Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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I275786-5mg | 5mg | In stock | $78.90 | |
I275786-25mg | 25mg | In stock | $226.90 | |
I275786-100mg | 100mg | In stock | $817.90 | |
I275786-250mg | 250mg | In stock | $1,838.90 | |
I275786-500mg | 500mg | In stock | $3,309.90 |
Selective CK1δ and CK1ε inhibitor. Potent microtubulin polymerization inhibitor.
Synonyms | ic261 | 186611-52-9 | IC 261 | SU-5607 | 3-[(2,4,6-TRIMETHOXY-PHENYL)-METHYLENE]-INDOLIN-2-ONE | (3E)-3-[(2,4,6-trimethoxyphenyl)methylidene]-1H-indol-2-one | 3-[(2,4,6-Trimethoxyphenyl)methylidenyl]-indolin-2-one | CHEMBL489156 | (E)-3-(2,4,6-trimethoxybenzylidene)indol |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Selective CK1δ and CK1ε inhibitor. Potent microtubulin polymerization inhibitor. Induces cell cycle arrest and apoptosis. Selectively inhibits tumor cells growth. Shows antitumor effects in vivo. |
Source | Synthetic |
Storage Temp | Protected from light,Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of casein kinase 1 alpha 1;Inhibitor of casein kinase 1 delta;Inhibitor of casein kinase 1 epsilon |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. |
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IUPAC Name | (3E)-3-[(2,4,6-trimethoxyphenyl)methylidene]-1H-indol-2-one |
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INCHI | InChI=1S/C18H17NO4/c1-21-11-8-16(22-2)14(17(9-11)23-3)10-13-12-6-4-5-7-15(12)19-18(13)20/h4-10H,1-3H3,(H,19,20)/b13-10+ |
InChi Key | JBJYTZXCZDNOJW-JLHYYAGUSA-N |
Canonical SMILES | COC1=CC(=C(C(=C1)OC)C=C2C3=CC=CC=C3NC2=O)OC |
Isomeric SMILES | COC1=CC(=C(C(=C1)OC)/C=C/2\C3=CC=CC=C3NC2=O)OC |
PubChem CID | 5288600 |
Molecular Weight | 311.34 |
PubChem CID | 3674 |
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ChEMBL Ligand | CHEMBL576349 |
CAS Registry No. | 186611-52-9 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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K2203421 | Certificate of Analysis | Aug 04, 2023 | I275786 |
K2203437 | Certificate of Analysis | Aug 04, 2023 | I275786 |
K2203438 | Certificate of Analysis | Aug 04, 2023 | I275786 |
K2203453 | Certificate of Analysis | Aug 04, 2023 | I275786 |
K2203475 | Certificate of Analysis | Aug 04, 2023 | I275786 |
Solubility | Soluble in DMSO to 50 mM |
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Sensitivity | light sensitive |
Melt Point(°C) | 214 °C |
1. Tsukiyama T et al.. (2020) A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.. Nat Commun, 11 (4586). [PMID:32934222] |