121706-25mg	25mg	In stock	$29.90
I121706-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$98.90
I121706-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$222.90
I121706-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$801.90
I121706-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,608.90

Non-selective PDE inhibitor. Anti-inflammatory agent.

View related series

Allosteric modulator phosphodiesterase 3A Inhibitor phosphodiesterase 4A Inhibitor phosphodiesterase 4B Inhibitor phosphodiesterase 4C Inhibitor phosphodiesterase 5A Inhibitor

Basic Description

Synonyms	ibudilast\|50847-11-5\|Ketas\|KC-404\|MN-166\|Ibudilastum\|Ke Tas\|Ibudilastum [Latin]\|AV-411\|Ibudilast [INN:JAN]\|Eyevinal\|Ketas (TN)\|1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one\|2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-on
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.Non-selective PDE inhibitor (IC 50 values are 53, 35, 48, 12 and 10 μM for PDE Ia, II, III, IV and V respectively). Anti-inflammatory agent. Inhibits platelet aggregatio
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Phosphodiesterase 5A inhibitor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Names and Identifiers

IUPAC Name	2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
INCHI	InChI=1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3
InChi Key	ZJVFLBOZORBYFE-UHFFFAOYSA-N
Canonical SMILES	CC(C)C1=NN2C=CC=CC2=C1C(=O)C(C)C
Isomeric SMILES	CC(C)C1=NN2C=CC=CC2=C1C(=O)C(C)C
WGK Germany	3
RTECS	UR0711200
PubChem CID	3671
Molecular Weight	230.31
Beilstein	24(5)3,396
Reaxy-Rn	656579

ChEMBL Ligand

DrugBank Ligand

Wikipedia

CAS Registry No.

PubChem CID

RCSB PDB Ligand

DrugCentral Ligand

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

9 results found

Lot Number	Certificate Type	Date	Item
A2415430	Certificate of Analysis	Nov 22, 2023	I121706
A2415431	Certificate of Analysis	Nov 22, 2023	I121706
A2415432	Certificate of Analysis	Nov 22, 2023	I121706
A2415433	Certificate of Analysis	Nov 22, 2023	I121706
A2415434	Certificate of Analysis	Nov 22, 2023	I121706
A2415435	Certificate of Analysis	Nov 22, 2023	I121706
K1821148	Certificate of Analysis	Sep 19, 2022	I121706
K1821147	Certificate of Analysis	Sep 19, 2022	I121706
I1417017	Certificate of Analysis	Jul 11, 2022	I121706

Sensitivity

Heat Sensitive

Boil Point(°C)

175°C/7.5mmHg

Melt Point(°C)

56°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	UR0711200
Reaxy-Rn	656579
Merck Index	4879

References

1. Cho Y, Crichlow GV, Vermeire JJ, Leng L, Du X, Hodsdon ME, Bucala R, Cappello M, Gross M, Gaeta F et al.. (2010) Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.. Proc Natl Acad Sci USA, 107 (25): (11313-8). [PMID:20534506]
2. Fox RJ, Coffey CS, Conwit R, Cudkowicz ME, Gleason T, Goodman A, Klawiter EC, Matsuda K, McGovern M, Naismith RT et al.. (2018) Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis.. N Engl J Med, 379 (9): (846-855). [PMID:30157388]
3. Kodimuthali A, Jabaris SS, Pal M. (2008) Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.. J Med Chem, 51 (18): (5471-89). [PMID:18686943]

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Ibudilast - 99%, high purity , Phosphodiesterase 5A inhibitor, CAS No.50847-11-5, Phosphodiesterase 5A inhibitor

Basic Description

Product Properties

Names and Identifiers

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